ID 3H59A STANDARD; PRT; 576 AA. DT CONVERTED FROM PDB (SEQRES) 3H59 DE RNA-directed RNA polymerase OS Hepatitis C virus CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.100 CC R-Factor 0.195 FT #SUB 79 73 ALA A 441 435 ALA B Protein S 1 FT #SUB 79 73 ALA A 442 436 GLN B Protein A 7 FT #SUB 80 74 LYS A 442 436 GLN B Protein A 3 FT #SUB 82 76 SER A 31 25 ALA B Protein B 1 FT #SUB 82 76 SER A 442 436 GLN B Protein S 1 FT #SUB 83 77 THR A 30 24 ASN B Protein B 6 FT #SUB 83 77 THR A 31 25 ALA B Protein B 6 FT #SUB 83 77 THR A 32 26 LEU B Protein S 1 FT #SUB 83 77 THR A 442 436 GLN B Protein S 1 FT #SUB 84 78 VAL A 31 25 ALA B Protein B 3 FT #SUB 85 79 LYS A 30 24 ASN B Protein S 1 FT #SUB 85 79 LYS A 31 25 ALA B Protein A 3 FT #SUB 215 209 LYS A 113 107 ASP B Protein S 6 FT #SUB 250 244 ASP A 31 25 ALA B Protein S 1 FT #SUB 385 379 LYS A 106 100 LYS B Protein S 4 FT #SUB 544 538 PRO A 276 270 LYS B Protein S 2 FT #SUB 544 538 PRO A 278 272 GLN B Protein S 5 FT #SUB 549 543 SER A 276 270 LYS B Protein S 1 FT #HET 199 193 PHE A 1 571 H59 A S 4 FT #HET 203 197 PRO A 1 571 H59 A A 4 FT #HET 206 200 ARG A 1 571 H59 A S 4 FT #HET 294 288 SER A 1 571 H59 A A 3 FT #HET 297 291 ASN A 1 571 H59 A S 4 FT #HET 322 316 ASN A 1 571 H59 A B 3 FT #HET 323 317 GLY A 1 571 H59 A B 2 FT #HET 324 318 ASP A 1 571 H59 A A 10 FT #HET 372 366 CYS A 1 571 H59 A A 6 FT #HET 374 368 SER A 1 571 H59 A S 1 FT #HET 390 384 LEU A 1 571 H59 A S 1 FT #HET 416 410 GLY A 1 571 H59 A B 3 FT #HET 417 411 ASN A 1 571 H59 A S 1 FT #HET 420 414 MET A 1 571 H59 A A 6 FT #HET 421 415 TYR A 1 571 H59 A S 6 FT #HET 452 446 GLN A 1 571 H59 A B 2 FT #HET 453 447 ILE A 1 571 H59 A B 2 FT #HET 454 448 TYR A 1 571 H59 A A 16 FT #HET 455 449 GLY A 1 571 H59 A B 6 FT #HET 562 556 SER A 1 571 H59 A S 5 FT DISORDER 1 6 FT DISORDER 155 159 FT DISORDER 569 576 CC SEQUENCE 557 AA (ATOM); CC HMSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSAGLRQK KVTFDRLQVL CC DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK FGYGAKDVRN LSSKAVNHIH CC SVWKDLLEDT VTPIDTTIMA KNEVFCVQRK PARLIVFPDL GVRVCEKMAL YDVVSTLPQV CC VMGSSYGFQY SPGQRVEFLV NTWKSKKNPM GFSYDTRCFD STVTENDIRV EESIYQCCDL CC APEARQAIKS LTERLYIGGP LTNSKGQNCG YRRCRASGVL TTSCGNTLTC YLKASAACRA CC AKLQDCTMLV NGDDLVVICE SAGTQEDAAS LRVFTEAMTR YSAPPGDPPQ PEYDLELITS CC CSSNVSVAHD ASGKRVYYLT RDPTTPLARA AWETARHTPV NSWLGNIIMY APTLWARMIL CC MTHFFSILLA QEQLEKALDC QIYGACYSIE PLDLPQIIER LHGLSAFSLH SYSPGEINRV CC ASCLRKLGVP PLRVWRHRAR SVRARLLSQG GRAATCGKYL FNWAVKTKLK LTPIPAASRL CC DLSGWFVAGY SGGDIYH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MHHHHHHMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS CC ATOM ------HMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS CC ******************************************** CC SEQRES AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP CC ATOM AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP CC ************************************************** CC SEQRES HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV CC ATOM HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV CC ************************************************** CC SEQRES FCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ CC ATOM FCVQ-----RKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ CC **** ***************************************** CC SEQRES YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD CC ATOM YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD CC ************************************************** CC SEQRES LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT CC ATOM LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT CC ************************************************** CC SEQRES CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMT CC ATOM CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMT CC ************************************************** CC SEQRES RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR CC ATOM RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR CC ************************************************** CC SEQRES AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CC ATOM AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CC ************************************************** CC SEQRES CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV CC ATOM CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV CC ************************************************** CC SEQRES PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASR CC ATOM PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASR CC ************************************************** CC SEQRES LDLSGWFVAGYSGGDIYHSLSRARPR CC ATOM LDLSGWFVAGYSGGDIYH-------- CC ****************** SQ SEQUENCE 576 AA; MW; CN; MHHHHHHMSY TWTGALITPC AAEESKLPIN ALSNSLLRHH NMVYATTSRS AGLRQKKVTF DRLQVLDDHY RDVLKEMKAK ASTVKAKLLS VEEACKLTPP HSAKSKFGYG AKDVRNLSSK AVNHIHSVWK DLLEDTVTPI DTTIMAKNEV FCVQPEKGGR KPARLIVFPD LGVRVCEKMA LYDVVSTLPQ VVMGSSYGFQ YSPGQRVEFL VNTWKSKKNP MGFSYDTRCF DSTVTENDIR VEESIYQCCD LAPEARQAIK SLTERLYIGG PLTNSKGQNC GYRRCRASGV LTTSCGNTLT CYLKASAACR AAKLQDCTML VNGDDLVVIC ESAGTQEDAA SLRVFTEAMT RYSAPPGDPP QPEYDLELIT SCSSNVSVAH DASGKRVYYL TRDPTTPLAR AAWETARHTP VNSWLGNIIM YAPTLWARMI LMTHFFSILL AQEQLEKALD CQIYGACYSI EPLDLPQIIE RLHGLSAFSL HSYSPGEINR VASCLRKLGV PPLRVWRHRA RSVRARLLSQ GGRAATCGKY LFNWAVKTKL KLTPIPAASR LDLSGWFVAG YSGGDIYHSL SRARPR // ID 3H59B STANDARD; PRT; 576 AA. DT CONVERTED FROM PDB (SEQRES) 3H59 DE RNA-directed RNA polymerase OS Hepatitis C virus CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.100 CC R-Factor 0.195 FT #SUB 30 24 ASN B 83 77 THR A Protein A 6 FT #SUB 30 24 ASN B 85 79 LYS A Protein B 1 FT #SUB 31 25 ALA B 82 76 SER A Protein S 1 FT #SUB 31 25 ALA B 83 77 THR A Protein A 6 FT #SUB 31 25 ALA B 84 78 VAL A Protein S 3 FT #SUB 31 25 ALA B 85 79 LYS A Protein B 3 FT #SUB 31 25 ALA B 250 244 ASP A Protein S 1 FT #SUB 32 26 LEU B 83 77 THR A Protein S 1 FT #SUB 106 100 LYS B 385 379 LYS A Protein B 4 FT #SUB 113 107 ASP B 215 209 LYS A Protein S 6 FT #SUB 276 270 LYS B 544 538 PRO A Protein A 2 FT #SUB 276 270 LYS B 549 543 SER A Protein S 1 FT #SUB 278 272 GLN B 544 538 PRO A Protein S 5 FT #SUB 441 435 ALA B 79 73 ALA A Protein B 1 FT #SUB 442 436 GLN B 79 73 ALA A Protein S 7 FT #SUB 442 436 GLN B 80 74 LYS A Protein S 3 FT #SUB 442 436 GLN B 82 76 SER A Protein S 1 FT #SUB 442 436 GLN B 83 77 THR A Protein S 1 FT #HET 199 193 PHE B 2 571 H59 B S 4 FT #HET 203 197 PRO B 2 571 H59 B A 5 FT #HET 206 200 ARG B 2 571 H59 B S 4 FT #HET 294 288 SER B 2 571 H59 B A 3 FT #HET 297 291 ASN B 2 571 H59 B S 4 FT #HET 322 316 ASN B 2 571 H59 B B 4 FT #HET 323 317 GLY B 2 571 H59 B B 3 FT #HET 324 318 ASP B 2 571 H59 B A 9 FT #HET 372 366 CYS B 2 571 H59 B A 7 FT #HET 374 368 SER B 2 571 H59 B S 3 FT #HET 390 384 LEU B 2 571 H59 B S 2 FT #HET 416 410 GLY B 2 571 H59 B B 3 FT #HET 417 411 ASN B 2 571 H59 B S 1 FT #HET 420 414 MET B 2 571 H59 B A 3 FT #HET 421 415 TYR B 2 571 H59 B S 4 FT #HET 452 446 GLN B 2 571 H59 B B 2 FT #HET 453 447 ILE B 2 571 H59 B B 2 FT #HET 454 448 TYR B 2 571 H59 B A 14 FT #HET 455 449 GLY B 2 571 H59 B B 6 FT #HET 562 556 SER B 2 571 H59 B S 5 