Brand  (β version)

PDB ID: 2AXN

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Ligands
Code Name Style Show Link
ADP Adenosine-5'-diphosphate PoSSuM
EDT {[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid PoSSuM
F6P 6-O-phosphono-beta-D-fructofuranose PoSSuM
Non-standard Residues
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Structure summary

Code : 2AXN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE, HYDROLASE
Title : Crystal structure of the human inducible form 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Release Data : 2005-12-06
Compound :
mol_id molecule chains
1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PFKFB3
Authors : Kim, S.G., Manes, N.P., El-Maghrabi, M.R., Lee, Y.H.
Keywords : bifunctional enzyme, EDTA complex, TRANSFERASE, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy.

Kim, S.G.,Manes, N.P.,El-Maghrabi, M.R.  et al.
(2006)  J.Biol.Chem.  281 : 2939 - 2944

PubMed: 16316985
DOI: 10.1074/jbc.M511019200

Reaction

Chain : A
UniProt : Q16875 (F263_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate 3.1.3.46 PubMed:16316985, PubMed:17499765, PubMed:22275052
left-to-right PubMed:16316985
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6- bisphosphate + H(+) 2.7.1.105 PubMed:10077634, PubMed:17499765, PubMed:16316985
left-to-right PubMed:10077634