Brand  (β version)

PDB ID: 1XU7

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Ligands
Code Name Style Show Link
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
CPS 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate PoSSuM
Non-standard Residues
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Structure summary

Code : 1XU7   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of the Interface Open Conformation of Tetrameric 11b-HSD1
Release Data : 2004-11-02
Compound :
mol_id molecule chains synonym
1 Corticosteroid 11-beta-dehydrogenase, isozyme 1 A,B,C,D 11-DH, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1
ec: 1.1.1.146
mutation: C272S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HSD11B1, HSD11, HSD11L
expression_system_cell: DH10b-Tir
expression_system_vector_type: plasmid
expression_system_plasmid: pBAD-ThioE
Authors : Hosfield, D.J., Wu, Y., Skene, R.J., Hilger, M., Jennings, A., Snell, G.P., Aertgeerts, K.
Keywords : 11b-HSD1, SDR, dehydrogenase, hydroxysteroid, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Conformational Flexibility in Crystal Structures of Human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.

Hosfield, D.J.,Wu, Y.,Skene, R.J.  et al.
(2005)  J.Biol.Chem.  280 : 4639 - 4648

PubMed: 15513927
DOI: 10.1074/jbc.M411104200

Reaction

Chain : A, B, C, D
UniProt : P28845 (DHI1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH 1.1.1.146 PubMed:10497248, PubMed:11481269, PubMed:12460758, PubMed:14973125, PubMed:15152005, PubMed:15280030, PubMed:17070044, PubMed:17593962, PubMed:17919905, PubMed:21453287, PubMed:27927697, PubMed:30902677, PubMed:8319583
right-to-left PubMed:10497248, PubMed:11481269, PubMed:12460758, PubMed:14973125, PubMed:15152005, PubMed:21453287, PubMed:30902677, PubMed:8319583, PubMed:15280030, PubMed:17593962, PubMed:27927697
cortisone + H(+) + NADPH = cortisol + NADP(+) - PubMed:11481269, PubMed:12460758, PubMed:15152005, PubMed:15280030, PubMed:17593962, PubMed:21453287, PubMed:27927697, PubMed:30902677, PubMed:8319583
right-to-left PubMed:12460758, PubMed:15152005, PubMed:21453287, PubMed:30902677, PubMed:8319583, PubMed:15280030, PubMed:17593962, PubMed:27927697
corticosterone + NADP(+) = 11-dehydrocorticosterone + H(+) + NADPH - PubMed:10497248, PubMed:14973125
right-to-left
a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH 1.1.1.201 PubMed:14973125, PubMed:15095019, PubMed:15152005, PubMed:17593962, PubMed:21453287
right-to-left PubMed:14973125, PubMed:15095019, PubMed:15152005, PubMed:21453287, PubMed:17593962
7-oxocholesterol + H(+) + NADPH = 7beta-hydroxycholesterol + NADP(+) - PubMed:14973125, PubMed:15095019, PubMed:15152005
left-to-right
chenodeoxycholate + NADP(+) = 7-oxolithocholate + H(+) + NADPH - PubMed:21453287
right-to-left
7-oxolithocholate + H(+) + NADPH = NADP(+) + ursodeoxycholate - PubMed:21453287
left-to-right
glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH - PubMed:21453287
right-to-left
NADP(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH - PubMed:21453287
right-to-left
NADP(+) + tauroursodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH - PubMed:21453287
right-to-left
glycoursodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH - PubMed:21453287
right-to-left
7-oxopregnenolone + H(+) + NADPH = 7beta-hydroxypregnenolone + NADP(+) - PubMed:17593962
left-to-right
3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta- hydroxy-5-androstene-7,17-dione + H(+) + NADPH - PubMed:17593962
left-to-right
3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+) - PubMed:17593962
left-to-right
3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+) - PubMed:17593962
left-to-right