Het-PDB Navi2 (PDB: 3OG7)

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Ligands
Code	Name		Style	Show	Link
032	N-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-B]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide				PoSSuM

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Download interaction data: 3OG7

Code :

3OG7 PDBj RCSB PDB PDBe

Header :

transferase/transferase inhibitor

Title :

B-Raf Kinase V600E oncogenic mutant in complex with PLX4032

Release Data :

2010-09-22

Compound :

mol_id	molecule	chains	synonym
1	AKAP9-BRAF fusion protein	A,B	Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1
	ec: 2.7.11.1 fragment: Kinase domain (unp residues 1175-1446) mutation: I544A, I551K, Q562R, L588N, K630S, F667E, Y673S, A688R, L706S, A688R, L706S, Q709R, S713E, L716E, S720E

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: BRAF, BRAF1, RAFB1

Authors :

Zhang, Y., Zhang, K.Y., Zhang, C.

Keywords :

B-Raf, BRAF, PROTO-ONCOGENE, V600E, Kinase, TRANSFERASE, transferase-transferase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.4500 Å )

Citation :

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.

Bollag, G.,Hirth, P.,Tsai, J. et al.
(2010) Nature 467 : 596 - 599

PDB ID: 3OG7