ID 2BELA STANDARD; PRT; 283 AA. DT CONVERTED FROM PDB (SEQRES) 2BEL DE CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1 OS HOMO SAPIENS CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.110 CC R-Factor 0.190 FT #SUB 93 96 MET A 134 137 ARG B Protein S 1 FT #SUB 124 127 ASN A 197 200 GLU B Protein B 1 FT #SUB 125 128 LEU A 197 200 GLU B Protein A 8 FT #SUB 125 128 LEU A 201 204 SER B Protein S 1 FT #SUB 126 129 PHE A 145 148 VAL B Protein S 1 FT #SUB 126 129 PHE A 149 152 VAL B Protein S 2 FT #SUB 126 129 PHE A 190 193 PHE B Protein S 6 FT #SUB 126 129 PHE A 194 197 ILE B Protein S 1 FT #SUB 126 129 PHE A 197 200 GLU B Protein A 5 FT #SUB 127 130 HIS A 149 152 VAL B Protein B 1 FT #SUB 128 131 ASP A 149 152 VAL B Protein S 1 FT #SUB 130 133 ILE A 142 145 LEU B Protein S 1 FT #SUB 130 133 ILE A 145 148 VAL B Protein S 1 FT #SUB 130 133 ILE A 149 152 VAL B Protein S 1 FT #SUB 133 136 VAL A 141 144 PHE B Protein S 2 FT #SUB 133 136 VAL A 190 193 PHE B Protein S 1 FT #SUB 134 137 ARG A 93 96 MET B Protein S 1 FT #SUB 134 137 ARG A 138 141 GLU B Protein S 8 FT #SUB 134 137 ARG A 142 145 LEU B Protein S 3 FT #SUB 137 140 MET A 137 140 MET B Protein S 3 FT #SUB 137 140 MET A 141 144 PHE B Protein S 1 FT #SUB 138 141 GLU A 134 137 ARG B Protein S 7 FT #SUB 141 144 PHE A 133 136 VAL B Protein S 1 FT #SUB 141 144 PHE A 182 185 ALA B Protein S 1 FT #SUB 142 145 LEU A 134 137 ARG B Protein S 1 FT #SUB 145 148 VAL A 126 129 PHE B Protein S 1 FT #SUB 149 152 VAL A 126 129 PHE B Protein S 2 FT #SUB 149 152 VAL A 127 130 HIS B Protein S 1 FT #SUB 149 152 VAL A 128 131 ASP B Protein S 1 FT #SUB 173 176 ALA A 189 192 GLY B Protein S 1 FT #SUB 173 176 ALA A 192 195 SER B Protein S 2 FT #SUB 173 176 ALA A 193 196 SER B Protein S 2 FT #SUB 173 176 ALA A 196 199 LYS B Protein B 4 FT #SUB 174 177 TYR A 193 196 SER B Protein B 4 FT #SUB 175 178 PRO A 193 196 SER B Protein B 2 FT #SUB 175 178 PRO A 196 199 LYS B Protein S 2 FT #SUB 175 178 PRO A 197 200 GLU B Protein A 4 FT #SUB 176 179 MET A 197 200 GLU B Protein B 5 FT #SUB 177 180 VAL A 193 196 SER B Protein B 1 FT #SUB 178 181 ALA A 190 193 PHE B Protein A 6 FT #SUB 178 181 ALA A 193 196 SER B Protein A 5 FT #SUB 178 181 ALA A 194 197 ILE B Protein S 1 FT #SUB 181 184 SER A 189 192 GLY B Protein S 1 FT #SUB 182 185 ALA A 141 144 PHE B Protein S 2 FT #SUB 182 185 ALA A 186 189 ALA B Protein A 4 FT #SUB 182 185 ALA A 190 193 PHE B Protein S 1 FT #SUB 185 188 PHE A 185 188 PHE B Protein A 8 FT #SUB 185 188 PHE A 188 191 ASP B Protein S 2 FT #SUB 185 188 PHE A 189 192 GLY B Protein S 8 FT #SUB 186 189 ALA A 182 185 ALA B Protein A 4 FT #SUB 188 191 ASP A 185 188 PHE B Protein S 1 FT #SUB 189 192 GLY A 181 184 SER B Protein B 4 FT #SUB 189 192 GLY A 185 188 PHE B Protein B 6 FT #SUB 190 193 PHE A 126 129 PHE B Protein S 3 FT #SUB 190 193 PHE A 178 181 ALA B Protein A 5 FT #SUB 190 193 PHE A 182 185 ALA B Protein A 2 FT #SUB 192 195 SER A 173 176 ALA B Protein S 1 FT #SUB 193 196 SER A 174 177 TYR B Protein A 4 FT #SUB 193 196 SER A 175 178 PRO B Protein B 1 FT #SUB 193 196 SER A 177 180 VAL B Protein S 2 FT #SUB 193 196 SER A 178 181 ALA B Protein S 4 FT #SUB 194 197 ILE A 178 181 ALA B Protein S 1 FT #SUB 196 199 LYS A 173 176 ALA B Protein S 6 FT #SUB 196 199 LYS A 175 178 PRO B Protein A 3 FT #SUB 197 200 GLU A 124 127 ASN B Protein S 1 FT #SUB 197 200 GLU A 125 128 LEU B Protein S 5 FT #SUB 197 200 GLU A 126 129 PHE B Protein S 5 FT #SUB 197 200 GLU A 175 178 PRO B Protein A 4 FT #SUB 197 200 GLU A 176 179 MET B Protein S 5 FT #SUB 197 200 GLU A 177 180 VAL B Protein S 1 FT #SUB 264 267 LEU A 272 275 ILE B Protein A 2 FT #SUB 125 128 LEU A 98 101 GLN D Protein S 3 FT #SUB 125 128 LEU A 102 105 GLN D Protein S 1 FT #SUB 127 130 HIS A 94 97 THR D Protein S 2 FT #SUB 127 130 HIS A 98 101 GLN D Protein S 2 FT #HET 38 41 GLY A 1 1269 NAP A B 8 FT #HET 39 42 ALA A 1 1269 NAP A B 1 FT #HET 40 43 SER A 1 1269 NAP A A 9 FT #HET 41 44 LYS A 1 1269 NAP A A 8 FT #HET 42 45 GLY A 1 1269 NAP A B 4 FT #HET 42 45 GLY A 3 1271 CL A B 2 FT #HET 43 46 ILE A 1 1269 NAP A A 8 FT #HET 62 65 ALA A 1 1269 NAP A A 7 FT #HET 63 66 ARG A 1 1269 NAP A A 25 FT #HET 64 67 SER A 1 1269 NAP A A 4 FT #HET 88 91 GLY A 1 1269 NAP A B 1 FT #HET 89 92 THR A 1 1269 NAP A A 7 FT #HET 90 93 MET A 1 1269 NAP A A 8 FT #HET 116 119 ASN A 1 1269 NAP A A 11 FT #HET 117 120 HIS A 1 1269 NAP A A 4 FT #HET 118 121 ILE A 1 1269 NAP A A 8 FT #HET 118 121 ILE A 2 1270 CBO A S 3 FT #HET 121 124 THR A 2 1270 CBO A B 1 FT #HET 123 126 LEU A 2 1270 CBO A S 2 FT #HET 144 147 TYR A 1 1269 NAP A S 1 FT #HET 165 168 VAL A 1 1269 NAP A A 6 FT #HET 166 169 SER A 1 1269 NAP A B 3 FT #HET 167 170 SER A 1 1269 NAP A A 5 FT #HET 167 170 SER A 2 1270 CBO A S 4 FT #HET 168 171 LEU A 2 1270 CBO A A 2 FT #HET 169 172 ALA A 2 1270 CBO A B 1 FT #HET 174 177 TYR A 2 1270 CBO A S 6 FT #HET 177 180 VAL A 2 1270 CBO A S 1 FT #HET 180 183 TYR A 1 1269 NAP A S 5 FT #HET 180 183 TYR A 2 1270 CBO A S 13 FT #HET 184 187 LYS A 1 1269 NAP A S 5 FT #HET 212 215 LEU A 1 1269 NAP A A 5 FT #HET 213 216 GLY A 1 1269 NAP A B 4 FT #HET 213 216 GLY A 2 1270 CBO A B 5 FT #HET 214 217 LEU A 1 1269 NAP A A 3 FT #HET 214 217 LEU A 2 1270 CBO A A 4 FT #HET 215 218 ILE A 1 1269 NAP A A 11 FT #HET 217 220 THR A 1 1269 NAP A S 6 FT #HET 217 220 THR A 3 1271 CL A A 2 FT #HET 218 221 GLU A 3 1271 CL A B 1 FT #HET 219 222 THR A 1 1269 NAP A S 5 FT #HET 219 222 THR A 2 1270 CBO A S 2 FT #HET 220 223 ALA A 1 1269 NAP A S 3 FT #HET 223 226 ALA A 2 1270 CBO A S 1 FT #HET 224 227 VAL A 2 1270 CBO A S 2 FT #HET 229 232 HIS A 2 1270 CBO A A 5 FT #HET 230 233 MET A 2 1270 CBO A A 10 FT #HET 235 238 LYS A 3 1271 CL A S 2 FT DISORDER 1 22 FT DISORDER 266 283 CC SEQUENCE 243 AA (ATOM); CC EFRPEMLQGK KVIVTGASKG IGREMAYHLA KMGAHVVVTA RSKETLQKVV SHCLELGAAS CC AHYIAGTMED MTFAEQFVAQ AGKLMGGLDM LILNHITNTS LNLFHDDIHH VRKSMEVNFL CC SYVVLTVAAL PMLKQSNGSI VVVSSLAGKV AYPMVAAYSA SKFALDGFFS SIRKEYSVSR CC VNVSITLCVL GLIDTETAMK AVSGIVHMQA APKEECALEI IKGGALRQEE VYYDSSLWTT CC LLI CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSSHHHHHHSSGRENLYFQGHMEFRPEMLQGKKVIVTGASKGIGREMAYH CC ATOM ----------------------EFRPEMLQGKKVIVTGASKGIGREMAYH CC **************************** CC SEQRES LAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV CC ATOM LAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV CC ************************************************** CC SEQRES AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA CC ATOM AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA CC ************************************************** CC SEQRES ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV CC ATOM ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV CC ************************************************** CC SEQRES SRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQ CC ATOM SRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQ CC ************************************************** CC SEQRES EEVYYDSSLWTTLLIRNPCRKILEFLYSTSYGS CC ATOM EEVYYDSSLWTTLLI------------------ CC *************** SQ SEQUENCE 283 AA; MW; CN; GSSHHHHHHS SGRENLYFQG HMEFRPEMLQ GKKVIVTGAS KGIGREMAYH LAKMGAHVVV TARSKETLQK VVSHCLELGA ASAHYIAGTM EDMTFAEQFV AQAGKLMGGL DMLILNHITN TSLNLFHDDI HHVRKSMEVN FLSYVVLTVA ALPMLKQSNG SIVVVSSLAG KVAYPMVAAY SASKFALDGF FSSIRKEYSV SRVNVSITLC VLGLIDTETA MKAVSGIVHM QAAPKEECAL EIIKGGALRQ EEVYYDSSLW TTLLIRNPCR KILEFLYSTS YGS // ID 2BELB STANDARD; PRT; 283 AA. DT CONVERTED FROM PDB (SEQRES) 