Brand  (β version)

PDB ID: 1YJW

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CD Cadmium ion PoSSuM
CL Chloride ion PoSSuM
K Potassium ion PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
004 (2s)-amino(phenyl)ethanoic acid
1MA 6-hydro-1-methyladenosine-5'-monophosphate
DBB D-alpha-aminobutyric acid
MHU 4-N,N-(dimethylamino)-L-phenylalanine
MHV 4-oxo-L-pipecolic acid
MHW 3-hydroxypicolinic acid
OMG O2'-methylguanosine-5'-monophosphate
OMU O2'-methyluridine 5'-monophosphate
PSU Pseudouridine-5'-monophosphate
UR3 3-methyluridine-5'-monophoshate
Glycosylation
Code Name Emphasize
Modification
Code Name Show
MHT (3s)-3-(methylsulfanyl)-1-azabicyclo[2.2.2]octane

Structure summary

Code : 1YJW   PDBj   RCSB PDB   PDBe
Header : RIBOSOME/ANTIBIOTIC
Title : Crystal Structure Of Quinupristin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui
Release Data : 2005-04-26
Compound :
mol_id molecule chains
1 23S RIBOSOMAL RNA 0
mutation: YES
other_details: ENCODED BY RRNA OPERON
mol_id molecule chains synonym
2 50S ribosomal protein L37e 1 L35e
mol_id molecule chains synonym
3 50S ribosomal protein L39e 2 Hl39e,Hl46e
mol_id molecule chains synonym
4 50S ribosomal protein L44e 3 HLA,La
mol_id molecule chains
5 QUINUPRISTIN 4
mol_id molecule chains
6 5S RIBOSOMAL RNA 9
mol_id molecule chains synonym
7 50S ribosomal protein L2 A Hl4,Hmal2
mol_id molecule chains synonym
8 50S ribosomal protein L3 B Hl1,Hmal3
mol_id molecule chains synonym
9 50S ribosomal protein L4 C Hl6,Hmal4
mol_id molecule chains synonym
10 50S ribosomal protein L5 D Hl13,Hmal5
mol_id molecule chains synonym
11 50S ribosomal protein L6 E Hl10,Hmal6
mol_id molecule chains synonym
12 50S ribosomal protein L7Ae F Hs6,Ribosomal protein L8e
mol_id molecule chains synonym
13 50S ribosomal protein L10 G Acidic ribosomal protein P0 homolog,HMal10,L10E
mol_id molecule chains
14 50S ribosomal protein L10e H
mol_id molecule chains synonym
15 50S ribosomal protein L11 I Hmal11
mol_id molecule chains synonym
16 50S ribosomal protein L13 J Hmal13
mol_id molecule chains synonym
17 50S ribosomal protein L14 K Hl27,Hmal14
mol_id molecule chains synonym
18 50S ribosomal protein L15 L Hl9,Hmal15
mol_id molecule chains synonym
19 50S ribosomal protein L15e M 50S ribosomal protein LC12
mol_id molecule chains synonym
20 50S ribosomal protein L18 N Hl12,Hmal18
mol_id molecule chains synonym
21 50S ribosomal protein L18e O Hl29,L19
mol_id molecule chains synonym
22 50S ribosomal protein L19e P Hl24,Hmal19
mol_id molecule chains synonym
23 50S ribosomal protein L21e Q Hl31
mol_id molecule chains synonym
24 50S ribosomal protein L22 R Hl23,Hmal22
mol_id molecule chains synonym
25 50S ribosomal protein L23 S Hl25,Hmal23,L21
mol_id molecule chains synonym
26 50S ribosomal protein L24 T Hl15,Hl16,Hmal24
mol_id molecule chains synonym
27 50S ribosomal protein L24e U Hl21/Hl22
mol_id molecule chains synonym
28 50S ribosomal protein L29 V Hl33,Hmal29
mol_id molecule chains synonym
29 50S ribosomal protein L30 W Hl16,Hl20,Hmal30
mol_id molecule chains synonym
30 50S ribosomal protein L31e X Hl30,L34
mol_id molecule chains synonym
31 50S ribosomal protein L32e Y Hl5
mol_id molecule chains synonym
32 50S ribosomal protein L37Ae Z Ribosomal protein L43e
Source :
mol_id organism_scientific
1 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
2 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
3 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
4 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
5 Streptomyces graminofaciens  (taxid:68212)
synthetic: yes
mol_id organism_scientific
6 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
7 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
8 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
9 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
10 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
11 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
12 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
13 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
14 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
15 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
16 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
17 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
18 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
19 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
20 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
21 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
22 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
23 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
24 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
25 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
26 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
27 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
28 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
29 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
30 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
31 Haloarcula marismortui  (taxid:2238)
strain: DT41
mol_id organism_scientific
32 Haloarcula marismortui  (taxid:2238)
strain: DT41
Authors : Tu, D., Blaha, G., Moore, P.B., Steitz, T.A.
Keywords : QUINUPRISTIN, DALFOPRISTIN, STREPTOGRAMIN, ANTIBIOTIC, MUTATED 50S SUBUNITS, RIBOSOME, RIBOSOME-ANTIBIOTIC COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Structures of Mlsbk Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance.

