ID	2FB8A	STANDARD;	PRT;	281	AA.
DT	CONVERTED FROM PDB (SEQRES) 2FB8
DE	B-Raf proto-oncogene serine/threonine-protein kinase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.900
CC	R-Factor	0.203
FT	#SUB	8	 450 	TRP	A	64	 506 	ARG	B	Protein	S	2
FT	#SUB	8	 450 	TRP	A	65	 507 	LYS	B	Protein	S	3
FT	#SUB	8	 450 	TRP	A	66	 508 	THR	B	Protein	S	1
FT	#SUB	8	 450 	TRP	A	67	 509 	ARG	B	Protein	S	9
FT	#SUB	8	 450 	TRP	A	128	 570 	LYS	B	Protein	S	1
FT	#SUB	35	 477 	HIS	A	68	 510 	HIS	B	Protein	B	3
FT	#SUB	35	 477 	HIS	A	120	 562 	GLN	B	Protein	B	6
FT	#SUB	35	 477 	HIS	A	123	 565 	ASP	B	Protein	S	3
FT	#SUB	35	 477 	HIS	A	124	 566 	TYR	B	Protein	S	1
FT	#SUB	35	 477 	HIS	A	127	 569 	ALA	B	Protein	S	2
FT	#SUB	36	 478 	GLY	A	120	 562 	GLN	B	Protein	B	5
FT	#SUB	63	 505 	LEU	A	67	 509 	ARG	B	Protein	B	2
FT	#SUB	64	 506 	ARG	A	8	 450 	TRP	B	Protein	B	1
FT	#SUB	64	 506 	ARG	A	67	 509 	ARG	B	Protein	B	3
FT	#SUB	65	 507 	LYS	A	8	 450 	TRP	B	Protein	B	3
FT	#SUB	66	 508 	THR	A	67	 509 	ARG	B	Protein	B	4
FT	#SUB	67	 509 	ARG	A	8	 450 	TRP	B	Protein	S	11
FT	#SUB	67	 509 	ARG	A	64	 506 	ARG	B	Protein	S	2
FT	#SUB	67	 509 	ARG	A	66	 508 	THR	B	Protein	S	5
FT	#SUB	67	 509 	ARG	A	67	 509 	ARG	B	Protein	S	5
FT	#SUB	67	 509 	ARG	A	73	 515 	LEU	B	Protein	S	1
FT	#SUB	67	 509 	ARG	A	74	 516 	PHE	B	Protein	S	11
FT	#SUB	67	 509 	ARG	A	75	 517 	MET	B	Protein	B	1
FT	#SUB	68	 510 	HIS	A	35	 477 	HIS	B	Protein	S	5
FT	#SUB	68	 510 	HIS	A	73	 515 	LEU	B	Protein	B	1
FT	#SUB	69	 511 	VAL	A	88	 530 	GLN	B	Protein	S	1
FT	#SUB	73	 515 	LEU	A	67	 509 	ARG	B	Protein	S	1
FT	#SUB	73	 515 	LEU	A	68	 510 	HIS	B	Protein	S	1
FT	#SUB	74	 516 	PHE	A	67	 509 	ARG	B	Protein	A	12
FT	#SUB	75	 517 	MET	A	67	 509 	ARG	B	Protein	B	1
FT	#SUB	75	 517 	MET	A	68	 510 	HIS	B	Protein	S	1
FT	#SUB	75	 517 	MET	A	69	 511 	VAL	B	Protein	S	1
FT	#SUB	88	 530 	GLN	A	69	 511 	VAL	B	Protein	S	1
FT	#SUB	120	 562 	GLN	A	35	 477 	HIS	B	Protein	S	4
FT	#SUB	120	 562 	GLN	A	36	 478 	GLY	B	Protein	S	3
FT	#SUB	123	 565 	ASP	A	35	 477 	HIS	B	Protein	S	3
FT	#SUB	124	 566 	TYR	A	34	 476 	TRP	B	Protein	S	2
FT	#SUB	127	 569 	ALA	A	35	 477 	HIS	B	Protein	S	2
FT	#SUB	128	 570 	LYS	A	34	 476 	TRP	B	Protein	S	1
FT	#SUB	144	 586 	GLU	A	146	 588 	LEU	B	Protein	S	1
FT	#HET	21	 463 	ILE	A	1	102 	215	A	A	9
FT	#HET	22	 464 	GLY	A	1	102 	215	A	B	2
FT	#HET	29	 471 	VAL	A	1	102 	215	A	S	8
