Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CL Chloride ion
CBO Carbenoxolone
NAP Nadp nicotinamide-adenine-dinucleotide phosphate
Code : 2BEL
Header : OXIDOREDUCTASE
Title : Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone
Release Data : 2004-12-06
Compound :
mol_id molecule chains synonym
1 CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1 A,B,C,D HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1,11-DH, 11-BETA-HSD1
ec: 1.1.1.146
fragment: RESIDUES 26-284
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_plasmid: P11
Authors : Kavanagh, K., Wu, X., Svensson, S., Elleby, B., von Delft, F., Debreczeni, J.E., Sharma, S., Bray, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Abrahmsen, L., Oppermann, U.
Keywords : OXIDOREDUCTASE, GLUCOCORTICOID ACTIVATION, DRUG TARGET, INHIBITOR, SHORT-CHAIN DEHYDROGENASE/REDUCTASE, HORMONE METABOLISM, MICROSOME, NADP, STEROID METABOLISM
Exp. method : X-RAY DIFFRACTION ( 2.11 Å )
Citation :

The High Resolution Structures of Human, Murine and Guinea Pig 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Reveal Critical Differences in Active Site Architecture

Wu, X.,Kavanagh, K.,Svensson, S.  et al.
To be Published 

Chain : A, B, C, D
UniProt : P28845 (DHI1_HUMAN)
Reaction : An 11-beta-hydroxysteroid + NADP(+) = an 11- oxosteroid + NADPH.