ID 1XU7A STANDARD; PRT; 286 AA. DT CONVERTED FROM PDB (SEQRES) 1XU7 DE Corticosteroid 11-beta-dehydrogenase, isozyme 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.800 CC R-Factor 0.198 FT #SUB 90 96 MET A 131 137 ARG B Protein S 1 FT #SUB 122 128 LEU A 194 200 GLU B Protein A 7 FT #SUB 122 128 LEU A 198 204 SER B Protein S 2 FT #SUB 123 129 PHE A 142 148 VAL B Protein S 1 FT #SUB 123 129 PHE A 146 152 VAL B Protein S 2 FT #SUB 123 129 PHE A 187 193 PHE B Protein S 6 FT #SUB 123 129 PHE A 191 197 ILE B Protein S 1 FT #SUB 123 129 PHE A 194 200 GLU B Protein A 5 FT #SUB 125 131 ASP A 146 152 VAL B Protein S 5 FT #SUB 127 133 ILE A 143 149 VAL B Protein S 1 FT #SUB 130 136 VAL A 138 144 PHE B Protein S 2 FT #SUB 130 136 VAL A 139 145 LEU B Protein S 1 FT #SUB 130 136 VAL A 187 193 PHE B Protein S 1 FT #SUB 131 137 ARG A 90 96 MET B Protein S 1 FT #SUB 131 137 ARG A 135 141 GLU B Protein S 2 FT #SUB 131 137 ARG A 139 145 LEU B Protein S 4 FT #SUB 134 140 MET A 134 140 MET B Protein S 1 FT #SUB 134 140 MET A 138 144 PHE B Protein S 2 FT #SUB 135 141 GLU A 131 137 ARG B Protein S 7 FT #SUB 138 144 PHE A 130 136 VAL B Protein S 2 FT #SUB 138 144 PHE A 134 140 MET B Protein S 2 FT #SUB 138 144 PHE A 179 185 ALA B Protein S 2 FT #SUB 139 145 LEU A 130 136 VAL B Protein S 1 FT #SUB 142 148 VAL A 123 129 PHE B Protein S 1 FT #SUB 143 149 VAL A 127 133 ILE B Protein S 1 FT #SUB 146 152 VAL A 123 129 PHE B Protein S 2 FT #SUB 146 152 VAL A 125 131 ASP B Protein S 4 FT #SUB 168 174 LYS A 267 273 ARG B Protein B 1 FT #SUB 169 175 VAL A 267 273 ARG B Protein A 6 FT #SUB 169 175 VAL A 270 276 LEU B Protein S 1 FT #SUB 169 175 VAL A 271 277 GLU B Protein A 3 FT #SUB 170 176 ALA A 189 195 SER B Protein S 3 FT #SUB 170 176 ALA A 190 196 SER B Protein S 1 FT #SUB 170 176 ALA A 193 199 LYS B Protein A 5 FT #SUB 170 176 ALA A 267 273 ARG B Protein S 1 FT #SUB 170 176 ALA A 271 277 GLU B Protein A 9 FT #SUB 171 177 TYR A 190 196 SER B Protein B 4 FT #SUB 171 177 TYR A 274 280 TYR B Protein S 8 FT #SUB 172 178 PRO A 190 196 SER B Protein B 2 FT #SUB 172 178 PRO A 193 199 LYS B Protein A 2 FT #SUB 172 178 PRO A 194 200 GLU B Protein A 3 FT #SUB 172 178 PRO A 274 280 TYR B Protein S 1 FT #SUB 173 179 MET A 194 200 GLU B Protein B 4 FT #SUB 173 179 MET A 197 203 VAL B Protein S 1 FT #SUB 174 180 VAL A 190 196 SER B Protein B 1 FT #SUB 175 181 ALA A 187 193 PHE B Protein A 5 FT #SUB 175 181 ALA A 190 196 SER B Protein A 5 FT #SUB 175 181 ALA A 191 197 ILE B Protein S 1 FT #SUB 178 184 SER A 186 192 GLY B Protein S 4 FT #SUB 179 185 ALA A 138 144 PHE B Protein S 2 FT #SUB 179 185 ALA A 183 189 ALA B Protein A 4 FT #SUB 179 185 ALA A 187 193 PHE B Protein S 1 FT #SUB 182 188 PHE A 182 188 PHE B Protein A 8 FT #SUB 182 188 PHE A 185 191 ASP B Protein S 2 FT #SUB 182 188 PHE A 186 192 GLY B Protein S 7 FT #SUB 182 188 PHE A 267 273 ARG B Protein S 2 FT #SUB 183 189 ALA A 179 185 ALA B Protein A 4 FT #SUB 185 191 ASP A 182 188 PHE B Protein S 2 FT #SUB 186 192 GLY A 178 184 SER B Protein B 4 FT #SUB 186 192 GLY A 182 188 PHE B Protein B 7 FT #SUB 187 193 PHE A 123 129 PHE B Protein S 6 FT #SUB 187 193 PHE A 130 136 VAL B Protein S 1 FT #SUB 187 193 PHE A 175 181 ALA B Protein A 5 FT #SUB 187 193 PHE A 176 182 ALA B Protein S 1 FT #SUB 187 193 PHE A 179 185 ALA B Protein S 1 FT #SUB 189 195 SER A 170 176 ALA B Protein A 3 FT #SUB 190 196 SER A 170 176 ALA B Protein B 1 FT #SUB 190 196 SER A 171 177 TYR B Protein A 4 FT #SUB 190 196 SER A 172 178 PRO B Protein A 2 FT #SUB 190 196 SER A 174 180 VAL B Protein S 1 FT #SUB 190 196 SER A 175 181 ALA B Protein S 5 FT #SUB 191 197 ILE A 123 129 PHE B Protein S 1 FT #SUB 191 197 ILE A 175 181 ALA B Protein S 1 FT #SUB 193 199 LYS A 170 176 ALA B Protein S 1 FT #SUB 193 199 LYS A 172 178 PRO B Protein S 4 FT #SUB 194 200 GLU A 121 127 ASN B Protein S 1 FT #SUB 194 200 GLU A 122 128 LEU B Protein S 5 FT #SUB 194 200 GLU A 123 129 PHE B Protein S 5 FT #SUB 194 200 GLU A 172 178 PRO B Protein S 3 FT #SUB 194 200 GLU A 173 179 MET B Protein S 5 FT #SUB 198 204 SER A 122 128 LEU B Protein S 2 FT #SUB 261 267 LEU A 266 272 SER B Protein A 5 FT #SUB 261 267 LEU A 269 275 ILE B Protein S 1 FT #SUB 261 267 LEU A 270 276 LEU B Protein S 2 FT #SUB 262 268 ILE A 270 276 LEU B Protein S 1 FT #SUB 264 270 ASN A 264 270 ASN B Protein S 3 FT #SUB 266 272 SER A 261 267 LEU B Protein A 6 FT #SUB 267 