PDB ID: 3PPM
Hetero Atom Contents
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Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
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1DO | 1-dodecanol | PoSSuM | |||
CL | Chloride ion | PoSSuM | |||
F | Fluoride ion | PoSSuM | |||
JG1 | 7-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]heptan-1-one | PoSSuM | |||
PEG | Di(hydroxyethyl)ether | PoSSuM |
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Download interaction data: 3PPM
Structure summary
Code : | 3PPM PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Crystal Structure of a Noncovalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase | ||||||||||||
Release Data : | 2011-11-09 | ||||||||||||
Compound : |
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Authors : | Mileni, M., Han, G.W., Boger, D.L., Stevens, R.C. | ||||||||||||
Keywords : | protein-inhibitor complex, FAAH, oxazole, oxadiazole, endocannabinoid degradation, membrane protein, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.780 Å ) | ||||||||||||
Citation : |
Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase.
Mileni, M.,Garfunkle, J.,Ezzili, C.
et al.
PubMed: 21355555 |
Reaction
Chain : | A, B | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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UniProt : | P97612 (FAAH1_RAT) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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