Brand  (β version)

color scheme of protein:

hetatm:

chain: Hide other chain(s)

Code Name Link
H59 N-{3-[(5s)-5-(1,1-dimethylpropyl)-1-(4-fluoro-3- methylbenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1h-pyrrol-3- yl]-1,1-dioxido-4h-1,4-benzothiazin-7- yl}methanesulfonamide
Code : 3H59
Header : transferase
Title : hepatitis C virus polymerase ns5b with thiazine inhibitor 2
Release Data : 2009-09-08
Compound :
mol_id 1
molecule rna-directed rna polymerase
chain A, B
fragment sequence database residues 2421-2989
synonym ns5b, p68
ec 2.7.7.48
engineered yes
Source :
mol_id 1
organism_scientific Hepatitis c virus
organism_taxid 11105
strain bk
gene ns5b
expression_system Escherichia coli
expression_system_taxid 562
Authors : S.F.Harris, M.Ghate
Keywords : hcv, hepatitis, ns5b, transferase rna-dependent rna polymerase, acetylation, apoptosis, atp-binding, capsid protein, cell membrane, cytoplasm, disulfide bond, endoplasmic reticulum, envelope protein, fusion protein, glycoprotein, helicase, host-virus interaction, hydrolase, interferon antiviral system evasion, lipid droplet, lipoprotein, membrane, metal-binding, mitochondrion, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, oncogene, palmitate, phosphoprotein, protease, ribonucleoprotein, rna replication, rna-binding, rna-directed rna polymerase, secreted, serine protease, sh3-binding, thiol protease, transcription, transcription regulation, transferase, transmembrane, ubl conjugation, viral nucleoprotein, virion, zinc
Exp. method : X-ray diffraction ( 2.1 Å )
Chain : A, B
UniProt : P26663 (POLG_HCVBK)
Reaction : Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
NTP + H(2)O = NDP + phosphate.
ATP + H(2)O = ADP + phosphate.