PDB ID: 3UM5
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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CP6 | 5-(4-chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine | PoSSuM | |||
NDP | Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate | PoSSuM | |||
UMP | 2'-deoxyuridine 5'-monophosphate | PoSSuM |
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Download interaction data: 3UM5
Structure summary
Code : | 3UM5 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE, TRANSFERASE/INHIBITOR | ||||||||||||
Title : | Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP | ||||||||||||
Release Data : | 2012-07-18 | ||||||||||||
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Authors : | Vanichtanankul, J., Kamchonwongpaisan, S., Chitnumsub, P., Yuthavong, Y. | ||||||||||||
Keywords : | MALARIAL DHFR-TS, PYRIMETHAMINE, ANTIFOLATE, NAPDH, DUMP, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.40 Å ) | ||||||||||||
Citation : |
Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil.
Vanichtanankul, J.,Taweechai, S.,Uttamapinant, C.
et al.
PubMed: 22526319 |
Reaction
Chain : | A, B | ||||||||||||
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UniProt : | A7UD81 (A7UD81_PLAFA) | ||||||||||||
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