2BEL DE CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1 OS HOMO SAPIENS CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.110 CC R-Factor 0.190 FT #SUB 93 96 MET B 134 137 ARG A Protein S 1 FT #SUB 124 127 ASN B 197 200 GLU A Protein B 1 FT #SUB 125 128 LEU B 197 200 GLU A Protein A 5 FT #SUB 126 129 PHE B 145 148 VAL A Protein S 1 FT #SUB 126 129 PHE B 149 152 VAL A Protein S 2 FT #SUB 126 129 PHE B 190 193 PHE A Protein S 3 FT #SUB 126 129 PHE B 197 200 GLU A Protein A 5 FT #SUB 127 130 HIS B 149 152 VAL A Protein B 1 FT #SUB 128 131 ASP B 149 152 VAL A Protein S 1 FT #SUB 133 136 VAL B 141 144 PHE A Protein S 1 FT #SUB 134 137 ARG B 93 96 MET A Protein S 1 FT #SUB 134 137 ARG B 138 141 GLU A Protein S 7 FT #SUB 134 137 ARG B 142 145 LEU A Protein S 1 FT #SUB 137 140 MET B 137 140 MET A Protein S 3 FT #SUB 138 141 GLU B 134 137 ARG A Protein S 8 FT #SUB 141 144 PHE B 133 136 VAL A Protein S 2 FT #SUB 141 144 PHE B 137 140 MET A Protein S 1 FT #SUB 141 144 PHE B 182 185 ALA A Protein S 2 FT #SUB 142 145 LEU B 130 133 ILE A Protein S 1 FT #SUB 142 145 LEU B 134 137 ARG A Protein S 3 FT #SUB 145 148 VAL B 126 129 PHE A Protein S 1 FT #SUB 145 148 VAL B 130 133 ILE A Protein S 1 FT #SUB 149 152 VAL B 126 129 PHE A Protein S 2 FT #SUB 149 152 VAL B 127 130 HIS A Protein S 1 FT #SUB 149 152 VAL B 128 131 ASP A Protein S 1 FT #SUB 149 152 VAL B 130 133 ILE A Protein S 1 FT #SUB 173 176 ALA B 192 195 SER A Protein S 1 FT #SUB 173 176 ALA B 196 199 LYS A Protein A 6 FT #SUB 174 177 TYR B 193 196 SER A Protein B 4 FT #SUB 175 178 PRO B 193 196 SER A Protein B 1 FT #SUB 175 178 PRO B 196 199 LYS A Protein S 3 FT #SUB 175 178 PRO B 197 200 GLU A Protein A 4 FT #SUB 176 179 MET B 197 200 GLU A Protein B 5 FT #SUB 177 180 VAL B 193 196 SER A Protein B 2 FT #SUB 177 180 VAL B 197 200 GLU A Protein B 1 FT #SUB 178 181 ALA B 190 193 PHE A Protein A 5 FT #SUB 178 181 ALA B 193 196 SER A Protein A 4 FT #SUB 178 181 ALA B 194 197 ILE A Protein S 1 FT #SUB 181 184 SER B 189 192 GLY A Protein S 4 FT #SUB 182 185 ALA B 141 144 PHE A Protein S 1 FT #SUB 182 185 ALA B 186 189 ALA A Protein A 4 FT #SUB 182 185 ALA B 190 193 PHE A Protein S 2 FT #SUB 185 188 PHE B 185 188 PHE A Protein A 8 FT #SUB 185 188 PHE B 188 191 ASP A Protein S 1 FT #SUB 185 188 PHE B 189 192 GLY A Protein S 6 FT #SUB 186 189 ALA B 182 185 ALA A Protein A 4 FT #SUB 188 191 ASP B 185 188 PHE A Protein S 2 FT #SUB 189 192 GLY B 173 176 ALA A Protein B 1 FT #SUB 189 192 GLY B 181 184 SER A Protein B 1 FT #SUB 189 192 GLY B 185 188 PHE A Protein B 8 FT #SUB 190 193 PHE B 126 129 PHE A Protein S 6 FT #SUB 190 193 PHE B 133 136 VAL A Protein S 1 FT #SUB 190 193 PHE B 178 181 ALA A Protein A 6 FT #SUB 190 193 PHE B 182 185 ALA A Protein S 1 FT #SUB 192 195 SER B 173 176 ALA A Protein A 2 FT #SUB 193 196 SER B 173 176 ALA A Protein B 2 FT #SUB 193 196 SER B 174 177 TYR A Protein A 4 FT #SUB 193 196 SER B 175 178 PRO A Protein A 2 FT #SUB 193 196 SER B 177 180 VAL A Protein S 1 FT #SUB 193 196 SER B 178 181 ALA A Protein S 5 FT #SUB 194 197 ILE B 126 129 PHE A Protein S 1 FT #SUB 194 197 ILE B 178 181 ALA A Protein S 1 FT #SUB 196 199 LYS B 173 176 ALA A Protein S 4 FT #SUB 196 199 LYS B 175 178 PRO A Protein S 2 FT #SUB 197 200 GLU B 124 127 ASN A Protein S 1 FT #SUB 197 200 GLU B 125 128 LEU A Protein S 8 FT #SUB 197 200 GLU B 126 129 PHE A Protein S 5 FT #SUB 197 200 GLU B 175 178 PRO A Protein A 4 FT #SUB 197 200 GLU B 176 179 MET A Protein S 5 FT #SUB 201 204 SER B 125 128 LEU A Protein S 1 FT #SUB 272 275 ILE B 264 267 LEU A Protein S 2 FT #SUB 157 160 GLN B 131 134 HIS C Protein S 1 FT #SUB 156 159 LYS B 94 97 THR D Protein S 1 FT #SUB 199 202 SER B 105 108 LYS D Protein B 1 FT #SUB 200 203 