273 ARG A 168 174 LYS B Protein S 1 FT #SUB 267 273 ARG A 169 175 VAL B Protein A 5 FT #SUB 267 273 ARG A 170 176 ALA B Protein S 2 FT #SUB 267 273 ARG A 182 188 PHE B Protein S 2 FT #SUB 269 275 ILE A 261 267 LEU B Protein S 1 FT #SUB 270 276 LEU A 261 267 LEU B Protein S 5 FT #SUB 270 276 LEU A 262 268 ILE B Protein S 1 FT #SUB 271 277 GLU A 169 175 VAL B Protein S 3 FT #SUB 271 277 GLU A 170 176 ALA B Protein S 7 FT #SUB 274 280 TYR A 171 177 TYR B Protein S 7 FT #SUB 274 280 TYR A 225 231 VAL B Protein S 1 FT #SUB 274 280 TYR A 227 233 MET B Protein S 1 FT #SUB 277 283 SER A 227 233 MET B Protein S 2 FT #SUB 257 263 TRP A 273 279 LEU C Protein S 1 FT #SUB 269 275 ILE A 257 263 TRP C Protein S 1 FT #SUB 273 279 LEU A 257 263 TRP C Protein S 2 FT #HET 35 41 GLY A 1 522 NDP A B 8 FT #HET 36 42 ALA A 1 522 NDP A B 1 FT #HET 37 43 SER A 1 522 NDP A A 8 FT #HET 38 44 LYS A 1 522 NDP A A 8 FT #HET 39 45 GLY A 1 522 NDP A B 4 FT #HET 40 46 ILE A 1 522 NDP A A 10 FT #HET 59 65 ALA A 1 522 NDP A A 6 FT #HET 60 66 ARG A 1 522 NDP A A 31 FT #HET 61 67 SER A 1 522 NDP A A 2 FT #HET 85 91 GLY A 1 522 NDP A B 1 FT #HET 86 92 THR A 1 522 NDP A A 6 FT #HET 87 93 MET A 1 522 NDP A A 9 FT #HET 88 94 GLU A 1 522 NDP A S 1 FT #HET 113 119 ASN A 1 522 NDP A A 10 FT #HET 114 120 HIS A 1 522 NDP A A 3 FT #HET 115 121 ILE A 1 522 NDP A A 13 FT #HET 115 121 ILE A 2 523 CPS A S 3 FT #HET 117 123 ASN A 1 522 NDP A S 1 FT #HET 118 124 THR A 2 523 CPS A S 1 FT #HET 120 126 LEU A 2 523 CPS A S 2 FT #HET 162 168 VAL A 1 522 NDP A A 4 FT #HET 163 169 SER A 1 522 NDP A B 1 FT #HET 164 170 SER A 1 522 NDP A A 6 FT #HET 165 171 LEU A 2 523 CPS A S 4 FT #HET 166 172 ALA A 2 523 CPS A S 1 FT #HET 171 177 TYR A 2 523 CPS A S 10 FT #HET 177 183 TYR A 1 522 NDP A S 8 FT #HET 177 183 TYR A 2 523 CPS A S 17 FT #HET 181 187 LYS A 1 522 NDP A S 5 FT #HET 209 215 LEU A 1 522 NDP A A 5 FT #HET 210 216 GLY A 1 522 NDP A B 4 FT #HET 211 217 LEU A 1 522 NDP A A 3 FT #HET 211 217 LEU A 2 523 CPS A A 4 FT #HET 212 218 ILE A 1 522 NDP A A 11 FT #HET 214 220 THR A 1 522 NDP A S 9 FT #HET 216 222 THR A 1 522 NDP A S 5 FT #HET 217 223 ALA A 1 522 NDP A S 3 FT #HET 217 223 ALA A 2 523 CPS A A 4 FT #HET 220 226 ALA A 2 523 CPS A S 1 FT #HET 221 227 VAL A 2 523 CPS A S 3 FT #HET 228 234 GLN A 2 523 CPS A S 7 FT #HET 254 260 SER A 2 523 CPS A S 1 FT #HET 255 261 SER A 2 523 CPS A S 3 FT #HET 258 264 THR A 2 523 CPS A S 2 FT #HET 260 266 LEU A 8 2 CPS C A 2 FT #HET 265 271 PRO A 3 1 CPS A S 5 FT #HET 266 272 SER A 3 1 CPS A S 3 FT #HET 269 275 ILE A 3 1 CPS A S 2 FT #HET 270 276 LEU A 5 525 CPS B S 1 FT #HET 273 279 LEU A 5 525 CPS B S 2 FT #HET 274 280 TYR A 5 525 CPS B S 3 FT DISORDER 1 14 FT DISORDER 278 286 CC SEQUENCE 263 AA (ATOM); CC QPLNEEFRPE MLQGKKVIVT GASKGIGREM AYHLAKMGAH VVVTARSKET LQKVVSHCLE CC LGAASAHYIA GTMEDMTFAE QFVAQAGKLM GGLDMLILNH ITNTSLNLFH DDIHHVRKSM CC EVNFLSYVVL TVAALPMLKQ SNGSIVVVSS LAGKVAYPMV AAYSASKFAL DGFFSSIRKE CC YSVSRVNVSI TLCVLGLIDT ETAMKAVSGI VHMQAAPKEE CALEIIKGGA LRQEEVYYDS CC SLWTTLLIRN PSRKILEFLY STS CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MKHQHQHQHQHQHQQPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ATOM --------------QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ************************************ CC SEQRES MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ATOM MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ************************************************** CC SEQRES GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ATOM GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ************************************************** CC SEQRES MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ATOM MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ************************************************** CC SEQRES NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ATOM NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ************************************************** CC SEQRES YYDSSLWTTLLIRNPSRKILEFLYSTSYNMDRFINK CC ATOM YYDSSLWTTLLIRNPSRKILEFLYSTS--------- CC *************************** SQ SEQUENCE 286 AA; MW; CN; MKHQHQHQHQ HQHQQPLNEE FRPEMLQGKK VIVTGASKGI GREMAYHLAK MGAHVVVTAR SKETLQKVVS HCLELGAASA HYIAGTMEDM TFAEQFVAQA GKLMGGLDML ILNHITNTSL NLFHDDIHHV RKSMEVNFLS YVVLTVAALP MLKQSNGSIV VVSSLAGKVA YPMVAAYSAS KFALDGFFSS IRKEYSVSRV NVSITLCVLG LIDTETAMKA VSGIVHMQAA PKEECALEII