Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
F89 S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo(f)quinazolin-9-yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
UMP 2'-deoxyuridine 5'-monophosphate
Code : 1SEJ
Header : TRANSFERASE, OXIDOREDUCTASE
Title : Crystal Structure of Dihydrofolate Reductase-Thymidylate Synthase from Cryptosporidium hominis Bound to 1843U89/NADPH/dUMP
Release Data : 2004-05-18
Compound :
mol_id molecule chains
1 bifunctional dihydrofolate reductase-thymidylate synthase A,B,C,D,E
ec: 2.1.1.45, 1.5.1.3
Source :
mol_id organism_scientific expression_system
1 Cryptosporidium hominis  (taxid:237895) Escherichia coli  (taxid:562)
expression_system_strain: PA414
Authors : Anderson, A.C.
Keywords : bifunctional enzyme, TRANSFERASE, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.87 Å )
Citation :

Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance.

Anderson, A.C.
(2005)  Acta Crystallogr.,Sect.F  61 : 258 - 262

PubMed: 16511011
DOI: 10.1107/S1744309105002435

Chain : A, B, C, D, E
UniProt : Q27552 (No found in current UniProtKB/SwissProt)
Reaction : -