ID 1SEJA STANDARD; PRT; 521 AA. DT CONVERTED FROM PDB (SEQRES) 1SEJ DE bifunctional dihydrofolate reductase-thymidylate synthase OS Cryptosporidium hominis CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.870 CC R-Factor 0.220 FT #SUB 31 31 GLU A 206 206 ILE B Protein A 5 FT #SUB 31 31 GLU A 207 207 PHE B Protein S 4 FT #SUB 31 31 GLU A 210 210 ARG B Protein S 5 FT #SUB 34 34 LYS A 206 206 ILE B Protein A 3 FT #SUB 35 35 PHE A 199 199 THR B Protein S 2 FT #SUB 35 35 PHE A 203 203 LEU B Protein S 2 FT #SUB 35 35 PHE A 206 206 ILE B Protein A 4 FT #SUB 38 38 LYS A 202 202 LEU B Protein A 4 FT #SUB 38 38 LYS A 205 205 GLU B Protein S 4 FT #SUB 38 38 LYS A 206 206 ILE B Protein S 2 FT #SUB 39 39 ILE A 202 202 LEU B Protein A 3 FT #SUB 42 42 ASN A 198 198 ASP B Protein S 3 FT #SUB 44 44 CYS A 194 194 LYS B Protein S 1 FT #SUB 130 130 ARG A 195 195 SER B Protein S 3 FT #SUB 132 132 TYR A 199 199 THR B Protein S 2 FT #SUB 157 157 VAL A 196 196 ILE B Protein B 1 FT #SUB 158 158 TYR A 196 196 ILE B Protein S 2 FT #SUB 158 158 TYR A 200 200 VAL B Protein S 3 FT #SUB 158 158 TYR A 203 203 LEU B Protein S 1 FT #SUB 161 161 GLN A 210 210 ARG B Protein S 1 FT #SUB 161 161 GLN A 211 211 LYS B Protein S 3 FT #SUB 161 161 GLN A 212 212 MET B Protein S 5 FT #SUB 163 163 PHE A 207 207 PHE B Protein S 17 FT #SUB 163 163 PHE A 211 211 LYS B Protein S 3 FT #SUB 164 164 CYS A 210 210 ARG B Protein B 1 FT #SUB 170 170 TYR A 207 207 PHE B Protein S 4 FT #SUB 172 172 PHE A 203 203 LEU B Protein S 10 FT #SUB 172 172 PHE A 207 207 PHE B Protein S 1 FT #SUB 174 174 ILE A 195 195 SER B Protein S 2 FT #SUB 174 174 ILE A 199 199 THR B Protein S 2 FT #SUB 176 176 GLU A 193 193 LEU B Protein S 2 FT #SUB 176 176 GLU A 195 195 SER B Protein S 4 FT #SUB 192 192 GLN A 192 192 GLN B Protein S 4 FT #SUB 192 192 GLN A 231 231 PHE B Protein S 12 FT #SUB 193 193 LEU A 176 176 GLU B Protein S 1 FT #SUB 194 194 LYS A 44 44 CYS B Protein S 1 FT #SUB 195 195 SER A 130 130 ARG B Protein S 3 FT #SUB 195 195 SER A 174 174 ILE B Protein B 2 FT #SUB 195 195 SER A 176 176 GLU B Protein S 4 FT #SUB 196 196 ILE A 157 157 VAL B Protein S 1 FT #SUB 196 196 ILE A 158 158 TYR B Protein S 3 FT #SUB 198 198 ASP A 42 42 ASN B Protein S 3 FT #SUB 199 199 THR A 35 35 PHE B Protein S 2 FT #SUB 199 199 THR A 132 132 TYR B Protein S 1 FT #SUB 199 199 THR A 174 174 ILE B Protein S 2 FT #SUB 200 200 VAL A 158 158 TYR B Protein S 3 FT #SUB 200 200 VAL A 234 234 GLU B Protein S 1 FT #SUB 202 202 LEU A 38 38 LYS B Protein S 4 FT #SUB 202 