Brand  (β version)

PDB ID: 3ZFR

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Ligands
Code Name Style Show Link
IR3 Iridium (III) ion PoSSuM
OH Hydroxide ion PoSSuM
SGM Monothioglycerol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3ZFR   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of product-like, processed N-terminal protease Npro with iridium
Release Data : 2013-05-15
Compound :
mol_id molecule chains synonym
1 N-TERMINAL PROTEASE NPRO A NONSTRUCTURAL PROTEIN
ec: 3.4.22.-
fragment: NPRO, RESIDUES 22-168
mutation: YES
Source :
mol_id organism_scientific expression_system
1 PESTIVIRUS STRAIN D32/00_HOBI  (taxid:266829) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PET30B
Authors : Zogg, T., Sponring, M., Schindler, S., Koll, M., Schneider, R., Brandstetter, H., Auer, B.
Keywords : HYDROLASE, AUTO-PROCESSING CYSTEINE PROTEASE, VIRAL PROTEASE, IN CIS- CLEAVAGE, HYDROXIDE-DEPENDENT CATALYSIS, AUTO-PROTEOLYSIS, IMMUNE MODULATION, HOST-PATHOGEN INTERACTION, CONVERGENT EVOLUTION
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis

Zogg, T.,Sponring, M.,Schindler, S.  et al.
(2013)  Structure  21 : 929

PubMed: 23643950
DOI: 10.1016/J.STR.2013.04.003

Reaction

Chain : A
UniProt : Q5L4B1 (Q5L4B1_9FLAV)
Reaction : -