Het-PDB Navi2 (PDB: 2F9A)

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Ligands
Code	Name		Style	Show	Link
F24	(7r,12r,13r)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid				PoSSuM

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Download interaction data: 2F9A

Code :

2F9A PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

HMG-CoA synthase from Brassica juncea in complex with F-244

Release Data :

2006-07-25

Compound :

mol_id	molecule	chains
1	3-Hydroxy-3-methylglutaryl coenzyme A synthase 1	A

Source :

mol_id	organism_scientific	expression_system
1	Brassica juncea (taxid:3707)	Escherichia coli BL21(DE3) (taxid:469008)
	expression_system_strain: BL21 (DE3) expression_system_vector_type: plasmid expression_system_plasmid: pHis8

Authors :

Pojer, F., Ferrer, J.L., Richard, S.B., Noel, J.P.

Keywords :

HMGS1, F-244, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.51 Å )

Citation :

Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.

Pojer, F.,Ferrer, J.L.,Richard, S.B. et al.
(2006) Proc.Natl.Acad.Sci.Usa 103 : 11491 - 11496

Chain :

UniProt :

Q9M6U3 (Q9M6U3_BRAJU)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3- methylglutaryl-CoA + CoA + H(+)	2.3.3.10	RuleBase:RU364071
	-	RuleBase:RU364071

PDB ID: 2F9A