KGGALRQEEV YYDSSLWTTL LIRNPSRKIL EFLYSTSYNM DRFINK // ID 1XU7B STANDARD; PRT; 286 AA. DT CONVERTED FROM PDB (SEQRES) 1XU7 DE Corticosteroid 11-beta-dehydrogenase, isozyme 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.800 CC R-Factor 0.198 FT #SUB 90 96 MET B 131 137 ARG A Protein S 1 FT #SUB 121 127 ASN B 194 200 GLU A Protein B 1 FT #SUB 122 128 LEU B 194 200 GLU A Protein A 5 FT #SUB 122 128 LEU B 198 204 SER A Protein S 2 FT #SUB 123 129 PHE B 142 148 VAL A Protein S 1 FT #SUB 123 129 PHE B 146 152 VAL A Protein S 2 FT #SUB 123 129 PHE B 187 193 PHE A Protein S 6 FT #SUB 123 129 PHE B 191 197 ILE A Protein S 1 FT #SUB 123 129 PHE B 194 200 GLU A Protein A 5 FT #SUB 125 131 ASP B 146 152 VAL A Protein A 4 FT #SUB 127 133 ILE B 143 149 VAL A Protein S 1 FT #SUB 130 136 VAL B 138 144 PHE A Protein S 2 FT #SUB 130 136 VAL B 139 145 LEU A Protein S 1 FT #SUB 130 136 VAL B 187 193 PHE A Protein S 1 FT #SUB 131 137 ARG B 90 96 MET A Protein S 1 FT #SUB 131 137 ARG B 135 141 GLU A Protein S 7 FT #SUB 134 140 MET B 134 140 MET A Protein S 1 FT #SUB 134 140 MET B 138 144 PHE A Protein S 2 FT #SUB 135 141 GLU B 131 137 ARG A Protein S 2 FT #SUB 138 144 PHE B 130 136 VAL A Protein S 2 FT #SUB 138 144 PHE B 134 140 MET A Protein S 2 FT #SUB 138 144 PHE B 179 185 ALA A Protein S 2 FT #SUB 139 145 LEU B 130 136 VAL A Protein S 1 FT #SUB 139 145 LEU B 131 137 ARG A Protein S 4 FT #SUB 142 148 VAL B 123 129 PHE A Protein S 1 FT #SUB 143 149 VAL B 127 133 ILE A Protein S 1 FT #SUB 146 152 VAL B 123 129 PHE A Protein S 2 FT #SUB 146 152 VAL B 125 131 ASP A Protein S 5 FT #SUB 168 174 LYS B 267 273 ARG A Protein B 1 FT #SUB 169 175 VAL B 267 273 ARG A Protein A 5 FT #SUB 169 175 VAL B 271 277 GLU A Protein A 3 FT #SUB 170 176 ALA B 189 195 SER A Protein S 3 FT #SUB 170 176 ALA B 190 196 SER A Protein S 1 FT #SUB 170 176 ALA B 193 199 LYS A Protein B 1 FT #SUB 170 176 ALA B 267 273 ARG A Protein A 2 FT #SUB 170 176 ALA B 271 277 GLU A Protein A 7 FT #SUB 171 177 TYR B 190 196 SER A Protein B 4 FT #SUB 171 177 TYR B 274 280 TYR A Protein S 7 FT #SUB 172 178 PRO B 190 196 SER A Protein B 2 FT #SUB 172 178 PRO B 193 199 LYS A Protein A 4 FT #SUB 172 178 PRO B 194 200 GLU A Protein A 3 FT #SUB 173 179 MET B 194 200 GLU A Protein B 5 FT #SUB 174 180 VAL B 190 196 SER A Protein B 1 FT #SUB 175 181 ALA B 187 193 PHE A Protein A 5 FT #SUB 175 181 ALA B 190 196 SER A Protein A 5 FT #SUB 175 181 ALA B 191 197 ILE A Protein S 1 FT #SUB 176 182 ALA B 187 193 PHE A Protein B 1 FT #SUB 178 184 SER B 186 192 GLY A Protein S 4 FT #SUB 179 185 ALA B 138 144 PHE A Protein S 2 FT #SUB 179 185 ALA B 183 189 ALA A Protein A 4 FT #SUB 179 185 ALA B 187 193 PHE A Protein S 1 FT #SUB 182 188 PHE B 182 188 PHE A Protein A 8 FT #SUB 182 188 PHE B 185 191 ASP A Protein S 2 FT #SUB 182 188 PHE B 186 192 GLY A Protein S 7 FT #SUB 182 188 PHE B 267 273 ARG A Protein S 2 FT #SUB 183 189 ALA B 179 185 ALA A Protein A 4 FT #SUB 185 191 ASP B 182 188 PHE A Protein S 2 FT #SUB 186 192 GLY B 178 184 SER A Protein B 4 FT #SUB 186 192 GLY B 182 188 PHE A Protein B 7 FT #SUB 187 193 PHE B 123 129 PHE A Protein S 6 FT #SUB 187 193 PHE B 130 136 VAL A Protein S 1 FT #SUB 187 193 PHE B 175 181 ALA A Protein A 5 FT #SUB 187 193 PHE B 179 185 ALA A Protein S 1 FT #SUB 189 195 SER B 170 176 ALA A Protein A 3 FT #SUB 190 196 SER B 170 176 ALA A Protein B 1 FT #SUB 190 196 SER B 171 177 TYR A Protein A 4 FT #SUB 190 196 SER B 172 178 PRO A Protein A 2 FT #SUB 190 196 SER B 174 180 VAL A Protein S 1 FT #SUB 190 196 SER B 175 181 ALA A Protein S 5 FT #SUB 191 197 ILE B 123 129 PHE A Protein S 1 FT #SUB 191 197 ILE B 175 181 ALA A Protein S 1 FT #SUB 193 199 LYS B 170 176 ALA A Protein S 5 FT #SUB 193 199 LYS B 172 178 PRO A Protein S 2 FT #SUB 194 200 GLU B 122 128 LEU A Protein S 7 FT #SUB 194 200 GLU B 123 129 PHE A Protein S 5 FT #SUB 194 200 GLU B 172 178 PRO A Protein S 3 FT #SUB 194 200 GLU B 173 179 MET A Protein S 4 FT #SUB 197 203 VAL B 173 179 MET A Protein S 1 FT #SUB 198 204 SER B 122 128 LEU A Protein S 2 FT #SUB 225 231 VAL B 274 280 TYR A Protein S 1 FT #SUB 227 233 MET B 274 280 TYR A Protein S 1 FT #SUB 227 233 MET B 277 283 SER A Protein S 2 FT #SUB 261 267 LEU B 266 272 SER A Protein A 6 FT #SUB 261 267 LEU B 269 275 ILE A Protein S 1 FT #SUB 261 267 LEU B 270 276 LEU A Protein S 5 FT #SUB 262 268 ILE B 270 276 LEU A Protein S 1 FT #SUB 264 270 ASN B 264 270 ASN A Protein S 3 FT #SUB 266 272 SER B 261 267 LEU A Protein A 5 FT #SUB 267 273 ARG B 168 174 LYS A Protein S 1 FT #SUB 267 273 ARG B 169 175 VAL A Protein A 6 FT #SUB 267 273 ARG B 170 176 ALA A Protein S 1 FT #SUB 267 273 ARG B 182 188 PHE A Protein S 2 FT #SUB 269 275 ILE B 261 267 LEU A Protein S 1 FT #SUB 270 276 LEU B 169 175 VAL A Protein S 1 FT #SUB 270 276 LEU B 261 267 LEU A Protein S 2 FT #SUB 270 276 LEU B 262 268 ILE A Protein S 1 FT #SUB 271 277 GLU B 169 175 VAL A Protein S 3 FT #SUB 271 277 GLU B 170 176 ALA A Protein S 9 FT #SUB 274 280 TYR B 171 177 TYR A Protein S 8 FT #SUB 274 280 TYR B 172 178 PRO A Protein S 1 FT #SUB 257 263 TRP B 269 275 ILE D Protein S 1 FT #SUB 257 263 TRP B 273 279 LEU D Protein S 3 FT #SUB 260 266 LEU B 269 275 ILE D Protein S 1 FT #SUB 273 279 LEU B 257 263 TRP D Protein S 1 FT #HET 35 41 GLY B 4 524 NDP B B 8 FT #HET 36 42 ALA B 4 524 NDP B B 1 FT #HET 37 43 SER B 4 524 NDP B A 8 FT #HET 38 44 LYS B 4 524 NDP B A 9 FT #HET 39 45 GLY B 4 524 NDP B B 4 FT #HET 40 46 ILE B 4 524 NDP B A 10 FT #HET 59 65 ALA B 4 524 NDP B A 6 FT #HET 60 66 ARG B 4 524 NDP B A 30 FT #HET 61 67 SER B 4 524 NDP B A 3 FT #HET 85 91 GLY B 4 524 NDP B B 1 FT #HET 86 92 THR B 4 524 NDP B A 5 FT #HET 87 93 MET B 4 524 NDP B A 9 FT #HET 88 94 GLU B 4 524 NDP B S 1 FT #HET 113 119 ASN B 4 524 NDP B A 9 FT #HET 114 120 HIS B 4 524 NDP B A 3 FT #HET 115 121 ILE B 4 524 NDP B A 14 FT #HET 115 121 ILE B 5 525 CPS B S 3 FT #HET 116 122 THR B 4 524 NDP B B 1 FT #HET 118 124 THR B 5 525 CPS B S 1 FT #HET 120 126 LEU B 5 525 CPS B S 1 FT #HET 136 142 VAL B 4 524 NDP B S 1 FT #HET 162 168 VAL B 4 524 NDP B A 5 FT #HET 163 169 SER B 4 524 NDP B B 2 FT #HET 164 170 SER B 4 524 NDP B A 7 FT #HET 165 171 LEU B 5 525 CPS B S 5 FT #HET 166 172 ALA B 5 525 CPS B S 1 FT #HET 171 177 TYR B 5 525 CPS B S 10 FT #HET 177 183 TYR B 4 524 NDP B S 7 FT #HET 177 183 TYR B 5 525 CPS B S 17 FT #HET 181 187 LYS B 4 524 NDP B S 4 FT #HET 209 215 LEU B 4 524 NDP B A 5 FT #HET 210 216 GLY B 4 524 NDP B B 4 FT #HET 211 217 LEU B 4 524 NDP B A 3 FT #HET 211 217 LEU B 5 525 CPS B A 4 FT #HET 212 218 ILE B 4 524 NDP B A 10 FT #HET 214 220 THR B 4 524 NDP B S 9 FT #HET 216 222 THR B 4 524 NDP B S 5 FT #HET 217 223 ALA B 4 524 NDP B S 3 FT #HET 217 223 ALA B 5 525 CPS B A 4 FT #HET 220 226 ALA B 5 525 CPS B S 2 FT #HET 221 227 VAL B 5 525 CPS B S 2 FT #HET 226 232 HIS B 5 525 CPS B B 1 FT #HET 227 233 MET B 5 525 CPS B A 11 FT #HET 228 234 GLN B 5 525 CPS B A 5 FT #HET 253 259 ASP B 5 525 CPS B S 2 FT #HET 258 264 THR B 5 525 CPS B S 3 FT #HET 265 271 PRO B 8 2 CPS C S 1 FT #HET 266 272 SER B 8 2 CPS C S 2 FT #HET 269 275 ILE B 8 2 CPS C S 1 FT #HET 273 279 LEU B 2 523 CPS A A 3 FT #HET 274 280 TYR B 2 523 CPS A S 2 FT DISORDER 1 14 FT DISORDER 277 286 CC SEQUENCE 262 AA (ATOM); CC QPLNEEFRPE MLQGKKVIVT GASKGIGREM AYHLAKMGAH VVVTARSKET LQKVVSHCLE CC LGAASAHYIA GTMEDMTFAE QFVAQAGKLM GGLDMLILNH ITNTSLNLFH DDIHHVRKSM CC EVNFLSYVVL TVAALPMLKQ SNGSIVVVSS LAGKVAYPMV AAYSASKFAL DGFFSSIRKE CC YSVSRVNVSI TLCVLGLIDT ETAMKAVSGI VHMQAAPKEE CALEIIKGGA LRQEEVYYDS CC SLWTTLLIRN PSRKILEFLY ST CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MKHQHQHQHQHQHQQPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ATOM --------------QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ************************************ CC SEQRES MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ATOM MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ************************************************** CC SEQRES GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ATOM GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ************************************************** CC SEQRES MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ATOM MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ************************************************** CC SEQRES NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ATOM NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ************************************************** CC SEQRES YYDSSLWTTLLIRNPSRKILEFLYSTSYNMDRFINK CC ATOM YYDSSLWTTLLIRNPSRKILEFLYST---------- CC ************************** SQ SEQUENCE 286 AA; MW; CN; MKHQHQHQHQ HQHQQPLNEE FRPEMLQGKK VIVTGASKGI GREMAYHLAK MGAHVVVTAR SKETLQKVVS HCLELGAASA HYIAGTMEDM TFAEQFVAQA GKLMGGLDML ILNHITNTSL NLFHDDIHHV RKSMEVNFLS