VAL B 105 108 LYS D Protein B 5 FT #SUB 201 204 SER B 101 104 ALA D Protein B 2 FT #HET 38 41 GLY B 4 1278 NAP B B 11 FT #HET 39 42 ALA B 4 1278 NAP B B 1 FT #HET 40 43 SER B 4 1278 NAP B A 9 FT #HET 41 44 LYS B 4 1278 NAP B A 6 FT #HET 42 45 GLY B 4 1278 NAP B B 4 FT #HET 42 45 GLY B 6 1280 CL B B 2 FT #HET 43 46 ILE B 4 1278 NAP B A 8 FT #HET 45 48 ARG B 6 1280 CL B S 1 FT #HET 62 65 ALA B 4 1278 NAP B A 6 FT #HET 63 66 ARG B 4 1278 NAP B A 27 FT #HET 64 67 SER B 4 1278 NAP B A 3 FT #HET 88 91 GLY B 4 1278 NAP B B 1 FT #HET 89 92 THR B 4 1278 NAP B A 5 FT #HET 90 93 MET B 4 1278 NAP B A 8 FT #HET 116 119 ASN B 4 1278 NAP B A 11 FT #HET 117 120 HIS B 4 1278 NAP B A 4 FT #HET 118 121 ILE B 4 1278 NAP B A 11 FT #HET 118 121 ILE B 5 1279 CBO B S 2 FT #HET 121 124 THR B 5 1279 CBO B B 1 FT #HET 123 126 LEU B 5 1279 CBO B S 1 FT #HET 144 147 TYR B 4 1278 NAP B S 1 FT #HET 165 168 VAL B 4 1278 NAP B A 5 FT #HET 166 169 SER B 4 1278 NAP B B 5 FT #HET 167 170 SER B 4 1278 NAP B A 5 FT #HET 167 170 SER B 5 1279 CBO B S 3 FT #HET 168 171 LEU B 5 1279 CBO B A 2 FT #HET 169 172 ALA B 5 1279 CBO B B 1 FT #HET 174 177 TYR B 5 1279 CBO B S 6 FT #HET 177 180 VAL B 5 1279 CBO B S 1 FT #HET 180 183 TYR B 4 1278 NAP B S 4 FT #HET 180 183 TYR B 5 1279 CBO B S 10 FT #HET 184 187 LYS B 4 1278 NAP B S 5 FT #HET 212 215 LEU B 4 1278 NAP B A 2 FT #HET 212 215 LEU B 5 1279 CBO B B 1 FT #HET 213 216 GLY B 4 1278 NAP B B 3 FT #HET 213 216 GLY B 5 1279 CBO B B 5 FT #HET 214 217 LEU B 4 1278 NAP B A 3 FT #HET 214 217 LEU B 5 1279 CBO B A 5 FT #HET 215 218 ILE B 4 1278 NAP B A 12 FT #HET 217 220 THR B 4 1278 NAP B S 6 FT #HET 217 220 THR B 6 1280 CL B A 2 FT #HET 218 221 GLU B 6 1280 CL B B 1 FT #HET 219 222 THR B 4 1278 NAP B S 6 FT #HET 219 222 THR B 5 1279 CBO B S 2 FT #HET 220 223 ALA B 4 1278 NAP B S 3 FT #HET 223 226 ALA B 5 1279 CBO B S 1 FT #HET 224 227 VAL B 5 1279 CBO B S 1 FT #HET 235 238 LYS B 6 1280 CL B S 1 FT DISORDER 1 23 FT DISORDER 275 283 CC SEQUENCE 251 AA (ATOM); CC FRPEMLQGKK VIVTGASKGI GREMAYHLAK MGAHVVVTAR SKETLQKVVS HCLELGAASA CC HYIAGTMEDM TFAEQFVAQA GKLMGGLDML ILNHITNTSL NLFHDDIHHV RKSMEVNFLS CC YVVLTVAALP MLKQSNGSIV VVSSLAGKVA YPMVAAYSAS KFALDGFFSS IRKEYSVSRV CC NVSITLCVLG LIDTETAMKA VSGIVHMQAA PKEECALEII KGGALRQEEV YYDSSLWTTL CC LIRNPCRKIL E CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSSHHHHHHSSGRENLYFQGHMEFRPEMLQGKKVIVTGASKGIGREMAYH CC ATOM -----------------------FRPEMLQGKKVIVTGASKGIGREMAYH CC *************************** CC SEQRES LAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV CC ATOM LAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV CC ************************************************** CC SEQRES AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA CC ATOM AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA CC ************************************************** CC SEQRES ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV CC ATOM ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV CC ************************************************** CC SEQRES SRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQ CC ATOM SRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQ CC ************************************************** CC SEQRES EEVYYDSSLWTTLLIRNPCRKILEFLYSTSYGS CC ATOM EEVYYDSSLWTTLLIRNPCRKILE--------- CC ************************ SQ SEQUENCE 283 AA; MW; CN; GSSHHHHHHS SGRENLYFQG HMEFRPEMLQ GKKVIVTGAS KGIGREMAYH LAKMGAHVVV TARSKETLQK VVSHCLELGA ASAHYIAGTM EDMTFAEQFV AQAGKLMGGL DMLILNHITN TSLNLFHDDI HHVRKSMEVN FLSYVVLTVA ALPMLKQSNG SIVVVSSLAG KVAYPMVAAY SASKFALDGF FSSIRKEYSV SRVNVSITLC VLGLIDTETA MKAVSGIVHM QAAPKEECAL EIIKGGALRQ EEVYYDSSLW TTLLIRNPCR KILEFLYSTS YGS // ID 2BELC STANDARD; PRT; 283 AA. DT CONVERTED FROM PDB (SEQRES) 2BEL DE CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1 OS HOMO SAPIENS CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.110 CC R-Factor 0.190 FT #SUB 131 134 HIS C 157 160 GLN B Protein S 1 FT #SUB 93 96 MET C 134 137 ARG D Protein S 1 FT #SUB 124 127 ASN C 197 200 GLU D Protein B 1 FT #SUB 125 128 LEU C 197 200 GLU D Protein A 8 FT #SUB 126 129 PHE C 145 148 VAL D Protein S 1 FT #SUB 126 129 PHE C 149 152 VAL D Protein S 2 FT #SUB 126 129 PHE C 190 193 PHE D Protein S 6 FT #SUB 126 129 PHE C 197 200 GLU D Protein A 5 FT #SUB 127 130 HIS C 149 152 VAL D Protein B 1 FT #SUB 128 131 ASP C 149 152 VAL D Protein S 1 FT #SUB 133 136 VAL C 141 144 PHE D Protein S 1 FT #SUB 134 137 ARG C 93 96 MET D Protein S 1 FT #SUB 134 137 ARG C 138 141 GLU D Protein S 8 FT #SUB 134 137 ARG C 142 145 LEU D Protein S 5 FT #SUB 137 140 MET C 137 140 MET D Protein S 2 FT #SUB 137 140 MET C 141 144 PHE D Protein S 1 FT #SUB 138 141 GLU C 134 137 ARG D Protein S 2 FT #SUB 141 144 PHE C 133 136 VAL D Protein S 2 FT #SUB 141 144 PHE C 137 140 MET D Protein S 1 FT #SUB 141 144 PHE C 182 185 ALA D Protein S 1 FT #SUB 142 145 LEU C 133 136 VAL D Protein S 1 FT #SUB 142 145 LEU C 134 137 ARG D Protein S 3 FT #SUB 145 148 VAL C 126 129 PHE D Protein S 1 FT #SUB 149 152 VAL C 126 129 PHE D Protein S 2 FT #SUB 149 152 VAL C 127 130 HIS D Protein S 1 FT #SUB 149 152 VAL C 128 131 ASP D Protein S 1 FT #SUB 171 174 LYS C 271 274 LYS D Protein S 1 FT #SUB 173 176 ALA C 192 195 SER D Protein S 3 FT #SUB 173 176 ALA C 196 199 LYS D Protein A 2 FT #SUB 174 177 TYR C 193 196 SER D Protein B 4 FT #SUB 175 178 PRO C 193 196 SER D Protein B 1 FT #SUB 175 178 PRO C 196 199 LYS D Protein A 3 FT #SUB 175 178 PRO C 197 200 GLU D Protein A 2 FT #SUB 176 179 MET C 197 200 GLU D Protein B 5 FT #SUB 177 180 VAL C 193 196 SER D Protein B 2 FT #SUB 177 180 VAL C 197 200 GLU D Protein B 1 FT #SUB 178 181 ALA C 190 193 PHE D Protein A 5 FT #SUB 178 181 ALA C 193 196 SER D Protein A 5 FT #SUB 178 181 ALA C 194 197 ILE D Protein S 1 FT #SUB 179 182 ALA C 190 193 PHE D Protein B 1 FT #SUB 181 184 SER C 189 192 GLY D Protein S 1 FT #SUB 182 185 ALA C 141 144 PHE D Protein S 2 FT #SUB 182 185 ALA C 186 189 ALA D Protein A 4 FT #SUB 182 185 ALA C 190 193 PHE D Protein S 1 FT #SUB 185 188 PHE C 185 188 PHE D Protein A 8 FT #SUB 185 188 PHE C 188 191 ASP D Protein S 1 FT #SUB 185 188 PHE C 189 192 GLY D Protein S 7 FT #SUB 186 189 ALA C 182 185 ALA D Protein A 4 FT #SUB 188 191 ASP C 185 188 PHE D Protein S 1 FT #SUB 189 192 GLY C 181 184 SER D Protein B 1 FT #SUB 189 192 GLY C 185 188 PHE D Protein B 6 FT #SUB 190 193 PHE C 126 129 PHE D Protein S 3 FT #SUB 190 193 PHE C 178 181 ALA D Protein A 5 FT #SUB 190 193 PHE C 182 185 ALA D Protein S 1 FT #SUB 192 195 SER C 173 176 ALA D Protein A 3 FT #SUB 193 196 SER C 174 177 TYR D Protein A 5 FT #SUB 193 196 SER C 175 178 PRO D Protein A 2 FT #SUB 193 196 SER C 177 180 VAL D Protein S 4 FT #SUB 193 196 SER C 178 181 ALA D Protein S 4 FT #SUB 194 197 ILE C 126 129 PHE D Protein S 1 FT #SUB 194 197 ILE C 178 181 ALA D Protein S 1 FT #SUB 196 199 LYS C 173 176 ALA D Protein S 1 FT #SUB 196 199 LYS C 174 177 TYR D Protein S 1 FT #SUB 196 199 LYS C 175 178 PRO D Protein S 6 FT #SUB 197 200 GLU C 124 127 ASN D Protein S 1 FT #SUB 197 200 GLU C 125 128 LEU D Protein S 9 FT #SUB 197 200 GLU C 126 129 PHE D Protein S 5 FT #SUB 197 200 GLU C 175 178 PRO D Protein A 4 FT #SUB 197 200 GLU C 176 179 MET D Protein S 5 FT #SUB 197 200 GLU C 177 180 VAL D Protein S 1 FT #SUB 252 255 GLU C 271 274 LYS D Protein S 2 FT #SUB 264 267 LEU C 271 274 LYS D Protein S 3 FT #SUB 264 267 LEU C 272 275 ILE D Protein B 2 FT #HET 38 41 GLY C 7 1272 NAP C B 8 FT #HET 39 42 ALA C 