202 LEU A 39 39 ILE B Protein S 3 FT #SUB 203 203 LEU A 35 35 PHE B Protein S 2 FT #SUB 203 203 LEU A 158 158 TYR B Protein S 1 FT #SUB 203 203 LEU A 172 172 PHE B Protein S 10 FT #SUB 205 205 GLU A 38 38 LYS B Protein S 4 FT #SUB 206 206 ILE A 31 31 GLU B Protein S 5 FT #SUB 206 206 ILE A 34 34 LYS B Protein S 3 FT #SUB 206 206 ILE A 35 35 PHE B Protein S 3 FT #SUB 206 206 ILE A 38 38 LYS B Protein S 1 FT #SUB 207 207 PHE A 31 31 GLU B Protein S 4 FT #SUB 207 207 PHE A 163 163 PHE B Protein S 17 FT #SUB 207 207 PHE A 170 170 TYR B Protein S 4 FT #SUB 207 207 PHE A 172 172 PHE B Protein S 1 FT #SUB 209 209 ILE A 275 275 ARG B Protein A 2 FT #SUB 210 210 ARG A 31 31 GLU B Protein S 5 FT #SUB 210 210 ARG A 161 161 GLN B Protein B 1 FT #SUB 210 210 ARG A 164 164 CYS B Protein S 1 FT #SUB 210 210 ARG A 276 276 GLU B Protein A 12 FT #SUB 211 211 LYS A 161 161 GLN B Protein A 3 FT #SUB 211 211 LYS A 163 163 PHE B Protein A 3 FT #SUB 211 211 LYS A 234 234 GLU B Protein S 4 FT #SUB 212 212 MET A 161 161 GLN B Protein A 5 FT #SUB 212 212 MET A 236 236 TYR B Protein S 8 FT #SUB 212 212 MET A 271 271 ARG B Protein S 1 FT #SUB 212 212 MET A 273 273 ASP B Protein S 3 FT #SUB 212 212 MET A 455 455 GLU B Protein S 6 FT #SUB 215 215 ARG A 273 273 ASP B Protein S 5 FT #SUB 215 215 ARG A 275 275 ARG B Protein S 19 FT #SUB 215 215 ARG A 455 455 GLU B Protein S 5 FT #SUB 216 216 HIS A 271 271 ARG B Protein S 1 FT #SUB 216 216 HIS A 455 455 GLU B Protein S 4 FT #SUB 231 231 PHE A 192 192 GLN B Protein S 10 FT #SUB 234 234 GLU A 200 200 VAL B Protein S 1 FT #SUB 234 234 GLU A 211 211 LYS B Protein S 4 FT #SUB 236 236 TYR A 212 212 MET B Protein S 8 FT #SUB 252 252 ALA A 412 412 ASN B Protein S 1 FT #SUB 253 253 TYR A 412 412 ASN B Protein B 2 FT #SUB 254 254 ARG A 380 380 LYS B Protein S 9 FT #SUB 254 254 ARG A 409 409 TYR B Protein S 12 FT #SUB 254 254 ARG A 410 410 VAL B Protein S 4 FT #SUB 254 254 ARG A 411 411 THR B Protein S 3 FT #SUB 254 254 ARG A 412 412 ASN B Protein S 4 FT #SUB 255 255 GLU A 380 380 LYS B Protein A 2 FT #SUB 256 256 ASN A 382 382 ARG B Protein S 6 FT #SUB 264 264 SER A 409 409 TYR B Protein A 6 FT #SUB 266 266 PHE A 407 407 GLN B Protein S 7 FT #SUB 266 266 PHE A 409 409 TYR B Protein S 18 FT #SUB 266 266 PHE A 417 417 SER B Protein S 1 FT #SUB 266 266 PHE A 418 418 CYS B Protein S 1 FT #SUB 266 266 PHE A 419 419 ASN B Protein S 11 FT #SUB 267 267 GLY A 271 271 ARG B Protein B 3 FT #SUB 267 267 GLY A 419 419 ASN B Protein B 4 FT #SUB 268 268 GLN A 271 271 ARG B Protein