Brand  (β version)

PDB ID: 3QG2

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Ligands
Code Name Style Show Link
CP6 5-(4-chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
UMP 2'-deoxyuridine 5'-monophosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 3QG2   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE, TRANSFERASE/INHIBITOR
Title : Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex
Release Data : 2011-06-29
Compound :
mol_id molecule chains
1 Bifunctional dihydrofolate reductase-thymidylate synthase A,B
ec: 1.5.1.3, 2.1.1.45
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum  (taxid:5833) Escherichia coli  (taxid:562)
strain: V1/S
gene: DHFR-TS
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET17b
Authors : Vanichtanankul, J., Yuvaniyama, J., Taweechai, S., Chitnumsub, P., Kamchonwongpaisan, S., Yuthavong, Y.
Keywords : pyrimethamine, antifolate resistance, Plasmodium falciparum, dihydrofolate reductase, OXIDOREDUCTASE, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.3000 Å )
Citation :

Trypanosomal dihydrofolate reductase reveals natural antifolate resistance

Vanichtanankul, J.,Taweechai, S.,Yuvaniyama, J.  et al.
(2011)  Acs Chem.Biol.  6 : 905 - 911

PubMed: 21650210
DOI: 10.1021/cb200124r

Reaction

Chain : A, B
UniProt : D9N170 (D9N170_PLAFA)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+) 1.5.1.3 ARBA:ARBA00048873
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dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8- dihydrofolate + dTMP 2.1.1.45 ARBA:ARBA00047344
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