Brand  (β version)

PDB ID: 2MPA

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Ligands
Code Name Style Show Link
CD Cadmium ion PoSSuM
Non-standard Residues
Code Name Show
CYF 5-[2-(2-amino-2-carbamoyl-ethylsulfanyl)-acetylamino]-2-(3,6-dihydroxy-9,9a-dihydro-3h-xanthen-9-yl)-benzoic acid
THC N-methylcarbonylthreonine
Glycosylation
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Structure summary

Code : 2MPA   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM
Title : BACTERICIDAL ANTIBODY AGAINST NEISSERIA MENINGITIDIS
Release Data : 1999-06-23
Compound :
mol_id molecule chains
1 MN12H2 IGG2A-KAPPA, light chain L
fragment: FAB FRAGMENT
mol_id molecule chains
2 MN12H2 IGG2A-KAPPA,heavy chain H
fragment: FAB FRAGMENT
mol_id molecule chains synonym
3 CONJUGATE OF PORA P1.16 PEPTIDE WITH FLUORESCEIN P P1.16, AC-TKDTNNNLC(FLUORESCEIN)-NH2
fragment: APEX OF EXTRACELLULAR LOOP 4 (VR2) OF PORA, RESIDUES 180 - 187
Source :
mol_id organism_scientific organism_common
1 Mus musculus  (taxid:10090) Mouse
strain: BALB/C
cell_line: MN12H2 MURINE-MURINE HYBRIDOMA
cell: B-LYMPHOCYTE HYBRIDOMA
mol_id organism_scientific organism_common
2 Mus musculus  (taxid:10090) Mouse
strain: BALB/C
cell_line: MN12H2 MURINE-MURINE HYBRIDOMA
cell: B-LYMPHOCYTE HYBRIDOMA
mol_id organism_scientific
3 Synthetic construct  (taxid:32630 )
synthetic: yes
other_details: SEQUENCE FROM NEISSERIA MENINGITIDIS (MENINGOCOCCUS), STRAIN: H44/76, VARIANT: P1.16;
Authors : Van Den Elsen, J.M.H., Herron, J.N., Kroon, J., Gros, P.
Keywords : MURINE IMMUNOGLOBULIN IGG2A KAPPA, BACTERICIDAL ANTIBODY, EPITOPE P1.16 OF PORA FROM NEISSERIA MENINGITIDIS, COMPLEX (IMMUNOGLOBULIN-PEPTIDE), IMMUNE SYSTEM
Exp. method : X-RAY DIFFRACTION ( 2.6 Å )
Citation :

Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide.

van den Elsen, J.M.,Herron, J.N.,Hoogerhout, P.  et al.
(1997)  Proteins  29 : 113 - 125

PubMed: 9294871
DOI: 10.1002/(SICI)1097-0134(199709)29:1<113::AID-PROT9>3.3.CO;2-U

Bactericidal Antibody Recognition of Meningococcal Pora by Induced Fit: Comparison of Liganded and Unliganded Fab Structures

van den Elsen, J.,Vandeputte-Rutten, L.,Kroon, J.  et al.
(1999)  J.Biol.Chem.  3 : 1495

DOI: 10.1074/jbc.274.3.1495

Reaction

Chain : L
UniProt : P01837 (IGKC_MOUSE)
Reaction : -
Chain : H
UniProt : P84751 (HVM63_MOUSE)
Reaction : -