YVVLTVAALP MLKQSNGSIV VVSSLAGKVA YPMVAAYSAS KFALDGFFSS IRKEYSVSRV NVSITLCVLG LIDTETAMKA VSGIVHMQAA PKEECALEII KGGALRQEEV YYDSSLWTTL LIRNPSRKIL EFLYSTSYNM DRFINK // ID 1XU7C STANDARD; PRT; 286 AA. DT CONVERTED FROM PDB (SEQRES) 1XU7 DE Corticosteroid 11-beta-dehydrogenase, isozyme 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.800 CC R-Factor 0.198 FT #SUB 257 263 TRP C 269 275 ILE A Protein S 1 FT #SUB 257 263 TRP C 273 279 LEU A Protein S 2 FT #SUB 273 279 LEU C 257 263 TRP A Protein S 1 FT #SUB 90 96 MET C 131 137 ARG D Protein S 1 FT #SUB 121 127 ASN C 194 200 GLU D Protein B 1 FT #SUB 122 128 LEU C 194 200 GLU D Protein A 7 FT #SUB 122 128 LEU C 198 204 SER D Protein S 2 FT #SUB 123 129 PHE C 142 148 VAL D Protein S 1 FT #SUB 123 129 PHE C 146 152 VAL D Protein S 2 FT #SUB 123 129 PHE C 187 193 PHE D Protein S 8 FT #SUB 123 129 PHE C 191 197 ILE D Protein S 1 FT #SUB 123 129 PHE C 194 200 GLU D Protein A 5 FT #SUB 125 131 ASP C 146 152 VAL D Protein A 5 FT #SUB 127 133 ILE C 143 149 VAL D Protein S 1 FT #SUB 127 133 ILE C 146 152 VAL D Protein S 1 FT #SUB 130 136 VAL C 138 144 PHE D Protein S 2 FT #SUB 130 136 VAL C 139 145 LEU D Protein S 1 FT #SUB 130 136 VAL C 187 193 PHE D Protein S 1 FT #SUB 131 137 ARG C 90 96 MET D Protein S 1 FT #SUB 131 137 ARG C 135 141 GLU D Protein S 2 FT #SUB 131 137 ARG C 139 145 LEU D Protein S 3 FT #SUB 134 140 MET C 134 140 MET D Protein S 3 FT #SUB 134 140 MET C 138 144 PHE D Protein S 2 FT #SUB 138 144 PHE C 130 136 VAL D Protein S 2 FT #SUB 138 144 PHE C 134 140 MET D Protein S 2 FT #SUB 138 144 PHE C 179 185 ALA D Protein S 2 FT #SUB 139 145 LEU C 131 137 ARG D Protein S 1 FT #SUB 142 148 VAL C 123 129 PHE D Protein S 1 FT #SUB 146 152 VAL C 123 129 PHE D Protein S 2 FT #SUB 146 152 VAL C 125 131 ASP D Protein S 5 FT #SUB 146 152 VAL C 127 133 ILE D Protein S 3 FT #SUB 168 174 LYS C 267 273 ARG D Protein B 1 FT #SUB 169 175 VAL C 267 273 ARG D Protein A 5 FT #SUB 169 175 VAL C 271 277 GLU D Protein A 3 FT #SUB 170 176 ALA C 189 195 SER D Protein S 3 FT #SUB 170 176 ALA C 190 196 SER D Protein S 1 FT #SUB 170 176 ALA C 193 199 LYS D Protein A 5 FT #SUB 170 176 ALA C 271 277 GLU D Protein A 8 FT #SUB 171 177 TYR C 190 196 SER D Protein B 4 FT #SUB 171 177 TYR C 274 280 TYR D Protein S 6 FT #SUB 172 178 PRO C 190 196 SER D Protein B 1 FT #SUB 172 178 PRO C 193 199 LYS D Protein S 1 FT #SUB 172 178 PRO C 194 200 GLU D Protein A 3 FT #SUB 172 178 PRO C 274 280 TYR D Protein S 2 FT #SUB 173 179 MET C 194 200 GLU D Protein B 5 FT #SUB 174 180 VAL C 190 196 SER D Protein B 1 FT #SUB 175 181 ALA C 187 193 PHE D Protein A 5 FT #SUB 175 181 ALA C 190 196 SER D Protein A 5 FT #SUB 175 181 ALA C 191 197 ILE D Protein S 1 FT #SUB 178 184 SER C 186 192 GLY D Protein S 4 FT #SUB 179 185 ALA C 138 144 PHE D Protein S 2 FT #SUB 179 185 ALA C 183 189 ALA D Protein A 4 FT #SUB 179 185 ALA C 187 193 PHE D Protein S 1 FT #SUB 182 188 PHE C 182 188 PHE D Protein A 8 FT #SUB 182 188 PHE C 185 191 ASP D Protein S 2 FT #SUB 182 188 PHE C 186 192 GLY D Protein S 7 FT #SUB 182 188 PHE C 267 273 ARG D Protein S 2 FT #SUB 183 189 ALA C 179 185 ALA D Protein A 4 FT #SUB 185 191 ASP C 182 188 PHE D Protein S 2 FT #SUB 186 192 GLY C 178 184 SER D Protein B 4 FT #SUB 186 192 GLY C 182 188 PHE D Protein B 7 FT #SUB 187 193 PHE C 123 129 PHE D Protein S 7 FT #SUB 187 193 PHE C 130 136 VAL D Protein S 1 FT #SUB 187 193 PHE C 175 181 ALA D Protein A 5 FT #SUB 187 193 PHE C 179 185 ALA D Protein S 1 FT #SUB 189 195 SER C 170 176 ALA D Protein A 3 FT #SUB 190 196 SER C 170 176 ALA D Protein B 1 FT #SUB 190 196 SER C 171 177 TYR D Protein A 4 FT #SUB 190 196 SER C 172 178 PRO D Protein B 1 FT #SUB 190 196 SER C 175 181 ALA D Protein S 2 FT #SUB 190 196 SER C 178 184 SER D Protein S 2 FT #SUB 191 197 ILE C 123 129 PHE D Protein S 1 FT #SUB 191 197 ILE C 175 181 ALA D Protein S 1 FT #SUB 193 199 LYS C 170 176 ALA D Protein S 5 FT #SUB 193 199 LYS C 172 178 PRO D Protein S 2 FT #SUB 194 200 GLU C 122 128 LEU D Protein S 6 FT #SUB 194 200 GLU C 123 129 PHE D Protein S 5 FT #SUB 194 200 GLU C 172 178 PRO D Protein S 3 FT #SUB 194 200 GLU C 173 179 MET D Protein S 5 FT #SUB 194 200 GLU C 174 180 VAL D Protein S 1 FT #SUB 198 204 SER C 122 128 LEU D Protein S 2 FT #SUB 225 231 VAL C 274 280 TYR D Protein S 1 FT #SUB 227 233 MET C 274 280 TYR D Protein S 2 FT #SUB 261 267 LEU C 266 272 SER D Protein A 