Het-PDB Navi2 (PDB: 2FB8)

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Ligands
Code	Name		Style	Show	Link
215	(1z)-5-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5-pyridin-4-yl-1h-imidazol-4-yl)indan-1-one oxime				PoSSuM

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Download interaction data: 2FB8

Code :

2FB8 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Structure of the B-Raf kinase domain bound to SB-590885

Release Data :

2006-12-12

Compound :

mol_id	molecule	chains	synonym
1	B-Raf proto-oncogene serine/threonine-protein kinase	A,B	p94, v-Raf murine sarcoma viral oncogene homolog B1
	ec: 2.7.1.37 fragment: B-Raf kinase domain, residues 445-723

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: BRAF, BRAF1, RAFB1 expression_system_common: Fall armyworm expression_system_cell_line: Sf-9 expression_system_vector_type: Baculovirus expression_system_plasmid: pACGP67

Authors :

Lougheed, J.C., Lee, J., Chau, D.C., Stout, T.J.

Keywords :

kinase domain, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.900 Å )

Citation :

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.

King, A.J.,Patrick, D.R.,Batorsky, R.S. et al.
(2006) Cancer Res. 66 : 11100 - 11105

Chain :

A, B

UniProt :

P15056 (BRAF_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	PubMed:21441910, PubMed:29433126
	-	PubMed:21441910, PubMed:29433126
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	PubMed:21441910
	-	PubMed:21441910

PDB ID: 2FB8