FT	#HET	39	 481 	ALA	A	1	102 	215	A	A	4
FT	#HET	41	 483 	LYS	A	1	102 	215	A	S	6
FT	#HET	59	 501 	GLU	A	1	102 	215	A	S	2
FT	#HET	72	 514 	LEU	A	1	102 	215	A	S	1
FT	#HET	87	 529 	THR	A	1	102 	215	A	S	3
FT	#HET	88	 530 	GLN	A	1	102 	215	A	B	1
FT	#HET	89	 531 	TRP	A	1	102 	215	A	A	4
FT	#HET	90	 532 	CYS	A	1	102 	215	A	A	10
FT	#HET	141	 583 	PHE	A	1	102 	215	A	S	16
FT	#HET	152	 594 	ASP	A	1	102 	215	A	A	7
FT	#HET	153	 595 	PHE	A	1	102 	215	A	B	1
FT	DISORDER	1	6
FT	DISORDER	159	171
FT	DISORDER	279	281
CC	SEQUENCE	259 AA (ATOM);
CC	DWEIPDGQIT VGQRIGSGSF GTVYKGKWHG DVAVKMLNVT APTPQQLQAF KNEVGVLRKT
CC	RHVNILLFMG YSTKPQLAIV TQWCEGSSLY HHLHIIETKF EMIKLIDIAR QTAQGMDYLH
CC	AKSIIHRDLK SNNIFLHEDL TVKIGDFGLA TVSGSILWMA PEVIRMQDKN PYSFQSDVYA
CC	FGIVLYELMT GQLPYSNINN RDQIIFMVGR GYLSPDLSKV RSNCPKAMKR LMAECLKKKR
CC	DERPLFPQIL ASIELLARS
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GSDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
CC	ATOM   ------DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
CC	             ********************************************
CC	SEQRES QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
CC	ATOM   QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
CC	       **************************************************
CC	SEQRES IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI
CC	ATOM   IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI
CC	       **************************************************
CC	SEQRES GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAF
CC	ATOM   GDFGLATV-------------SGSILWMAPEVIRMQDKNPYSFQSDVYAF
CC	       ********             *****************************
CC	SEQRES GIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL
CC	ATOM   GIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL
CC	       **************************************************
CC	SEQRES MAECLKKKRDERPLFPQILASIELLARSLPK
CC	ATOM   MAECLKKKRDERPLFPQILASIELLARS---
CC	       ****************************   
SQ	SEQUENCE	281 AA;      MW;         CN;
	GSDSSDDWEI PDGQITVGQR IGSGSFGTVY KGKWHGDVAV KMLNVTAPTP QQLQAFKNEV
	GVLRKTRHVN ILLFMGYSTK PQLAIVTQWC EGSSLYHHLH IIETKFEMIK LIDIARQTAQ
	GMDYLHAKSI IHRDLKSNNI FLHEDLTVKI GDFGLATVKS RWSGSHQFEQ LSGSILWMAP
	EVIRMQDKNP YSFQSDVYAF GIVLYELMTG QLPYSNINNR DQIIFMVGRG YLSPDLSKVR
	SNCPKAMKRL MAECLKKKRD ERPLFPQILA SIELLARSLP K
//
ID	2FB8B	STANDARD;	PRT;	281	AA.
