ID	2AXNA	STANDARD;	PRT;	520	AA.
DT	CONVERTED FROM PDB (SEQRES) 2AXN
DE	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2A
DE	SE brain/placenta-type isozyme) (iPFK-2) [Includes: 6- phosphofructo-2-kina
DE	se (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.100
CC	R-Factor	0.209
FT	#HET	43	  42 	LEU	A	3	738 	ADP	A	B	1
FT	#HET	44	  43 	PRO	A	2	737 	EDT	A	A	4
FT	#HET	44	  43 	PRO	A	3	738 	ADP	A	B	2
FT	#HET	45	  44 	ALA	A	3	738 	ADP	A	B	10
FT	#HET	46	  45 	ARG	A	3	738 	ADP	A	B	13
FT	#HET	47	  46 	GLY	A	3	738 	ADP	A	B	19
FT	#HET	48	  47 	LYS	A	2	737 	EDT	A	S	3
FT	#HET	48	  47 	LYS	A	3	738 	ADP	A	A	16
FT	#HET	49	  48 	THR	A	2	737 	EDT	A	S	1
FT	#HET	49	  48 	THR	A	3	738 	ADP	A	A	9
FT	#HET	50	  49 	TYR	A	3	738 	ADP	A	A	9
FT	#HET	70	  69 	ASN	A	2	737 	EDT	A	S	10
FT	#HET	72	  71 	GLY	A	2	737 	EDT	A	B	9
FT	#HET	75	  74 	ARG	A	2	737 	EDT	A	S	12
FT	#HET	76	  75 	ARG	A	2	737 	EDT	A	S	8
FT	#HET	88	  87 	PHE	A	2	737 	EDT	A	S	6
FT	#HET	99	  98 	ARG	A	2	737 	EDT	A	S	1
FT	#HET	125	 124 	ASP	A	2	737 	EDT	A	B	1
FT	#HET	126	 125 	ALA	A	2	737 	EDT	A	A	4
FT	#HET	127	 126 	THR	A	2	737 	EDT	A	A	13
FT	#HET	153	 152 	SER	A	3	738 	ADP	A	S	3
FT	#HET	160	 159 	VAL	A	3	738 	ADP	A	S	2
FT	#HET	164	 163 	ASN	A	3	738 	ADP	A	A	16
FT	#HET	167	 166 	GLU	A	3	738 	ADP	A	S	5
FT	#HET	168	 167 	VAL	A	3	738 	ADP	A	S	3
FT	#HET	169	 168 	LYS	A	3	738 	ADP	A	S	8
FT	#HET	190	 189 	ARG	A	2	737 	EDT	A	S	1
FT	#HET	194	 193 	TYR	A	2	737 	EDT	A	S	5
FT	#HET	215	 214 	VAL	A	3	738 	ADP	A	S	1
FT	#HET	218	 217 	VAL	A	3	738 	ADP	A	A	5
FT	#HET	244	 243 	VAL	A	3	738 	ADP	A	S	4
FT	#HET	253	 252 	ARG	A	1	736 	F6P	A	S	1
FT	#HET	260	 259 	ASN	A	1	736 	F6P	A	S	1
FT	#HET	265	 264 	ILE	A	1	736 	F6P	A	A	7
FT	#HET	266	 265 	GLY	A	1	736 	F6P	A	B	4
FT	#HET	323	 322 	GLU	A	1	736 	F6P	A	S	9
FT	#HET	334	 333 	TYR	A	1	736 	F6P	A	S	7
FT	#HET	348	 347 	ARG	A	1	736 	F6P	A	S	8
FT	#HET	352	 351 	LYS	A	1	736 	F6P	A	S	6
FT	#HET	363	 362 	TYR	A	1	736 	F6P	A	S	4
FT	#HET	389	 388 	GLN	A	1	736 	F6P	A	S	6
FT	#HET	393	 392 	ARG	A	1	736 	F6P	A	S	5
FT	#HET	425	 424 	TYR	A	3	738 	ADP	A	S	8
FT	#HET	441	 440 	THR	A	1	736 	F6P	A	S	3
FT	DISORDER	1	2
FT	DISORDER	30	32
FT	DISORDER	447	453
FT	DISORDER	462	515
FT	DISORDER	518	520
CC	SEQUENCE	451 AA (ATOM);
CC	LELTQSRVQK IWVPVDHRPS LPRSCGPNSP TVIVMVGLPA RGKTYISKKL TRYLNWIGVP
CC	TKVFNVGEYR REAVKQYSSY NFFRPDNEEA MKVRKQCALA ALRDVKSYLA KEGGQIAVFD
CC	ATNTTRERRH MILHFAKEND FKAFFIESVC DDPTVVASNI MEVKISSPDY KDCNSAEAMD
CC	DFMKRISCYE ASYQPLDPDK CDRDLSLIKV IDVGRRFLVN RVQDHIQSRI VYYLMNIHVQ
CC	PRTIYLCRHG ENEHNLQGRI GGDSGLSSRG KKFASALSKF VEEQNLKDLR VWTSQLKSTI
CC	QTAEALRLPY EQWKALNEID AGVCEELTYE EIRDTYPEEY ALREQDKYYY RYPTGESYQD
CC	LVQRLEPVIM ELERQENVLV ICHQAVLRCL LAYFLDKSAE EMPYLKCPLH TVLKLTPVAY
CC	GCRVESIYLN VESVCTHRER SNPLMRRNSS S
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTY
CC	ATOM   --LELTQSRVQKIWVPVDHRPSLPRSCGP---NSPTVIVMVGLPARGKTY
CC	         ***************************   ******************
CC	SEQRES ISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRK
CC	ATOM   ISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRK
CC	       **************************************************
CC	SEQRES QCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFF
CC	ATOM   QCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFF
CC	       **************************************************
CC	SEQRES IESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQP
CC	ATOM   IESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQP
CC	       **************************************************
CC	SEQRES LDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIY
CC	ATOM   LDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIY
CC	       **************************************************
CC	SEQRES LCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
CC	ATOM   LCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
CC	       **************************************************
CC	SEQRES LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQ
CC	ATOM   LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQ
CC	       **************************************************
CC	SEQRES DKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFL
CC	ATOM   DKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFL
CC	       **************************************************
CC	SEQRES DKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSEDAK
CC	ATOM   DKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERS----
CC	       **********************************************    
CC	SEQRES KGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPT
CC	ATOM   ---NPLMRRNS---------------------------------------
CC	          ********                                       
CC	SEQRES QLPGQNMKGSRSSADSSRKH
CC	ATOM   ---------------SS---
CC	                      **   
SQ	SEQUENCE	520 AA;      MW;         CN;
	MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY ISKKLTRYLN
	WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMKVRK QCALAALRDV KSYLAKEGGQ
	IAVFDATNTT RERRHMILHF AKENDFKAFF IESVCDDPTV VASNIMEVKI SSPDYKDCNS
	AEAMDDFMKR ISCYEASYQP LDPDKCDRDL SLIKVIDVGR RFLVNRVQDH IQSRIVYYLM
	NIHVQPRTIY LCRHGENEHN LQGRIGGDSG LSSRGKKFAS ALSKFVEEQN LKDLRVWTSQ
	LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ DKYYYRYPTG
	ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL DKSAEEMPYL KCPLHTVLKL
	TPVAYGCRVE SIYLNVESVC THRERSEDAK KGPNPLMRRN SVTPLASPEP TKKPRINSFE
	EHVASTSAAL PSCLPPEVPT QLPGQNMKGS RSSADSSRKH
//