Brand  (β version)

PDB ID: 2X6J

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Ligands
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093 N-(5-(4-chloro-3-(2-hydroxy-ethylsulfamoyl)- phenylthiazole-2-yl)-acetamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2X6J   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93
Release Data : 2010-04-07
Compound :
mol_id molecule chains synonym
1 PHOSPHOTIDYLINOSITOL 3 KINASE 59F A,B GH13170P, VPS34
ec: 2.7.1.137, 2.7.1.153, 2.7.1.154
fragment: HELICAL AND CATALYTIC DOMAINS, RESIDUES 258-949
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 DROSOPHILA MELANOGASTER  (taxid:7227) FRUIT FLY ESCHERICHIA COLI BL21(DE3)  (taxid:469008)
expression_system_variant: C41 RIPL
Authors : Miller, S., Tavshanjian, B., Oleksy, A., Perisic, O., Houseman, B.T., Shokat, K.M., Williams, R.L.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3.50 Å )
Citation :

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.

Miller, S.,Tavshanjian, B.,Oleksy, A.  et al.
(2010)  Science  327 : 1638

PubMed: 20339072
DOI: 10.1126/SCIENCE.1184429

Reaction

Chain : A, B
UniProt : Q9W1M7 (Q9W1M7_DROME)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) 2.7.1.137 ARBA:ARBA00023985
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