S 2 FT #SUB 269 269 MET A 269 269 MET B Protein S 5 FT #SUB 271 271 ARG A 212 212 MET B Protein S 1 FT #SUB 271 271 ARG A 216 216 HIS B Protein S 1 FT #SUB 271 271 ARG A 267 267 GLY B Protein S 3 FT #SUB 271 271 ARG A 268 268 GLN B Protein S 2 FT #SUB 273 273 ASP A 212 212 MET B Protein A 3 FT #SUB 273 273 ASP A 215 215 ARG B Protein S 5 FT #SUB 275 275 ARG A 209 209 ILE B Protein S 1 FT #SUB 275 275 ARG A 215 215 ARG B Protein S 16 FT #SUB 276 276 GLU A 210 210 ARG B Protein S 12 FT #SUB 349 349 TYR A 349 349 TYR B Protein S 5 FT #SUB 349 349 TYR A 391 391 PRO B Protein S 7 FT #SUB 350 350 ASN A 350 350 ASN B Protein S 8 FT #SUB 350 350 ASN A 390 390 ASN B Protein S 1 FT #SUB 350 350 ASN A 392 392 SER B Protein S 4 FT #SUB 365 365 VAL A 392 392 SER B Protein S 1 FT #SUB 367 367 GLN A 391 391 PRO B Protein S 2 FT #SUB 380 380 LYS A 254 254 ARG B Protein A 8 FT #SUB 380 380 LYS A 255 255 GLU B Protein S 2 FT #SUB 382 382 ARG A 256 256 ASN B Protein S 6 FT #SUB 382 382 ARG A 423 423 ARG B Protein A 6 FT #SUB 382 382 ARG A 424 424 SER B Protein S 3 FT #SUB 382 382 ARG A 462 462 ASP B Protein S 3 FT #SUB 382 382 ARG A 464 464 HIS B Protein S 8 FT #SUB 382 382 ARG A 466 466 TYR B Protein S 3 FT #SUB 383 383 ARG A 400 400 PRO B Protein S 8 FT #SUB 383 383 ARG A 423 423 ARG B Protein S 6 FT #SUB 385 385 ILE A 389 389 TRP B Protein S 6 FT #SUB 385 385 ILE A 423 423 ARG B Protein S 2 FT #SUB 387 387 THR A 389 389 TRP B Protein S 1 FT #SUB 387 387 THR A 391 391 PRO B Protein S 1 FT #SUB 389 389 TRP A 385 385 ILE B Protein S 6 FT #SUB 389 389 TRP A 387 387 THR B Protein S 1 FT #SUB 390 390 ASN A 350 350 ASN B Protein S 1 FT #SUB 391 391 PRO A 349 349 TYR B Protein S 7 FT #SUB 391 391 PRO A 367 367 GLN B Protein S 2 FT #SUB 391 391 PRO A 387 387 THR B Protein S 1 FT #SUB 392 392 SER A 350 350 ASN B Protein S 4 FT #SUB 392 392 SER A 365 365 VAL B Protein S 1 FT #SUB 400 400 PRO A 383 383 ARG B Protein S 7 FT #SUB 404 404 VAL A 405 405 LEU B Protein S 1 FT #SUB 405 405 LEU A 404 404 VAL B Protein S 1 FT #SUB 405 405 LEU A 421 421 TYR B Protein S 1 FT #SUB 407 407 GLN A 266 266 PHE B Protein A 6 FT #SUB 407 407 GLN A 421 421 TYR B Protein S 5 FT #SUB 407 407 GLN A 423 423 ARG B Protein S 11 FT #SUB 407 407 GLN A 461 461 GLY B Protein S 1 FT #SUB 409 409 TYR A 254 254 ARG B Protein S 12 FT #SUB 409 409 TYR A 264 264 SER B Protein S 6 FT #SUB 409 409 TYR A 266 266 PHE B Protein S 18 FT #SUB 409 409 TYR A 462 462 ASP B Protein S 2 FT #SUB 410 410 VAL A 254 254 ARG B Protein B 4 FT #SUB 