Brand  (β version)

PDB ID: 3ZOS

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Ligands
Code Name Style Show Link
0LI 3-(imidazo[1,2-B]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide PoSSuM
EDO 1,2-ethanediol PoSSuM
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Structure summary

Code : 3ZOS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of the DDR1 kinase domain in complex with ponatinib
Release Data : 2013-05-01
Compound :
mol_id molecule chains synonym
1 EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 A,B EPITHELIAL DISCOIDIN DOMAIN RECEPTOR, CD167 ANTIGEN-LIKE FAMILY MEMBER A, CELL ADHESION KINASE, DISCOIDIN RECEPTOR TYROSINE KINASE, HGK2, MAMMARY CARCINOMA KINASE 10, MCK-10, PROTEIN-TYROSINE KINASE 3A, PROTEIN-TYROSINE KINASE RTK-6, TRK E, TYROSINE KINASE DDR, TYROSINE-PROTEIN KINASE CAK, CD167A
ec: 2.7.10.1
fragment: KINASE DOMAIN, RESIDUES 601-913
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PFB-LIC-BSE
other_details: MAMMALIAN GENE COLLECTION (MGC)
Authors : Canning, P., Elkins, J.M., Goubin, S., Mahajan, P., Bradley, A., Coutandin, D., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Keywords : TRANSFERASE, RTK, COLLAGEN, DISCOIDIN DOMAIN
Exp. method : X-RAY DIFFRACTION ( 1.92 Å )
Citation :

Structural Mechanisms Determining Inhibition of the Collagen Receptor Ddr1 by Selective and Multi-Targeted Type II Kinase Inhibitors

Canning, P.,Elkins, J.M.,Goubin, S.  et al.
(2014)  J.Mol.Biol.  426 : 2457

PubMed: 24768818
DOI: 10.1016/J.JMB.2014.04.014

Reaction

Chain : A, B
UniProt : Q08345 (DDR1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028
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