6 FT #SUB 261 267 LEU C 269 275 ILE D Protein S 2 FT #SUB 261 267 LEU C 270 276 LEU D Protein S 1 FT #SUB 264 270 ASN C 264 270 ASN D Protein S 3 FT #SUB 266 272 SER C 261 267 LEU D Protein A 6 FT #SUB 267 273 ARG C 168 174 LYS D Protein S 1 FT #SUB 267 273 ARG C 169 175 VAL D Protein A 5 FT #SUB 267 273 ARG C 182 188 PHE D Protein S 2 FT #SUB 269 275 ILE C 261 267 LEU D Protein S 2 FT #SUB 270 276 LEU C 169 175 VAL D Protein S 1 FT #SUB 270 276 LEU C 261 267 LEU D Protein S 6 FT #SUB 271 277 GLU C 169 175 VAL D Protein S 3 FT #SUB 271 277 GLU C 170 176 ALA D Protein S 8 FT #SUB 274 280 TYR C 171 177 TYR D Protein S 9 FT #SUB 274 280 TYR C 172 178 PRO D Protein S 2 FT #SUB 274 280 TYR C 225 231 VAL D Protein S 1 FT #SUB 274 280 TYR C 227 233 MET D Protein S 1 FT #HET 35 41 GLY C 6 526 NDP C B 8 FT #HET 36 42 ALA C 6 526 NDP C B 1 FT #HET 37 43 SER C 6 526 NDP C A 11 FT #HET 38 44 LYS C 6 526 NDP C A 8 FT #HET 39 45 GLY C 6 526 NDP C B 4 FT #HET 40 46 ILE C 6 526 NDP C A 8 FT #HET 59 65 ALA C 6 526 NDP C A 6 FT #HET 60 66 ARG C 6 526 NDP C A 29 FT #HET 61 67 SER C 6 526 NDP C A 3 FT #HET 85 91 GLY C 6 526 NDP C B 1 FT #HET 86 92 THR C 6 526 NDP C A 5 FT #HET 87 93 MET C 6 526 NDP C A 9 FT #HET 88 94 GLU C 6 526 NDP C S 1 FT #HET 113 119 ASN C 6 526 NDP C A 11 FT #HET 114 120 HIS C 6 526 NDP C A 3 FT #HET 115 121 ILE C 6 526 NDP C A 13 FT #HET 115 121 ILE C 7 527 CPS C S 3 FT #HET 118 124 THR C 7 527 CPS C S 2 FT #HET 120 126 LEU C 7 527 CPS C S 2 FT #HET 162 168 VAL C 6 526 NDP C A 5 FT #HET 163 169 SER C 6 526 NDP C B 2 FT #HET 164 170 SER C 6 526 NDP C A 6 FT #HET 164 170 SER C 7 527 CPS C S 1 FT #HET 165 171 LEU C 7 527 CPS C S 5 FT #HET 166 172 ALA C 7 527 CPS C S 1 FT #HET 171 177 TYR C 7 527 CPS C S 9 FT #HET 177 183 TYR C 6 526 NDP C S 7 FT #HET 177 183 TYR C 7 527 CPS C S 17 FT #HET 181 187 LYS C 6 526 NDP C S 4 FT #HET 209 215 LEU C 6 526 NDP C A 5 FT #HET 210 216 GLY C 6 526 NDP C B 5 FT #HET 211 217 LEU C 6 526 NDP C A 3 FT #HET 211 217 LEU C 7 527 CPS C A 4 FT #HET 212 218 ILE C 6 526 NDP C A 10 FT #HET 214 220 THR C 6 526 NDP C S 8 FT #HET 216 222 THR C 6 526 NDP C S 7 FT #HET 216 222 THR C 7 527 CPS C S 1 FT #HET 217 223 ALA C 6 526 NDP C S 3 FT #HET 217 223 ALA C 7 527 CPS C A 4 FT #HET 220 226 ALA C 7 527 CPS C S 2 FT #HET 221 227 VAL C 7 527 CPS C S 2 FT #HET 225 231 VAL C 7 527 CPS C S 1 FT #HET 227 233 MET C 7 527 CPS C A 8 FT #HET 228 234 GLN C 7 527 CPS C A 4 FT #HET 258 264 THR C 7 527 CPS C S 2 FT #HET 260 266 LEU C 3 1 CPS A A 6 FT #HET 265 271 PRO C 3 1 CPS A S 2 FT #HET 265 271 PRO C 8 2 CPS C S 2 FT #HET 266 272 SER C 8 2 CPS C A 7 FT #HET 269 275 ILE C 8 2 CPS C S 2 FT #HET 273 279 LEU C 10 529 CPS D S 1 FT #HET 274 280 TYR C 10 529 CPS D S 2 FT DISORDER 1 14 FT DISORDER 277 286 CC SEQUENCE 262 AA (ATOM); CC QPLNEEFRPE MLQGKKVIVT GASKGIGREM AYHLAKMGAH VVVTARSKET LQKVVSHCLE CC LGAASAHYIA GTMEDMTFAE QFVAQAGKLM GGLDMLILNH ITNTSLNLFH DDIHHVRKSM CC EVNFLSYVVL TVAALPMLKQ SNGSIVVVSS LAGKVAYPMV AAYSASKFAL DGFFSSIRKE CC YSVSRVNVSI TLCVLGLIDT ETAMKAVSGI VHMQAAPKEE CALEIIKGGA LRQEEVYYDS CC SLWTTLLIRN PSRKILEFLY ST CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MKHQHQHQHQHQHQQPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ATOM --------------QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ************************************ CC SEQRES MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ATOM MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ************************************************** CC SEQRES GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ATOM GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ************************************************** CC SEQRES MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ATOM MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ************************************************** CC SEQRES NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ATOM NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ************************************************** CC SEQRES YYDSSLWTTLLIRNPSRKILEFLYSTSYNMDRFINK CC ATOM YYDSSLWTTLLIRNPSRKILEFLYST---------- CC ************************** SQ SEQUENCE 286 AA; MW; CN; MKHQHQHQHQ HQHQQPLNEE FRPEMLQGKK VIVTGASKGI GREMAYHLAK MGAHVVVTAR SKETLQKVVS HCLELGAASA HYIAGTMEDM TFAEQFVAQA GKLMGGLDML ILNHITNTSL NLFHDDIHHV RKSMEVNFLS YVVLTVAALP MLKQSNGSIV VVSSLAGKVA YPMVAAYSAS KFALDGFFSS