ID 2X6JA STANDARD; PRT; 696 AA. DT CONVERTED FROM PDB (SEQRES) 2X6J DE PHOSPHOTIDYLINOSITOL 3 KINASE 59F OS DROSOPHILA MELANOGASTER CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.500 CC R-Factor 0.232 FT #SUB 552 805 ASP A 693 946 TYR B Protein B 3 FT #SUB 553 806 ARG A 693 946 TYR B Protein B 4 FT #SUB 553 806 ARG A 694 947 TRP B Protein B 2 FT #SUB 554 807 HIS A 694 947 TRP B Protein B 2 FT #SUB 555 808 LEU A 694 947 TRP B Protein S 1 FT #SUB 578 831 ASP A 693 946 TYR B Protein S 5 FT #SUB 580 833 LYS A 693 946 TYR B Protein S 2 FT #SUB 580 833 LYS A 696 949 LYS B Protein S 2 FT #SUB 582 835 MET A 689 942 ARG B Protein S 2 FT #SUB 582 835 MET A 690 943 PHE B Protein B 1 FT #SUB 583 836 PRO A 690 943 PHE B Protein B 5 FT #SUB 584 837 PRO A 690 943 PHE B Protein B 2 FT #SUB 584 837 PRO A 693 946 TYR B Protein S 5 FT #SUB 588 841 LEU A 694 947 TRP B Protein B 6 FT #SUB 589 842 SER A 694 947 TRP B Protein B 4 FT #SUB 662 915 GLU A 662 915 GLU B Protein S 1 FT #SUB 665 918 VAL A 666 919 GLN B Protein S 2 FT #SUB 666 919 GLN A 665 918 VAL B Protein S 1 FT #SUB 666 919 GLN A 669 922 GLN B Protein A 4 FT #SUB 669 922 GLN A 666 919 GLN B Protein S 9 FT #SUB 669 922 GLN A 669 922 GLN B Protein S 3 FT #SUB 677 930 THR A 687 940 ILE B Protein S 1 FT #SUB 678 931 ALA A 687 940 ILE B Protein A 2 FT #SUB 678 931 ALA A 690 943 PHE B Protein S 1 FT #SUB 678 931 ALA A 691 944 THR B Protein A 8 FT #SUB 679 932 VAL A 694 947 TRP B Protein S 1 FT #SUB 684 937 VAL A 687 940 ILE B Protein S 1 FT #SUB 686 939 GLN A 582 835 MET B Protein S 2 FT #SUB 687 940 ILE A 677 930 THR B Protein S 1 FT #SUB 687 940 ILE A 678 931 ALA B Protein B 1 FT #SUB 689 942 ARG A 581 834 PRO B Protein S 2 FT #SUB 689 942 ARG A 582 835 MET B Protein S 1 FT #SUB 690 943 PHE A 582 835 MET B Protein S 3 FT #SUB 690 943 PHE A 583 836 PRO B Protein S 4 FT #SUB 690 943 PHE A 584 837 PRO B Protein A 9 FT #SUB 690 943 PHE A 585 838 PRO B Protein S 1 FT #SUB 690 943 PHE A 678 931 ALA B Protein A 2 FT #SUB 691 944 THR A 678 931 ALA B Protein A 7 FT #SUB 693 946 TYR A 552 805 ASP B Protein S 3 FT #SUB 693 946 TYR A 553 806 ARG B Protein S 4 FT #SUB 693 946 TYR A 578 831 ASP B Protein S 4 FT #SUB 693 946 TYR A 580 833 LYS B Protein A 3 FT #SUB 693 946 TYR A 583 836 PRO B Protein S 1 FT #SUB 693 946 TYR A 584 837 PRO B Protein S 6 FT #SUB 694 947 TRP A 555 808 LEU B Protein S 2 FT #SUB 694 947 TRP A 587 840 LYS B Protein S 2 FT #SUB 694 947 TRP A 588 841 LEU B Protein S 7 FT #SUB 694 947 TRP A 589 842 SER B Protein S 4 FT #HET 421 674 LYS A 1 1949 093 A S 1 FT #HET 422 675 SER A 1 1949 093 A S 1 FT #HET 426 679 PRO A 1 1949 093 A S 1 FT #HET 443 696 ILE A 1 1949 093 A S 2 FT #HET 445 698 LYS A 1 1949 093 A S 7 FT #HET 479 732 TYR A 1 1949 093 A S 2 FT #HET 491 744 LEU A 1 1949 093 A S 3 FT #HET 492 745 GLN A 1 1949 093 A B 1 FT #HET 493 746 TYR A 1 1949 093 A S 9 FT #HET 494 747 VAL A 1 1949 093 A A 9 FT #HET 496 749 SER A 1 1949 093 A A 5 FT #HET 557 810 ASN A 1 1949 093 A S 1 FT #HET 559 812 LEU A 1 1949 093 A S 1 FT #HET 569 822 ILE A 1 1949 093 A S 7 FT #HET 570 823 ASP A 1 1949 093 A S 6 FT DISORDER 1 37 FT DISORDER 170 277 FT DISORDER 309 313 FT DISORDER 696 696 CC SEQUENCE 545 AA (ATOM); CC ASIRDQLHTI VYRYPPTYVL SSEEQDLVWK FRFYLSSHKK ALTKFLKCIN WKLEDEVTQA CC LWMLANWAPM DVEDALELLS PTFTHPQVRK YAVSRLAQAP DEDLLLYLLQ LVQALKYEDP CC RHIVHLHGCI FPANLCTFLI QRACTNATLA NYFYWYLSIE VEEKQDERAH DMYAMVLKMF CC LKVLENGNFN LRGIFYNLRK QRRFIDELVK LVKLVAKEPG NRNKKTEKFQ KLLAEQDMFK CC VNFTNFEPIP FPLDPEIYIT KIVPMRTSLF KSALMPAKLT FVTSIAHHEY AAIFKHGDDL CC