Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
215 (1z)-5-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5-pyridin-4-yl-1h-imidazol-4-yl)indan-1-one oxime
Code : 2FB8
Header : TRANSFERASE
Title : Structure of the B-Raf kinase domain bound to SB-590885
Release Data : 2006-12-12
Compound :
mol_id molecule chains synonym
1 B-Raf proto-oncogene serine/threonine-protein kinase A,B p94, v-Raf murine sarcoma viral oncogene homolog B1
ec: 2.7.1.37
fragment: B-Raf kinase domain, residues 445-723
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: BRAF, BRAF1, RAFB1
expression_system_common: Fall armyworm
expression_system_cell_line: Sf-9
expression_system_vector_type: Baculovirus
expression_system_plasmid: pACGP67
Authors : Lougheed, J.C., Lee, J., Chau, D.C., Stout, T.J.
Keywords : kinase domain, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.900 Å )
Citation :

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.

King, A.J.,Patrick, D.R.,Batorsky, R.S.  et al.
(2006)  Cancer Res.  66 : 11100 - 11105

PubMed: 17145850
DOI: 10.1158/0008-5472.CAN-06-2554

Chain : A, B
UniProt : P15056 (BRAF_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.