7 1272 NAP C B 1 FT #HET 40 43 SER C 7 1272 NAP C A 9 FT #HET 41 44 LYS C 7 1272 NAP C A 9 FT #HET 42 45 GLY C 7 1272 NAP C B 4 FT #HET 42 45 GLY C 9 1274 CL C B 2 FT #HET 43 46 ILE C 7 1272 NAP C A 9 FT #HET 62 65 ALA C 7 1272 NAP C S 2 FT #HET 63 66 ARG C 7 1272 NAP C A 26 FT #HET 64 67 SER C 7 1272 NAP C A 3 FT #HET 88 91 GLY C 7 1272 NAP C B 2 FT #HET 89 92 THR C 7 1272 NAP C A 5 FT #HET 90 93 MET C 7 1272 NAP C A 7 FT #HET 116 119 ASN C 7 1272 NAP C A 11 FT #HET 117 120 HIS C 7 1272 NAP C A 4 FT #HET 118 121 ILE C 7 1272 NAP C A 11 FT #HET 118 121 ILE C 8 1273 CBO C S 2 FT #HET 121 124 THR C 8 1273 CBO C A 2 FT #HET 144 147 TYR C 7 1272 NAP C S 1 FT #HET 165 168 VAL C 7 1272 NAP C A 4 FT #HET 166 169 SER C 7 1272 NAP C B 5 FT #HET 167 170 SER C 7 1272 NAP C A 5 FT #HET 167 170 SER C 8 1273 CBO C S 4 FT #HET 168 171 LEU C 8 1273 CBO C A 3 FT #HET 169 172 ALA C 8 1273 CBO C B 1 FT #HET 174 177 TYR C 8 1273 CBO C S 4 FT #HET 177 180 VAL C 8 1273 CBO C S 2 FT #HET 180 183 TYR C 7 1272 NAP C S 5 FT #HET 180 183 TYR C 8 1273 CBO C S 11 FT #HET 184 187 LYS C 7 1272 NAP C S 3 FT #HET 212 215 LEU C 7 1272 NAP C A 4 FT #HET 212 215 LEU C 8 1273 CBO C B 1 FT #HET 213 216 GLY C 7 1272 NAP C B 4 FT #HET 213 216 GLY C 8 1273 CBO C B 4 FT #HET 214 217 LEU C 7 1272 NAP C A 3 FT #HET 214 217 LEU C 8 1273 CBO C A 4 FT #HET 215 218 ILE C 7 1272 NAP C A 12 FT #HET 217 220 THR C 7 1272 NAP C S 8 FT #HET 217 220 THR C 9 1274 CL C A 2 FT #HET 218 221 GLU C 9 1274 CL C B 1 FT #HET 219 222 THR C 7 1272 NAP C S 5 FT #HET 219 222 THR C 8 1273 CBO C S 2 FT #HET 220 223 ALA C 7 1272 NAP C S 3 FT #HET 223 226 ALA C 8 1273 CBO C S 1 FT #HET 224 227 VAL C 8 1273 CBO C S 2 FT #HET 235 238 LYS C 9 1274 CL C S 1 FT DISORDER 1 11 FT DISORDER 227 229 FT DISORDER 269 283 CC SEQUENCE 254 AA (ATOM); CC GRENLYFQGH MEFRPEMLQG KKVIVTGASK GIGREMAYHL AKMGAHVVVT ARSKETLQKV CC VSHCLELGAA SAHYIAGTME DMTFAEQFVA QAGKLMGGLD MLILNHITNT SLNLFHDDIH CC HVRKSMEVNF LSYVVLTVAA LPMLKQSNGS IVVVSSLAGK VAYPMVAAYS ASKFALDGFF CC SSIRKEYSVS RVNVSITLCV LGLIDTETAM KAVSGMQAAP KEECALEIIK GGALRQEEVY CC YDSSLWTTLL IRNP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSSHHHHHHSSGRENLYFQGHMEFRPEMLQGKKVIVTGASKGIGREMAYH CC ATOM -----------GRENLYFQGHMEFRPEMLQGKKVIVTGASKGIGREMAYH CC *************************************** CC SEQRES LAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV CC ATOM LAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV CC ************************************************** CC SEQRES AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA CC ATOM AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA CC ************************************************** CC SEQRES ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV CC ATOM ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV CC ************************************************** CC SEQRES SRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQ CC ATOM SRVNVSITLCVLGLIDTETAMKAVSG---MQAAPKEECALEIIKGGALRQ CC ************************** ********************* CC SEQRES EEVYYDSSLWTTLLIRNPCRKILEFLYSTSYGS CC ATOM EEVYYDSSLWTTLLIRNP--------------- CC ****************** SQ SEQUENCE 283 AA; MW; CN; GSSHHHHHHS SGRENLYFQG HMEFRPEMLQ GKKVIVTGAS KGIGREMAYH LAKMGAHVVV TARSKETLQK VVSHCLELGA ASAHYIAGTM EDMTFAEQFV AQAGKLMGGL DMLILNHITN TSLNLFHDDI HHVRKSMEVN FLSYVVLTVA ALPMLKQSNG SIVVVSSLAG KVAYPMVAAY SASKFALDGF FSSIRKEYSV SRVNVSITLC VLGLIDTETA MKAVSGIVHM QAAPKEECAL EIIKGGALRQ EEVYYDSSLW TTLLIRNPCR KILEFLYSTS YGS // ID 2BELD STANDARD; PRT; 283 AA. DT CONVERTED FROM PDB (SEQRES) 2BEL DE CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1 OS HOMO SAPIENS CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.110 CC R-Factor 0.190 FT #SUB 94 97 THR D 127 130 