Brand  (β version)

PDB ID: 2JIH

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Ligands
Code Name Style Show Link
097 (2s,3r)-N~4~-[(1s)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide PoSSuM
ZN Zinc ion PoSSuM
CD Cadmium ion PoSSuM
NI Nickel (II) ion PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2JIH   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of Human ADAMTS-1 catalytic Domain and Cysteine- Rich Domain (complex-form)
Release Data : 2008-01-15
Compound :
mol_id molecule chains synonym
1 ADAMTS-1 A,B A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 1, ADAM-TS 1, ADAM-TS1, METH-1
fragment: CATALYTIC DOMAIN AND CYSTEINE-RICH DOMAIN, RESIDUES 253-548
other_details: MARIMASTAT (N4-(2,2-DIMETHYL-1-METHYLCARBAMOYL-PROPYL)-2, N1-DIHYDROXY-3-ISOBUTYL-SUCCINAMIDE)
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_cell_line: Sf21
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PFASTBAC
Authors : Gerhardt, S., Hassall, G., Hawtin, P., McCall, E., Flavell, L., Minshull, C., Hargreaves, D., Ting, A., Pauptit, R.A., Parker, A.E., Abbott, W.M.
Keywords : ZINC, ZYMOGEN, PROTEASE, ADAMTS-1, HYDROLASE, METALLOPROTEASE, HEPARIN-BINDING, METALLOPROTEINASE, METZINCIN, POLYMORPHISM, GLYCOPROTEIN, METAL-BINDING, EXTRACELLULAR MATRIX, CLEAVAGE ON PAIR OF BASIC RESIDUES
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains.

Gerhardt, S.,Hassall, G.,Hawtin, P.  et al.
(2007)  J. Mol. Biol.  373 : 891 - 902

PubMed: 17897672
DOI: 10.1016/j.jmb.2007.07.047

Reaction

Chain : A, B
UniProt : Q9UHI8 (ATS1_HUMAN)
Reaction : -