Het-PDB Navi2 (PDB: 2BLA)

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Ligands
Code	Name	Link
CP6	5-(4-chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine	PoSSuM
MES	2-(N-morpholino)-ethanesulfonic acid	PoSSuM
NDP	Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate	PoSSuM

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Download interaction data: 2BLA

Code :

2BLA PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

SP21 double mutant P. vivax Dihydrofolate reductase in complex with pyrimethamine

Release Data :

2005-09-07

Compound :

mol_id	molecule	chains	synonym
1	DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE	A	DIHYDROFOLATE REDUCTASE
	ec: 1.5.1.3

Source :

mol_id	organism_scientific	expression_system
1	PLASMODIUM VIVAX (taxid:5855)	ESCHERICHIA COLI (taxid:562)

Authors :

Kongsaeree, P., Khongsuk, P., Leartsakulpanich, U., Chitnumsub, P., Tarnchompoo, B., Walkinshaw, M.D., Yuthavong, Y.

Keywords :

DIHYDROFOLATE REDUCTASE, PLASMODIUM VIVAX, PYRIMETHAMINE, MALARIA, DRUG RESISTANCE, OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance.

Kongsaeree, P.,Khongsuk, P.,Leartsakulpanich, U. et al.
(2005) Proc.Natl.Acad.Sci.USA 102 : 13046

PDB ID: 2BLA