RQDQLILQMI TLMDKLLRRE NLDLKLTPYK VLATSSKHGF LQYVDSCTVA EVLAREGNIH CC NFFRKHHPCD NGPYGISAEV MDTYIKSCAG YCVITYLLGV GDRHLDNLLL TTNGKLFHID CC FGYILGRDPK PMPPPMKLSK EMVEAMGGIS SEHHHEFRKQ CYTAYLHLRR HANVMLNLFS CC LMVDATVPDI ALEPDKAVKK VEENLQLGLT DEEAVQHLQS LLDVSITAVM PALVEQIHRF CC TQYWR CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYR CC ATOM -------------------------------------ASIRDQLHTIVYR CC ************* CC SEQRES YPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWM CC ATOM YPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWM CC ************************************************** CC SEQRES LANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQ CC ATOM LANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQ CC ************************************************** CC SEQRES ALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGL CC ATOM ALKYEDPRHIVHLHGCIFP------------------------------- CC ******************* CC SEQRES HASVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPAT CC ATOM -------------------------------------------------- CC CC SEQRES PGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYW CC ATOM ---------------------------ANLCTFLIQRACTNATLANYFYW CC *********************** CC SEQRES YLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRK CC ATOM YLSIEVEE-----KQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRK CC ******** ************************************* CC SEQRES QRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIP CC ATOM QRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIP CC ************************************************** CC SEQRES FPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDL CC ATOM FPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDL CC ************************************************** CC SEQRES RQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVA CC ATOM RQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVA CC ************************************************** CC SEQRES EVLAREGNIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGV CC ATOM EVLAREGNIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGV CC ************************************************** CC SEQRES GDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVEAMGGIS CC ATOM GDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVEAMGGIS CC ************************************************** CC SEQRES SEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKK CC ATOM SEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKK CC ************************************************** CC SEQRES VEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK CC ATOM VEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWR- CC ********************************************* SQ SEQUENCE 696 AA; MW; CN; GSHMDSEIQM ENLVERKHHR LARSERSGIS DRDAKPTASI RDQLHTIVYR YPPTYVLSSE EQDLVWKFRF YLSSHKKALT KFLKCINWKL EDEVTQALWM LANWAPMDVE DALELLSPTF THPQVRKYAV SRLAQAPDED LLLYLLQLVQ ALKYEDPRHI VHLHGCIFPE RDVVRSILDD NGSLLDQSSL SDLSATSSGL HASVIPANQR AASVLAAIKS DKSVSPGSAG GSGSGGQGSV ALPNPSAPAT PGSSSLPCDS NSNALMLAEG ISFGSVPANL CTFLIQRACT NATLANYFYW YLSIEVEEVE SVRKQDERAH DMYAMVLKMF LKVLENGNFN LRGIFYNLRK QRRFIDELVK LVKLVAKEPG NRNKKTEKFQ KLLAEQDMFK VNFTNFEPIP FPLDPEIYIT KIVPMRTSLF KSALMPAKLT FVTSIAHHEY AAIFKHGDDL RQDQLILQMI TLMDKLLRRE NLDLKLTPYK VLATSSKHGF LQYVDSCTVA EVLAREGNIH NFFRKHHPCD NGPYGISAEV MDTYIKSCAG YCVITYLLGV GDRHLDNLLL TTNGKLFHID FGYILGRDPK PMPPPMKLSK EMVEAMGGIS SEHHHEFRKQ CYTAYLHLRR HANVMLNLFS LMVDATVPDI ALEPDKAVKK VEENLQLGLT DEEAVQHLQS LLDVSITAVM PALVEQIHRF TQYWRK // ID 2X6JB STANDARD; PRT; 696 AA. DT CONVERTED FROM PDB (SEQRES) 2X6J DE PHOSPHOTIDYLINOSITOL 3 KINASE 59F OS DROSOPHILA MELANOGASTER CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.500 CC R-Factor 0.232 FT #SUB 552 805 ASP B 693 946 TYR A Protein B 3 FT #SUB 553 806 ARG B 693 946 TYR A Protein B 4 FT #SUB 555 808 LEU B 694 947 TRP A Protein S 2 FT #SUB 578 831 ASP B 693 946 TYR A Protein S 4 FT #SUB 580 833 LYS B 693 946 TYR A Protein S 3 FT #SUB 581 834 PRO B 689 942 ARG A Protein S 2 FT #SUB 582 835 MET B 686 939 GLN A Protein S 2 FT #SUB 582 835 MET B 689 942 ARG A Protein S 1 FT #SUB 582 835 MET B 690 943 PHE A Protein B 3 FT #SUB 583 836 PRO B 690 943 PHE A Protein B 4 FT #SUB 583 836 PRO B 693 946 TYR A Protein B 1 FT #SUB 584 837 PRO B 690 943 PHE A Protein A 9 FT #SUB 584 837 PRO B 693 946 TYR A Protein S 6 FT #SUB 585 838 PRO B 690 943 PHE A Protein S 1 FT #SUB 587 840 LYS B 694 947 TRP A Protein A 2 FT #SUB 588 841 LEU B 694 947 TRP A Protein B 7 FT #SUB 589 842 SER B 694 947 TRP A Protein A 4 FT #SUB 662 915 GLU B 662 915 GLU A Protein S 1 FT #SUB 665 918 VAL B 666 919 GLN A Protein S 1 FT #SUB 666 919 GLN B 665 918 VAL A Protein S 2 FT #SUB 666 919 GLN B 669 922 GLN A Protein A 9 FT #SUB 669 922 GLN B 666 919 GLN A Protein S 4 FT #SUB 669 922 GLN B 669 922 GLN A Protein S 3 FT #SUB 677 930 THR B 687 940 ILE A Protein S 1 FT #SUB 678 931 ALA B 687 940 ILE A Protein S 1 FT #SUB 678 931 ALA B 690 943 PHE A Protein S 2 FT #SUB 678 931 ALA B 691 944 THR A Protein A 7 FT #SUB 687 940 ILE B 677 930 THR A Protein S 1 FT #SUB 687 940 ILE B 678 931 ALA A Protein A 2 FT #SUB 687 940 ILE B 684 937 VAL A Protein S 1 FT #SUB 689 942 ARG B 582 835 MET A Protein S 2 FT #SUB 690 943 PHE B 582 835 MET A Protein S 1 FT #SUB 690 943 PHE B 583 836 PRO A Protein S 5 FT #SUB 690 943 PHE B 584 837 PRO A Protein S 2 FT #SUB 690 943 PHE B 678 931 ALA A Protein S 1 FT #SUB 691 944 THR B 678 931 ALA A Protein A 8 FT #SUB 693 946 TYR B 552 805 ASP A Protein S 3 FT #SUB 693 946 TYR B 553 806 ARG A Protein S 4 FT #SUB 693 946 TYR B 578 831 ASP A Protein S 5 FT #SUB 693 946 TYR B 580 833 LYS A Protein S 2 FT #SUB 693 946 TYR B 584 837 PRO A Protein S 5 FT #SUB 694 947 TRP B 553 806 ARG A Protein S 2 FT #SUB 694 947 TRP B 554 807 HIS A Protein S 2 FT #SUB 694 947 TRP B 555 808 LEU A Protein S 1 FT #SUB 694 947 TRP B 588 841 LEU A Protein S 6 FT #SUB 694 947 TRP B 589 842 SER A Protein S 4 FT #SUB 694 947 TRP B 679 932 VAL A Protein S 1 FT #SUB 696 949 LYS B 580 833 LYS A Protein S 2 FT #HET 420 673 PHE B 2 1950 093 B S 1 FT #HET 422 675 SER B 2 1950 093 B S 4 FT #HET 426 679 PRO B 2 1950 093 B S 2 FT #HET 443 696 ILE B 2 1950 093 B S 1 FT #HET 445 698 LYS B 2 1950 093 B S 3 FT #HET 479 732 TYR B 2 1950 093 B S 8 FT #HET 491 744 LEU B 2 1950 093 B S 4 FT #HET 492 745 GLN B 2 1950 093 B B 1 FT #HET 493 746 TYR B 2 1950 093 B S 7 FT #HET 494 747 VAL B 2 1950 093 B A 7 FT #HET 496 749 SER B 2 1950 093 B A 8 FT #HET 559 812 LEU B 2 1950 093 B S 2 FT #HET 569 822 ILE B 2 1950 093 B S 3 FT #HET 570 823 ASP B 2 1950 093 B S 3 FT DISORDER 1 37 FT DISORDER 171 277 FT DISORDER 308 313 CC SEQUENCE 546 AA (ATOM); CC ASIRDQLHTI VYRYPPTYVL SSEEQDLVWK FRFYLSSHKK ALTKFLKCIN WKLEDEVTQA CC LWMLANWAPM DVEDALELLS PTFTHPQVRK YAVSRLAQAP DEDLLLYLLQ LVQALKYEDP CC RHIVHLHGCI FPEANLCTFL IQRACTNATL ANYFYWYLSI EVEKQDERAH DMYAMVLKMF CC LKVLENGNFN LRGIFYNLRK QRRFIDELVK LVKLVAKEPG NRNKKTEKFQ KLLAEQDMFK CC VNFTNFEPIP FPLDPEIYIT KIVPMRTSLF KSALMPAKLT FVTSIAHHEY AAIFKHGDDL CC RQDQLILQMI TLMDKLLRRE NLDLKLTPYK VLATSSKHGF LQYVDSCTVA EVLAREGNIH