IRKEYSVSRV NVSITLCVLG LIDTETAMKA VSGIVHMQAA PKEECALEII KGGALRQEEV YYDSSLWTTL LIRNPSRKIL EFLYSTSYNM DRFINK // ID 1XU7D STANDARD; PRT; 286 AA. DT CONVERTED FROM PDB (SEQRES) 1XU7 DE Corticosteroid 11-beta-dehydrogenase, isozyme 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.800 CC R-Factor 0.198 FT #SUB 257 263 TRP D 273 279 LEU B Protein S 1 FT #SUB 269 275 ILE D 257 263 TRP B Protein S 1 FT #SUB 269 275 ILE D 260 266 LEU B Protein S 1 FT #SUB 273 279 LEU D 257 263 TRP B Protein S 3 FT #SUB 90 96 MET D 131 137 ARG C Protein S 1 FT #SUB 122 128 LEU D 194 200 GLU C Protein A 6 FT #SUB 122 128 LEU D 198 204 SER C Protein S 2 FT #SUB 123 129 PHE D 142 148 VAL C Protein S 1 FT #SUB 123 129 PHE D 146 152 VAL C Protein S 2 FT #SUB 123 129 PHE D 187 193 PHE C Protein S 7 FT #SUB 123 129 PHE D 191 197 ILE C Protein S 1 FT #SUB 123 129 PHE D 194 200 GLU C Protein A 5 FT #SUB 125 131 ASP D 146 152 VAL C Protein A 5 FT #SUB 127 133 ILE D 146 152 VAL C Protein S 3 FT #SUB 130 136 VAL D 138 144 PHE C Protein S 2 FT #SUB 130 136 VAL D 187 193 PHE C Protein S 1 FT #SUB 131 137 ARG D 90 96 MET C Protein S 1 FT #SUB 131 137 ARG D 139 145 LEU C Protein S 1 FT #SUB 134 140 MET D 134 140 MET C Protein S 3 FT #SUB 134 140 MET D 138 144 PHE C Protein S 2 FT #SUB 135 141 GLU D 131 137 ARG C Protein S 2 FT #SUB 138 144 PHE D 130 136 VAL C Protein S 2 FT #SUB 138 144 PHE D 134 140 MET C Protein S 2 FT #SUB 138 144 PHE D 179 185 ALA C Protein S 2 FT #SUB 139 145 LEU D 130 136 VAL C Protein S 1 FT #SUB 139 145 LEU D 131 137 ARG C Protein S 3 FT #SUB 142 148 VAL D 123 129 PHE C Protein S 1 FT #SUB 143 149 VAL D 127 133 ILE C Protein S 1 FT #SUB 146 152 VAL D 123 129 PHE C Protein S 2 FT #SUB 146 152 VAL D 125 131 ASP C Protein S 5 FT #SUB 146 152 VAL D 127 133 ILE C Protein S 1 FT #SUB 168 174 LYS D 267 273 ARG C Protein B 1 FT #SUB 169 175 VAL D 267 273 ARG C Protein A 5 FT #SUB 169 175 VAL D 270 276 LEU C Protein S 1 FT #SUB 169 175 VAL D 271 277 GLU C Protein A 3 FT #SUB 170 176 ALA D 189 195 SER C Protein S 3 FT #SUB 170 176 ALA D 190 196 SER C Protein S 1 FT #SUB 170 176 ALA D 193 199 LYS C Protein A 5 FT #SUB 170 176 ALA D 271 277 GLU C Protein A 8 FT #SUB 171 177 TYR D 190 196 SER C Protein B 4 FT #SUB 171 177 TYR D 274 280 TYR C Protein S 9 FT #SUB 172 178 PRO D 190 196 SER C Protein B 1 FT #SUB 172 178 PRO D 193 199 LYS C Protein A 2 FT #SUB 172 178 PRO D 194 200 GLU C Protein A 3 FT #SUB 172 178 PRO D 274 280 TYR C Protein S 2 FT #SUB 173 179 MET D 194 200 GLU C Protein B 5 FT #SUB 174 180 VAL D 194 200 GLU C Protein B 1 FT #SUB 175 181 ALA D 187 193 PHE C Protein A 5 FT #SUB 175 181 ALA D 190 196 SER C Protein A 2 FT #SUB 175 181 ALA D 191 197 ILE C Protein S 1 FT #SUB 178 184 SER D 186 192 GLY C Protein S 4 FT #SUB 178 184 SER D 190 196 SER C Protein S 2 FT #SUB 179 185 ALA D 138 144 PHE C Protein S 2 FT #SUB 179 185 ALA D 183 189 ALA C Protein A 4 FT #SUB 179 185 ALA D 187 193 PHE C Protein S 1 FT #SUB 182 188 PHE D 182 188 PHE C Protein A 8 FT #SUB 182 188 PHE D 185 191 ASP C Protein S 2 FT #SUB 182 188 PHE D 186 192 GLY C Protein S 7 FT #SUB 182 188 PHE D 267 273 ARG C Protein S 2 FT #SUB 183 189 ALA D 179 185 ALA C Protein A 4 FT #SUB 185 191 ASP D 182 188 PHE C Protein S 2 FT #SUB 186 192 GLY D 178 184 SER C Protein B 4 FT #SUB 186 192 GLY D 182 188 PHE C Protein B 7 FT #SUB 187 193 PHE D 123 129 PHE C Protein S 8 FT #SUB 187 193 PHE D 130 136 VAL C Protein S 1 FT #SUB 187 193 PHE D 175 181 ALA C Protein A 5 FT #SUB 187 193 PHE D 179 185 ALA C Protein S 1 FT #SUB 189 195 SER D 170 176 ALA C Protein A 3 FT #SUB 190 196 SER D 170 176 ALA C Protein B 1 FT #SUB 190 196 SER D 171 177 TYR C Protein A 4 FT #SUB 190 196 SER D 172 178 PRO C Protein B 1 FT #SUB 190 196 SER D 174 180 VAL C Protein S 1 FT #SUB 190 196 SER D 175 181 ALA C Protein S 5 FT #SUB 191 197 ILE D 123 129 PHE C Protein S 1 FT #SUB 191 197 ILE D 175 181 ALA C Protein S 1 FT #SUB 193 199 LYS D 170 176 ALA C Protein S 5 FT #SUB 193 199 LYS D 172 178 PRO C Protein S 1 FT #SUB 194 200 GLU D 121 127 ASN C Protein S 1 FT #SUB 194 200 GLU D 122 128 LEU C Protein S 7 FT #SUB 194 200 GLU D 123 129 PHE C Protein S 5 FT #SUB 194 200 GLU D 172 178 PRO C Protein S 3 FT #SUB 194 200 GLU D 173 179 MET C Protein S 5 FT #SUB 198 204 SER D 122 128 LEU C Protein S 2 FT #SUB 225 231 VAL D 274 280 TYR C Protein S 1 FT #SUB 227 233 MET D 274 280 TYR C Protein S 1 FT #SUB 261 267 LEU D 266 272 SER C Protein A 6 FT #SUB 261 267 LEU D 269 275 ILE C Protein S 2 FT #SUB 261 267 LEU D 270 276 LEU C Protein A 6 FT #SUB 264 270 ASN D 264 270 ASN C Protein S 3 FT #SUB 266 272 SER D 261 267 LEU C Protein A 6 FT #SUB 267 273 ARG D 168 174 LYS C Protein S 1 FT #SUB 267 273 ARG D 169 175 VAL C Protein A 5 FT #SUB 267 273 ARG D 182 188 PHE C Protein S 2 FT #SUB 269 275 ILE D 261 267 LEU C Protein S 2 FT #SUB 270 276 LEU D 261 267 LEU C Protein S 1 FT #SUB 271 277 GLU D 169 175 VAL C Protein S 3 FT #SUB 271 277 GLU D 170 176 ALA C Protein S 8 FT #SUB 274 280 TYR D 171 177 TYR C Protein S 6 FT #SUB 274 280 TYR D 172 178 PRO C Protein S 2 FT #SUB 274 280 TYR D 225 231 VAL C Protein S 1 FT #SUB 274 280 TYR D 227 233 MET C Protein S 2 FT #HET 35 41 GLY D 9 528 NDP D B 8 FT #HET 36 42 ALA D 9 528 NDP D B 1 FT #HET 37 43 SER D 9 528 NDP D A 8 FT #HET 38 44 LYS D 9 528 NDP D A 10 FT #HET 39 45 GLY D 9 528 NDP D B 4 FT #HET 40 46 ILE D 9 528 NDP D A 10 FT #HET 59 65 ALA D 9 528 NDP D S 3 FT #HET 60 66 ARG D 9 528 NDP D A 28 FT #HET 61 67 SER D 9 528 NDP D A 2 FT #HET 85 91 GLY D 9 528 NDP D B 1 FT #HET 86 92 THR D 9 528 NDP D A 5 FT #HET 87 93 MET D 9 528 NDP D A 9 FT #HET 113 119 ASN D 9 528 NDP D A 10 FT #HET 114 120 HIS D 9 528 NDP D A 3 FT #HET 115 121 ILE D 9 528 NDP D A 13 FT #HET 115 121 ILE D 10 529 CPS D S 3 FT #HET 118 124 THR D 10 529 CPS D S 1 FT #HET 120 126 LEU D 10 529 CPS D S 2 FT #HET 162 168 VAL D 9 528 NDP D A 5 FT #HET 163 169 SER D 9 528 NDP D B 1 FT #HET 164 170 SER D 9 528 NDP D A 6 FT #HET 165 171 LEU D 10 529 CPS D S 5 FT #HET 166 172 ALA D 10 529 CPS D S 1 FT #HET 171 177 TYR D 10 529 CPS D S 9 FT #HET 177 183 TYR D 9 528 NDP D S 7 FT #HET 177 183 TYR D 10 529 CPS D S 17 FT #HET 181 187 LYS D 9 528 NDP D S 4 FT #HET 209 215 LEU D 9 528 NDP D A 3 FT #HET 210 216 GLY D 9 528 NDP D B 4 FT #HET 211 217 LEU D 9 528 NDP D A 3 FT #HET 211 217 LEU D 10 529 CPS D A 4 FT #HET 212 218 ILE D 9 528 NDP D A 10 FT #HET 214 220 THR D 9 528 NDP D S 8 FT #HET 216 222 THR D 9 528 NDP D S 6 FT #HET 217 223 ALA D 9 528 NDP D S 3 FT #HET 217 223 ALA D 10 529 CPS D A 3 FT #HET 220 226 ALA D 10 529 CPS D S 1 FT #HET 221 227 VAL D 10 529 CPS D S 2 FT #HET 225 231 VAL D 10 529 CPS D S 1 FT #HET 227 233 MET D 10 529 CPS D A 6 FT #HET 228 234 GLN D 10 529 CPS D A 4 FT #HET 253 259 ASP D 10 529 CPS D S 1 FT #HET 258 264 THR D 10 529 CPS D S 3 FT #HET 261 267 LEU D 8 2 CPS C S 1 FT #HET 265 271 PRO D 8 2 CPS C S 1 FT #HET 266 272 SER D 3 1 CPS A S 2 FT #HET 273 279 LEU D 7 527 CPS C S 2 FT #HET 274 280 TYR D 7 527 CPS C S 3 FT DISORDER 1 14 FT DISORDER 276 286 CC SEQUENCE 261 AA (ATOM); CC QPLNEEFRPE MLQGKKVIVT GASKGIGREM AYHLAKMGAH VVVTARSKET LQKVVSHCLE CC LGAASAHYIA GTMEDMTFAE QFVAQAGKLM GGLDMLILNH ITNTSLNLFH DDIHHVRKSM CC EVNFLSYVVL TVAALPMLKQ SNGSIVVVSS LAGKVAYPMV AAYSASKFAL DGFFSSIRKE CC YSVSRVNVSI TLCVLGLIDT ETAMKAVSGI VHMQAAPKEE CALEIIKGGA LRQEEVYYDS CC SLWTTLLIRN PSRKILEFLY S CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MKHQHQHQHQHQHQQPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ATOM --------------QPLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAK CC ************************************ CC SEQRES MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ATOM MGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQA CC ************************************************** CC SEQRES GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ATOM GKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP CC ************************************************** CC SEQRES MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ATOM MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRV CC ************************************************** CC SEQRES NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ATOM NVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEV CC ************************************************** CC SEQRES YYDSSLWTTLLIRNPSRKILEFLYSTSYNMDRFINK CC ATOM YYDSSLWTTLLIRNPSRKILEFLYS----------- CC ************************* SQ SEQUENCE 286 AA; MW; CN; MKHQHQHQHQ HQHQQPLNEE FRPEMLQGKK VIVTGASKGI GREMAYHLAK MGAHVVVTAR SKETLQKVVS HCLELGAASA HYIAGTMEDM TFAEQFVAQA GKLMGGLDML ILNHITNTSL NLFHDDIHHV RKSMEVNFLS YVVLTVAALP MLKQSNGSIV VVSSLAGKVA YPMVAAYSAS KFALDGFFSS IRKEYSVSRV NVSITLCVLG LIDTETAMKA VSGIVHMQAA PKEECALEII KGGALRQEEV YYDSSLWTTL LIRNPSRKIL EFLYSTSYNM DRFINK //