FT DISORDER 1 6 FT DISORDER 155 159 FT DISORDER 569 576 CC SEQUENCE 557 AA (ATOM); CC HMSYTWTGAL ITPCAAEESK LPINALSNSL LRHHNMVYAT TSRSAGLRQK KVTFDRLQVL CC DDHYRDVLKE MKAKASTVKA KLLSVEEACK LTPPHSAKSK FGYGAKDVRN LSSKAVNHIH CC SVWKDLLEDT VTPIDTTIMA KNEVFCVQRK PARLIVFPDL GVRVCEKMAL YDVVSTLPQV CC VMGSSYGFQY SPGQRVEFLV NTWKSKKNPM GFSYDTRCFD STVTENDIRV EESIYQCCDL CC APEARQAIKS LTERLYIGGP LTNSKGQNCG YRRCRASGVL TTSCGNTLTC YLKASAACRA CC AKLQDCTMLV NGDDLVVICE SAGTQEDAAS LRVFTEAMTR YSAPPGDPPQ PEYDLELITS CC CSSNVSVAHD ASGKRVYYLT RDPTTPLARA AWETARHTPV NSWLGNIIMY APTLWARMIL CC MTHFFSILLA QEQLEKALDC QIYGACYSIE PLDLPQIIER LHGLSAFSLH SYSPGEINRV CC ASCLRKLGVP PLRVWRHRAR SVRARLLSQG GRAATCGKYL FNWAVKTKLK LTPIPAASRL CC DLSGWFVAGY SGGDIYH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MHHHHHHMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS CC ATOM ------HMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRS CC ******************************************** CC SEQRES AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP CC ATOM AGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPP CC ************************************************** CC SEQRES HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV CC ATOM HSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEV CC ************************************************** CC SEQRES FCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ CC ATOM FCVQ-----RKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ CC **** ***************************************** CC SEQRES YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD CC ATOM YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD CC ************************************************** CC SEQRES LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT CC ATOM LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLT CC ************************************************** CC SEQRES CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMT CC ATOM CYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMT CC ************************************************** CC SEQRES RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR CC ATOM RYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLAR CC ************************************************** CC SEQRES AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CC ATOM AAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CC ************************************************** CC SEQRES CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV CC ATOM CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGV CC ************************************************** CC SEQRES PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASR CC ATOM PPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASR CC ************************************************** CC SEQRES LDLSGWFVAGYSGGDIYHSLSRARPR CC ATOM LDLSGWFVAGYSGGDIYH-------- CC ****************** SQ SEQUENCE 576 AA; MW; CN; MHHHHHHMSY TWTGALITPC AAEESKLPIN ALSNSLLRHH NMVYATTSRS AGLRQKKVTF DRLQVLDDHY RDVLKEMKAK ASTVKAKLLS VEEACKLTPP HSAKSKFGYG AKDVRNLSSK AVNHIHSVWK DLLEDTVTPI DTTIMAKNEV FCVQPEKGGR KPARLIVFPD LGVRVCEKMA LYDVVSTLPQ VVMGSSYGFQ YSPGQRVEFL VNTWKSKKNP MGFSYDTRCF DSTVTENDIR VEESIYQCCD LAPEARQAIK SLTERLYIGG PLTNSKGQNC GYRRCRASGV LTTSCGNTLT CYLKASAACR AAKLQDCTML VNGDDLVVIC ESAGTQEDAA SLRVFTEAMT RYSAPPGDPP QPEYDLELIT SCSSNVSVAH DASGKRVYYL TRDPTTPLAR AAWETARHTP VNSWLGNIIM YAPTLWARMI LMTHFFSILL AQEQLEKALD CQIYGACYSI EPLDLPQIIE RLHGLSAFSL HSYSPGEINR VASCLRKLGV PPLRVWRHRA RSVRARLLSQ GGRAATCGKY LFNWAVKTKL KLTPIPAASR LDLSGWFVAG YSGGDIYHSL SRARPR //