HIS A Protein S 2 FT #SUB 98 101 GLN D 125 128 LEU A Protein S 3 FT #SUB 98 101 GLN D 127 130 HIS A Protein S 2 FT #SUB 102 105 GLN D 125 128 LEU A Protein S 1 FT #SUB 94 97 THR D 156 159 LYS B Protein S 1 FT #SUB 101 104 ALA D 201 204 SER B Protein S 2 FT #SUB 105 108 LYS D 199 202 SER B Protein S 1 FT #SUB 105 108 LYS D 200 203 VAL B Protein S 5 FT #SUB 93 96 MET D 134 137 ARG C Protein S 1 FT #SUB 124 127 ASN D 197 200 GLU C Protein B 1 FT #SUB 125 128 LEU D 197 200 GLU C Protein A 9 FT #SUB 126 129 PHE D 145 148 VAL C Protein S 1 FT #SUB 126 129 PHE D 149 152 VAL C Protein S 2 FT #SUB 126 129 PHE D 190 193 PHE C Protein S 3 FT #SUB 126 129 PHE D 194 197 ILE C Protein S 1 FT #SUB 126 129 PHE D 197 200 GLU C Protein A 5 FT #SUB 127 130 HIS D 149 152 VAL C Protein B 1 FT #SUB 128 131 ASP D 149 152 VAL C Protein S 1 FT #SUB 133 136 VAL D 141 144 PHE C Protein S 2 FT #SUB 133 136 VAL D 142 145 LEU C Protein S 1 FT #SUB 134 137 ARG D 93 96 MET C Protein S 1 FT #SUB 134 137 ARG D 138 141 GLU C Protein S 2 FT #SUB 134 137 ARG D 142 145 LEU C Protein S 3 FT #SUB 137 140 MET D 137 140 MET C Protein S 2 FT #SUB 137 140 MET D 141 144 PHE C Protein S 1 FT #SUB 138 141 GLU D 134 137 ARG C Protein S 8 FT #SUB 141 144 PHE D 133 136 VAL C Protein S 1 FT #SUB 141 144 PHE D 137 140 MET C Protein S 1 FT #SUB 141 144 PHE D 182 185 ALA C Protein S 2 FT #SUB 142 145 LEU D 134 137 ARG C Protein S 5 FT #SUB 145 148 VAL D 126 129 PHE C Protein S 1 FT #SUB 149 152 VAL D 126 129 PHE C Protein S 2 FT #SUB 149 152 VAL D 127 130 HIS C Protein S 1 FT #SUB 149 152 VAL D 128 131 ASP C Protein S 1 FT #SUB 173 176 ALA D 192 195 SER C Protein S 3 FT #SUB 173 176 ALA D 196 199 LYS C Protein B 1 FT #SUB 174 177 TYR D 193 196 SER C Protein B 5 FT #SUB 174 177 TYR D 196 199 LYS C Protein B 1 FT #SUB 175 178 PRO D 193 196 SER C Protein B 2 FT #SUB 175 178 PRO D 196 199 LYS C Protein A 6 FT #SUB 175 178 PRO D 197 200 GLU C Protein A 4 FT #SUB 176 179 MET D 197 200 GLU C Protein B 5 FT #SUB 177 180 VAL D 193 196 SER C Protein A 4 FT #SUB 177 180 VAL D 197 200 GLU C Protein B 1 FT #SUB 178 181 ALA D 190 193 PHE C Protein A 5 FT #SUB 178 181 ALA D 193 196 SER C Protein A 4 FT #SUB 178 181 ALA D 194 197 ILE C Protein S 1 FT #SUB 181 184 SER D 189 192 GLY C Protein S 1 FT #SUB 182 185 ALA D 141 144 PHE C Protein S 1 FT #SUB 182 185 ALA D 186 189 ALA C Protein A 4 FT #SUB 182 185 ALA D 190 193 PHE C Protein S 1 FT #SUB 185 188 PHE D 185 188 PHE C Protein A 8 FT #SUB 185 188 PHE D 188 191 ASP C Protein S 1 FT #SUB 185 188 PHE D 189 192 GLY C Protein S 6 FT #SUB 186 189 ALA D 182 185 ALA C Protein A 4 FT #SUB 188 191 ASP D 185 188 PHE C Protein S 1 FT #SUB 189 192 GLY D 181 184 SER C Protein B 1 FT #SUB 189 192 GLY D 185 188 PHE C Protein B 7 FT #SUB 190 193 PHE D 126 129 PHE C Protein S 6 FT #SUB 190 193 PHE D 178 181 ALA C Protein A 5 FT #SUB 190 193 PHE D 179 182 ALA C Protein S 1 FT #SUB 190 193 PHE D 182 185 ALA C Protein S 1 FT #SUB 192 195 SER D 173 176 ALA C Protein A 3 FT #SUB 193 196 SER D 174 177 TYR C Protein A 4 FT #SUB 193 196 SER D 175 178 PRO C Protein S 1 FT #SUB 193 196 SER D 177 180 VAL C Protein S 2 FT #SUB 193 196 SER D 178 181 ALA C Protein S 5 FT #SUB 194 197 ILE D 178 181 ALA C Protein S 1 FT #SUB 196 199 LYS D 173 176 ALA C Protein S 2 FT #SUB 196 199 LYS D 175 178 PRO C Protein S 3 FT #SUB 197 200 GLU D 124 127 ASN C Protein S 1 FT #SUB 197 200 GLU D 125 128 LEU C Protein S 8 FT #SUB 197 200 GLU D 126 129 PHE C Protein S 5 FT #SUB 197 200 GLU D 175 178 PRO C Protein S 2 FT #SUB 197 200 GLU D 176 179 MET C Protein S 5 FT #SUB 197 200 GLU D 177 180 VAL C Protein S 1 FT #SUB 271 274 LYS D 171 174 LYS C Protein S 1 FT #SUB 271 274 LYS D 252 255 GLU C Protein S 2 FT #SUB 271 274 