Het-PDB Navi2 (PDB: 3TJC)

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Ligands
Code	Name		Style	Show	Link
0TP	4-amino-N-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-C]pyridine-7-carboxamide				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
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Download interaction data: 3TJC

Code :

3TJC PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Co-crystal structure of jak2 with thienopyridine 8

Release Data :

2011-11-30

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK2	A,B	Janus kinase 2, JAK-2
	ec: 2.7.10.2 fragment: UNP residues 837-1132

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: JAK2

Authors :

Huang, X.

Keywords :

jak2, kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors.

Schenkel, L.B.,Huang, X.,Cheng, A. et al.
(2011) J.Med.Chem. 54 : 8440 - 8450

Chain :

A, B

UniProt :

O60674 (JAK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:15690087, PubMed:16174768, PubMed:7615558, PubMed:9618263
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000305	Mn(2+) was used in the in vitro kinase assay but Mg(2+) is likely to be the in vivo cofactor.

PDB ID: 3TJC