Tu, D.,Blaha, G.,Moore, P.B.  et al.
(2005)  Cell(Cambridge,Mass.)  121 : 257

PubMed: 15851032
DOI: 10.1016/J.CELL.2005.02.005

Reaction

Chain : 1
UniProt : P32410 (RL37_HALMA)
Reaction : -
Chain : 2
UniProt : P22452 (RL39_HALMA)
Reaction : -
Chain : 3
UniProt : P32411 (RL44E_HALMA)
Reaction : -
Chain : A
UniProt : P20276 (RL2_HALMA)
Reaction : -
Chain : B
UniProt : P20279 (RL3_HALMA)
Reaction : -
Chain : C
UniProt : P12735 (RL4_HALMA)
Reaction : -
Chain : D
UniProt : P14124 (RL5_HALMA)
Reaction : -
Chain : E
UniProt : P14135 (RL6_HALMA)
Reaction : -
Chain : F
UniProt : P12743 (RL7A_HALMA)
Reaction : -
Chain : G
UniProt : P15825 (RL10_HALMA)
Reaction : -
Chain : H
UniProt : P60617 (RL10E_HALMA)
Reaction : -
Chain : I
UniProt : P14122 (RL11_HALMA)
Reaction : -
Chain : J
UniProt : P29198 (RL13_HALMA)
Reaction : -
Chain : K
UniProt : P22450 (RL14_HALMA)
Reaction : -
Chain : L
UniProt : P12737 (RL15_HALMA)
Reaction : -
Chain : M
UniProt : P60618 (RL15E_HALMA)
Reaction : -
Chain : N
UniProt : P14123 (RL18_HALMA)
Reaction : -
Chain : O
UniProt : P12733 (RL18E_HALMA)
Reaction : -
Chain : P
UniProt : P14119 (RL19E_HALMA)
Reaction : -
Chain : Q
UniProt : P12734 (RL21_HALMA)
Reaction : -
Chain : R
UniProt : P10970 (RL22_HALMA)
Reaction : -
Chain : S
UniProt : P12732 (RL23_HALMA)
Reaction : -
Chain : T
UniProt : P10972 (RL24_HALMA)
Reaction : -
Chain : U
UniProt : P14116 (RL24E_HALMA)
Reaction : -
Chain : V
UniProt : P10971 (RL29_HALMA)
Reaction : -
Chain : W
UniProt : P14121 (RL30_HALMA)
Reaction : -
Chain : X
UniProt : P18138 (RL31_HALMA)
Reaction : -
Chain : Y
UniProt : P12736 (RL32_HALMA)
Reaction : -
Chain : Z
UniProt : P60619 (RL37A_HALMA)
Reaction : -