LYS D 264 267 LEU C Protein A 3 FT #SUB 272 275 ILE D 264 267 LEU C Protein S 2 FT #HET 38 41 GLY D 10 1278 NAP D B 10 FT #HET 39 42 ALA D 10 1278 NAP D B 1 FT #HET 40 43 SER D 10 1278 NAP D A 10 FT #HET 41 44 LYS D 10 1278 NAP D A 6 FT #HET 42 45 GLY D 10 1278 NAP D B 4 FT #HET 42 45 GLY D 12 1280 CL D B 2 FT #HET 43 46 ILE D 10 1278 NAP D A 6 FT #HET 45 48 ARG D 12 1280 CL D S 1 FT #HET 62 65 ALA D 10 1278 NAP D A 7 FT #HET 63 66 ARG D 10 1278 NAP D A 29 FT #HET 64 67 SER D 10 1278 NAP D A 5 FT #HET 88 91 GLY D 10 1278 NAP D B 1 FT #HET 89 92 THR D 10 1278 NAP D A 5 FT #HET 90 93 MET D 10 1278 NAP D A 7 FT #HET 116 119 ASN D 10 1278 NAP D A 11 FT #HET 117 120 HIS D 10 1278 NAP D A 3 FT #HET 118 121 ILE D 10 1278 NAP D A 10 FT #HET 118 121 ILE D 11 1279 CBO D S 2 FT #HET 121 124 THR D 11 1279 CBO D A 4 FT #HET 144 147 TYR D 10 1278 NAP D S 1 FT #HET 165 168 VAL D 10 1278 NAP D A 4 FT #HET 166 169 SER D 10 1278 NAP D B 4 FT #HET 167 170 SER D 10 1278 NAP D A 4 FT #HET 167 170 SER D 11 1279 CBO D S 4 FT #HET 168 171 LEU D 11 1279 CBO D S 1 FT #HET 169 172 ALA D 11 1279 CBO D A 2 FT #HET 174 177 TYR D 11 1279 CBO D S 6 FT #HET 177 180 VAL D 11 1279 CBO D S 2 FT #HET 180 183 TYR D 10 1278 NAP D S 5 FT #HET 180 183 TYR D 11 1279 CBO D S 10 FT #HET 184 187 LYS D 10 1278 NAP D S 3 FT #HET 212 215 LEU D 10 1278 NAP D A 5 FT #HET 212 215 LEU D 11 1279 CBO D B 1 FT #HET 213 216 GLY D 10 1278 NAP D B 4 FT #HET 213 216 GLY D 11 1279 CBO D B 4 FT #HET 214 217 LEU D 10 1278 NAP D A 3 FT #HET 214 217 LEU D 11 1279 CBO D A 5 FT #HET 215 218 ILE D 10 1278 NAP D A 12 FT #HET 217 220 THR D 10 1278 NAP D S 7 FT #HET 217 220 THR D 12 1280 CL D A 2 FT #HET 218 221 GLU D 12 1280 CL D B 1 FT #HET 219 222 THR D 10 1278 NAP D S 5 FT #HET 219 222 THR D 11 1279 CBO D S 1 FT #HET 220 223 ALA D 10 1278 NAP D S 3 FT #HET 223 226 ALA D 11 1279 CBO D S 1 FT #HET 224 227 VAL D 11 1279 CBO D S 2 FT #HET 230 233 MET D 11 1279 CBO D S 2 FT #HET 235 238 LYS D 12 1280 CL D S 1 FT DISORDER 1 21 FT DISORDER 275 283 CC SEQUENCE 253 AA (ATOM); CC MEFRPEMLQG KKVIVTGASK GIGREMAYHL AKMGAHVVVT ARSKETLQKV VSHCLELGAA CC SAHYIAGTME DMTFAEQFVA QAGKLMGGLD MLILNHITNT SLNLFHDDIH HVRKSMEVNF CC LSYVVLTVAA LPMLKQSNGS IVVVSSLAGK VAYPMVAAYS ASKFALDGFF SSIRKEYSVS CC RVNVSITLCV LGLIDTETAM KAVSGIVHMQ AAPKEECALE IIKGGALRQE EVYYDSSLWT CC TLLIRNPCRK ILE CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSSHHHHHHSSGRENLYFQGHMEFRPEMLQGKKVIVTGASKGIGREMAYH CC ATOM ---------------------MEFRPEMLQGKKVIVTGASKGIGREMAYH CC ***************************** CC SEQRES LAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV CC ATOM LAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFV CC ************************************************** CC SEQRES AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA CC ATOM AQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA CC ************************************************** CC SEQRES ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV CC ATOM ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV CC ************************************************** CC SEQRES SRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQ CC ATOM SRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQ CC ************************************************** CC SEQRES EEVYYDSSLWTTLLIRNPCRKILEFLYSTSYGS CC ATOM EEVYYDSSLWTTLLIRNPCRKILE--------- CC ************************ SQ SEQUENCE 283 AA; MW; CN; GSSHHHHHHS SGRENLYFQG HMEFRPEMLQ GKKVIVTGAS KGIGREMAYH LAKMGAHVVV TARSKETLQK VVSHCLELGA ASAHYIAGTM EDMTFAEQFV AQAGKLMGGL DMLILNHITN TSLNLFHDDI HHVRKSMEVN FLSYVVLTVA ALPMLKQSNG SIVVVSSLAG KVAYPMVAAY SASKFALDGF FSSIRKEYSV SRVNVSITLC VLGLIDTETA MKAVSGIVHM QAAPKEECAL EIIKGGALRQ EEVYYDSSLW TTLLIRNPCR KILEFLYSTS YGS //