PDB ID: 3H59
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H59 | N-{3-[(5s)-5-(1,1-dimethylpropyl)-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1h-pyrrol-3-yl]-1,1-dioxido-4h-1,4-benzothiazin-7-yl}methanesulfonamide | PoSSuM |
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Download interaction data: 3H59
Structure summary
Code : | 3H59 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Hepatitis C virus polymerase NS5B with thiazine inhibitor 2 | ||||||||||||
Release Data : | 2009-09-08 | ||||||||||||
Compound : |
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Authors : | Harris, S.F., Ghate, M. | ||||||||||||
Keywords : | HCV, HEPATITIS, NS5B, TRANSFERASE RNA-DEPENDENT RNA POLYMERASE, Acetylation, Apoptosis, ATP-binding, Capsid protein, Cell membrane, Cytoplasm, Disulfide bond, Endoplasmic reticulum, Envelope protein, Fusion protein, Glycoprotein, Helicase, Host-virus interaction, Hydrolase, Interferon antiviral system evasion, Lipid droplet, Lipoprotein, Membrane, Metal-binding, Mitochondrion, Multifunctional enzyme, Nucleotide-binding, Nucleotidyltransferase, Nucleus, Oncogene, Palmitate, Phosphoprotein, Protease, Ribonucleoprotein, RNA replication, RNA-binding, RNA-directed RNA polymerase, Secreted, Serine protease, SH3-binding, Thiol protease, Transcription, Transcription regulation, Transferase, Transmembrane, Ubl conjugation, Viral nucleoprotein, Virion, Zinc | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.10 Å ) | ||||||||||||
Citation : |
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids
de Vicente, J.,Hendricks, R.T.,Smith, D.B.
et al.
PubMed: 19700319 |
Reaction
Chain : | A, B | ||||||||||||||||||||
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UniProt : | P26663 (POLG_HCVBK) | ||||||||||||||||||||
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