DT	CONVERTED FROM PDB (SEQRES) 2FB8
DE	B-Raf proto-oncogene serine/threonine-protein kinase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.900
CC	R-Factor	0.203
FT	#SUB	8	 450 	TRP	B	64	 506 	ARG	A	Protein	S	1
FT	#SUB	8	 450 	TRP	B	65	 507 	LYS	A	Protein	S	3
FT	#SUB	8	 450 	TRP	B	67	 509 	ARG	A	Protein	S	11
FT	#SUB	34	 476 	TRP	B	124	 566 	TYR	A	Protein	S	2
FT	#SUB	34	 476 	TRP	B	128	 570 	LYS	A	Protein	S	1
FT	#SUB	35	 477 	HIS	B	68	 510 	HIS	A	Protein	A	5
FT	#SUB	35	 477 	HIS	B	120	 562 	GLN	A	Protein	B	4
FT	#SUB	35	 477 	HIS	B	123	 565 	ASP	A	Protein	S	3
FT	#SUB	35	 477 	HIS	B	127	 569 	ALA	A	Protein	S	2
FT	#SUB	36	 478 	GLY	B	120	 562 	GLN	A	Protein	B	3
FT	#SUB	64	 506 	ARG	B	8	 450 	TRP	A	Protein	B	2
FT	#SUB	64	 506 	ARG	B	67	 509 	ARG	A	Protein	B	2
FT	#SUB	65	 507 	LYS	B	8	 450 	TRP	A	Protein	B	3
FT	#SUB	66	 508 	THR	B	8	 450 	TRP	A	Protein	B	1
FT	#SUB	66	 508 	THR	B	67	 509 	ARG	A	Protein	B	5
FT	#SUB	67	 509 	ARG	B	8	 450 	TRP	A	Protein	S	9
FT	#SUB	67	 509 	ARG	B	63	 505 	LEU	A	Protein	S	2
FT	#SUB	67	 509 	ARG	B	64	 506 	ARG	A	Protein	S	3
FT	#SUB	67	 509 	ARG	B	66	 508 	THR	A	Protein	S	4
FT	#SUB	67	 509 	ARG	B	67	 509 	ARG	A	Protein	S	5
FT	#SUB	67	 509 	ARG	B	73	 515 	LEU	A	Protein	S	1
FT	#SUB	67	 509 	ARG	B	74	 516 	PHE	A	Protein	S	12
FT	#SUB	67	 509 	ARG	B	75	 517 	MET	A	Protein	S	1
FT	#SUB	68	 510 	HIS	B	35	 477 	HIS	A	Protein	S	3
FT	#SUB	68	 510 	HIS	B	73	 515 	LEU	A	Protein	B	1
FT	#SUB	68	 510 	HIS	B	75	 517 	MET	A	Protein	B	1
FT	#SUB	69	 511 	VAL	B	75	 517 	MET	A	Protein	B	1
FT	#SUB	69	 511 	VAL	B	88	 530 	GLN	A	Protein	S	1
FT	#SUB	73	 515 	LEU	B	67	 509 	ARG	A	Protein	S	1
FT	#SUB	73	 515 	LEU	B	68	 510 	HIS	A	Protein	S	1
FT	#SUB	74	 516 	PHE	B	67	 509 	ARG	A	Protein	A	11
FT	#SUB	75	 517 	MET	B	67	 509 	ARG	A	Protein	S	1
FT	#SUB	88	 530 	GLN	B	69	 511 	VAL	A	Protein	S	1
FT	#SUB	120	 562 	GLN	B	35	 477 	HIS	A	Protein	S	6
FT	#SUB	120	 562 	GLN	B	36	 478 	GLY	A	Protein	S	5
FT	#SUB	123	 565 	ASP	B	35	 477 	HIS	A	Protein	A	3
FT	#SUB	124	 566 	TYR	B	35	 477 	HIS	A	Protein	S	1
FT	#SUB	127	 569 	ALA	B	35	 477 	HIS	A	Protein	S	2
FT	#SUB	128	 570 	LYS	B	8	 450 	TRP	A	Protein	S	1
FT	#SUB	146	 588 	LEU	B	144	 586 	GLU	A	Protein	S	1
FT	#HET	21	 463 	ILE	B	2	101 	215	B	S	1
FT	#HET	29	 471 	VAL	B	2	101 	215	B	S	9
FT	#HET	39	 481 	ALA	B	2	101 	215	B	A	4
FT	#HET	41	 483 	LYS	B	2	101 	215	B	S	8