CC NFFRKHHPCD NGPYGISAEV MDTYIKSCAG YCVITYLLGV GDRHLDNLLL TTNGKLFHID CC FGYILGRDPK PMPPPMKLSK EMVEAMGGIS SEHHHEFRKQ CYTAYLHLRR HANVMLNLFS CC LMVDATVPDI ALEPDKAVKK VEENLQLGLT DEEAVQHLQS LLDVSITAVM PALVEQIHRF CC TQYWRK CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSHMDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYR CC ATOM -------------------------------------ASIRDQLHTIVYR CC ************* CC SEQRES YPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWM CC ATOM YPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWM CC ************************************************** CC SEQRES LANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQ CC ATOM LANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQ CC ************************************************** CC SEQRES ALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGL CC ATOM ALKYEDPRHIVHLHGCIFPE------------------------------ CC ******************** CC SEQRES HASVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPAT CC ATOM -------------------------------------------------- CC CC SEQRES PGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYW CC ATOM ---------------------------ANLCTFLIQRACTNATLANYFYW CC *********************** CC SEQRES YLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRK CC ATOM YLSIEVE------KQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRK CC ******* ************************************* CC SEQRES QRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIP CC ATOM QRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIP CC ************************************************** CC SEQRES FPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDL CC ATOM FPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDL CC ************************************************** CC SEQRES RQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVA CC ATOM RQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVA CC ************************************************** CC SEQRES EVLAREGNIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGV CC ATOM EVLAREGNIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGV CC ************************************************** CC SEQRES GDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVEAMGGIS CC ATOM GDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVEAMGGIS CC ************************************************** CC SEQRES SEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKK CC ATOM SEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKK CC ************************************************** CC SEQRES VEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK CC ATOM VEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK CC ********************************************** SQ SEQUENCE 696 AA; MW; CN; GSHMDSEIQM ENLVERKHHR LARSERSGIS DRDAKPTASI RDQLHTIVYR YPPTYVLSSE EQDLVWKFRF YLSSHKKALT KFLKCINWKL EDEVTQALWM LANWAPMDVE DALELLSPTF THPQVRKYAV SRLAQAPDED LLLYLLQLVQ ALKYEDPRHI VHLHGCIFPE RDVVRSILDD NGSLLDQSSL SDLSATSSGL HASVIPANQR AASVLAAIKS DKSVSPGSAG GSGSGGQGSV ALPNPSAPAT PGSSSLPCDS NSNALMLAEG ISFGSVPANL CTFLIQRACT NATLANYFYW YLSIEVEEVE SVRKQDERAH DMYAMVLKMF LKVLENGNFN LRGIFYNLRK QRRFIDELVK LVKLVAKEPG NRNKKTEKFQ KLLAEQDMFK VNFTNFEPIP FPLDPEIYIT KIVPMRTSLF KSALMPAKLT FVTSIAHHEY AAIFKHGDDL RQDQLILQMI TLMDKLLRRE NLDLKLTPYK VLATSSKHGF LQYVDSCTVA EVLAREGNIH NFFRKHHPCD NGPYGISAEV MDTYIKSCAG YCVITYLLGV GDRHLDNLLL TTNGKLFHID FGYILGRDPK PMPPPMKLSK EMVEAMGGIS SEHHHEFRKQ CYTAYLHLRR HANVMLNLFS LMVDATVPDI ALEPDKAVKK VEENLQLGLT DEEAVQHLQS LLDVSITAVM PALVEQIHRF TQYWRK //