PDB ID: 3H59
Hetero Atom Contents
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|Title :||hepatitis C virus polymerase ns5b with thiazine inhibitor 2|
|Release Data :||2009-09-08|
|Authors :||S.F.Harris, M.Ghate|
|Keywords :||hcv, hepatitis, ns5b, transferase rna-dependent rna polymerase, acetylation, apoptosis, atp-binding, capsid protein, cell membrane, cytoplasm, disulfide bond, endoplasmic reticulum, envelope protein, fusion protein, glycoprotein, helicase, host-virus interaction, hydrolase, interferon antiviral system evasion, lipid droplet, lipoprotein, membrane, metal-binding, mitochondrion, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, oncogene, palmitate, phosphoprotein, protease, ribonucleoprotein, rna replication, rna-binding, rna-directed rna polymerase, secreted, serine protease, sh3-binding, thiol protease, transcription, transcription regulation, transferase, transmembrane, ubl conjugation, viral nucleoprotein, virion, zinc|
|Exp. method :||X-ray diffraction ( 2.1 Å )|
|Chain :||A, B|
|UniProt :||P26663 (POLG_HCVBK)|
|Reaction :||Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
NTP + H(2)O = NDP + phosphate.
ATP + H(2)O = ADP + phosphate.