FT	#HET	59	 501 	GLU	B	2	101 	215	B	S	3
FT	#HET	85	 527 	ILE	B	2	101 	215	B	B	1
FT	#HET	87	 529 	THR	B	2	101 	215	B	S	3
FT	#HET	88	 530 	GLN	B	2	101 	215	B	B	1
FT	#HET	89	 531 	TRP	B	2	101 	215	B	A	11
FT	#HET	90	 532 	CYS	B	2	101 	215	B	A	8
FT	#HET	96	 538 	TYR	B	2	101 	215	B	S	5
FT	#HET	101	 543 	ILE	B	2	101 	215	B	S	2
FT	#HET	141	 583 	PHE	B	2	101 	215	B	S	10
FT	#HET	152	 594 	ASP	B	2	101 	215	B	A	4
FT	#HET	153	 595 	PHE	B	2	101 	215	B	B	1
FT	DISORDER	1	6
FT	DISORDER	159	171
FT	DISORDER	279	281
CC	SEQUENCE	259 AA (ATOM);
CC	DWEIPDGQIT VGQRIGSGSF GTVYKGKWHG DVAVKMLNVT APTPQQLQAF KNEVGVLRKT
CC	RHVNILLFMG YSTKPQLAIV TQWCEGSSLY HHLHIIETKF EMIKLIDIAR QTAQGMDYLH
CC	AKSIIHRDLK SNNIFLHEDL TVKIGDFGLA TVSGSILWMA PEVIRMQDKN PYSFQSDVYA
CC	FGIVLYELMT GQLPYSNINN RDQIIFMVGR GYLSPDLSKV RSNCPKAMKR LMAECLKKKR
CC	DERPLFPQIL ASIELLARS
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GSDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
CC	ATOM   ------DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
CC	             ********************************************
CC	SEQRES QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
CC	ATOM   QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
CC	       **************************************************
CC	SEQRES IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI
CC	ATOM   IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI
CC	       **************************************************
CC	SEQRES GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAF
CC	ATOM   GDFGLATV-------------SGSILWMAPEVIRMQDKNPYSFQSDVYAF
CC	       ********             *****************************
CC	SEQRES GIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL
CC	ATOM   GIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL
CC	       **************************************************
CC	SEQRES MAECLKKKRDERPLFPQILASIELLARSLPK
CC	ATOM   MAECLKKKRDERPLFPQILASIELLARS---
CC	       ****************************   
SQ	SEQUENCE	281 AA;      MW;         CN;
	GSDSSDDWEI PDGQITVGQR IGSGSFGTVY KGKWHGDVAV KMLNVTAPTP QQLQAFKNEV
	GVLRKTRHVN ILLFMGYSTK PQLAIVTQWC EGSSLYHHLH IIETKFEMIK LIDIARQTAQ
	GMDYLHAKSI IHRDLKSNNI FLHEDLTVKI GDFGLATVKS RWSGSHQFEQ LSGSILWMAP
	EVIRMQDKNP YSFQSDVYAF GIVLYELMTG QLPYSNINNR DQIIFMVGRG YLSPDLSKVR
	SNCPKAMKRL MAECLKKKRD ERPLFPQILA SIELLARSLP K
//