PDB ID: 1SEJ
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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UMP | 2'-deoxyuridine 5'-monophosphate | PoSSuM | |||
F89 | S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo(f)quinazolin-9-yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid | PoSSuM | |||
NDP | Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate | PoSSuM |
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Download interaction data: 1SEJ
Structure summary
Code : | 1SEJ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE, OXIDOREDUCTASE | ||||||||||||
Title : | Crystal Structure of Dihydrofolate Reductase-Thymidylate Synthase from Cryptosporidium hominis Bound to 1843U89/NADPH/dUMP | ||||||||||||
Release Data : | 2004-05-18 | ||||||||||||
Compound : |
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Authors : | Anderson, A.C. | ||||||||||||
Keywords : | bifunctional enzyme, TRANSFERASE, OXIDOREDUCTASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.87 Å ) | ||||||||||||
Citation : |
Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance.
Anderson, A.C.
PubMed: 16511011 |
Reaction
Chain : | A, B, C, D, E | ||||||||||||
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UniProt : | Q27552 (Q27552_CRYPV) | ||||||||||||
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