Brand  (β version)

PDB ID: 1VKG

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Ligands
Code Name Style Show Link
CRI 5-(4-methyl-benzoylamino)-biphenyl-3,4'-dicarboxylic acid 3-dimethylamide-4'-hydroxyamide PoSSuM
NA Sodium ion PoSSuM
ZN Zinc ion PoSSuM
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Structure summary

Code : 1VKG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of Human HDAC8 complexed with CRA-19156
Release Data : 2004-07-27
Compound :
mol_id molecule chains synonym
1 Histone deacetylase 8 A,B HDAC8
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: HDAC8, HDACL1
expression_system_common: Fall armyworm
expression_system_strain: Sf9
expression_system_vector_type: baculovirus
expression_system_vector: pSXB2
expression_system_plasmid: pFastbacHTa
Authors : Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Keywords : histone deacetylase, zinc hydrolase, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

Somoza, J.R.,Skene, R.J.,Katz, B.A.  et al.
(2004)  Structure  12 : 1325 - 1334

PubMed: 15242608
DOI: 10.1016/j.str.2004.04.012

Reaction

Chain : A, B
UniProt : Q9BY41 (HDAC8_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate 3.5.1.98 PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:28497810
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N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate - PubMed:22885700
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N(6)-(2E)-butenoyl-L-lysyl-[protein] + H2O = (2E)-2-butenoate + L-lysyl-[protein] - PubMed:28497810
left-to-right
Cofactor: Evidence: Note:
a divalent metal cation ECO:0000269 | PubMed:15242608
Binds 1 divalent metal cation per subunit.