PDB ID: 2VA5
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Structure summary
Code : | 2VA5 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | X-ray crystal structure of beta secretase complexed with compound 8c | ||||||||||||
Release Data : | 2007-11-13 | ||||||||||||
Compound : |
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Source : |
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Authors : | Edwards, P.D., Albert, J.S., Sylvester, M., Aharony, D., Andisik, D., Callaghan, O., Campbell, J.B., Carr, R.A., Chessari, G., Congreve, M., Frederickson, M., Folmer, R.H.A., Geschwindner, S., Koether, G., Kolmodin, K., Krumrine, J., Mauger, R.C., Murray, C.W., Olsson, L., Patel, S., Spear, N., Tian, G. | ||||||||||||
Keywords : | BASE, ZYMOGEN, PROTEASE, MEMBRANE, HYDROLASE, ALZHEIMER'S DISEASE, ALTERNATIVE SPLICING, MEMAPSIN 2, GLYCOPROTEIN, TRANSMEMBRANE, BETA-SECRETASE, ASPARTYL PROTEASE, ASPARTIC PROTEASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.75 Å ) | ||||||||||||
Citation : |
Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine Beta-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency.
Edwards, P.D.,Albert, J.S.,Sylvester, M.
et al.
PubMed: 17985862 |
Reaction
Chain : | A | ||||||||
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UniProt : | P56817 (BACE1_HUMAN) | ||||||||
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