411 411 THR A 254 254 ARG B Protein B 3 FT #SUB 412 412 ASN A 252 252 ALA B Protein S 1 FT #SUB 412 412 ASN A 253 253 TYR B Protein S 2 FT #SUB 412 412 ASN A 254 254 ARG B Protein A 4 FT #SUB 417 417 SER A 266 266 PHE B Protein S 1 FT #SUB 418 418 CYS A 266 266 PHE B Protein B 1 FT #SUB 419 419 ASN A 266 266 PHE B Protein A 11 FT #SUB 419 419 ASN A 267 267 GLY B Protein S 4 FT #SUB 419 419 ASN A 421 421 TYR B Protein S 4 FT #SUB 419 419 ASN A 460 460 ILE B Protein S 1 FT #SUB 419 419 ASN A 461 461 GLY B Protein S 1 FT #SUB 421 421 TYR A 405 405 LEU B Protein S 2 FT #SUB 421 421 TYR A 407 407 GLN B Protein S 6 FT #SUB 421 421 TYR A 419 419 ASN B Protein S 3 FT #SUB 421 421 TYR A 459 459 PHE B Protein S 2 FT #SUB 423 423 ARG A 382 382 ARG B Protein S 6 FT #SUB 423 423 ARG A 383 383 ARG B Protein S 6 FT #SUB 423 423 ARG A 385 385 ILE B Protein S 3 FT #SUB 423 423 ARG A 407 407 GLN B Protein A 11 FT #SUB 424 424 SER A 382 382 ARG B Protein S 3 FT #SUB 455 455 GLU A 212 212 MET B Protein S 6 FT #SUB 455 455 GLU A 215 215 ARG B Protein S 5 FT #SUB 455 455 GLU A 216 216 HIS B Protein S 4 FT #SUB 459 459 PHE A 421 421 TYR B Protein S 2 FT #SUB 459 459 PHE A 459 459 PHE B Protein S 12 FT #SUB 460 460 ILE A 419 419 ASN B Protein B 1 FT #SUB 461 461 GLY A 407 407 GLN B Protein B 1 FT #SUB 461 461 GLY A 419 419 ASN B Protein B 1 FT #SUB 462 462 ASP A 382 382 ARG B Protein S 4 FT #SUB 462 462 ASP A 409 409 TYR B Protein S 2 FT #SUB 464 464 HIS A 382 382 ARG B Protein S 8 FT #SUB 466 466 TYR A 382 382 ARG B Protein S 3 FT #HET 9 9 VAL A 3 605 F89 A A 6 FT #HET 10 10 VAL A 3 605 F89 A B 9 FT #HET 10 10 VAL A 4 606 NDP A A 5 FT #HET 11 11 ALA A 3 605 F89 A A 6 FT #HET 11 11 ALA A 4 606 NDP A A 9 FT #HET 19 19 ILE A 4 606 NDP A A 14 FT #HET 20 20 GLY A 4 606 NDP A B 2 FT #HET 21 21 ILE A 4 606 NDP A B 1 FT #HET 23 23 GLY A 4 606 NDP A B 6 FT #HET 24 24 GLN A 4 606 NDP A B 7 FT #HET 25 25 LEU A 3 605 F89 A S 5 FT #HET 25 25 LEU A 4 606 NDP A A 6 FT #HET 32 32 ASP A 3 605 F89 A S 8 FT #HET 33 33 LEU A 3 605 F89 A A 9 FT #HET 34 34 LYS A 3 605 F89 A S 1 FT #HET 36 36 PHE A 3 605 F89 A S 10 FT #HET 37 37 SER A 3 605 F89 A S 8 FT #HET 55 55 GLY A 4 606 NDP A B 10 FT #HET 56 56 ARG A 4 606 NDP A A 15 FT #HET 57 57 LYS A 4 606 NDP A A 16 FT #HET 58 58 THR A 4 606 NDP A A 9 FT #HET 61 61 SER A 4 606 NDP A S 1 FT #HET 62 62 ILE A 3 605 F89 A S 5 FT #HET 67 67 LEU A 3 605 F89 A S 3 FT #HET 70 70 ARG A 3 605 F89 A S 8 FT #HET 75 75 ILE A 4 606 NDP A A 9 FT #HET 76 76 SER A 4 606 NDP A A 8 FT #HET 77 77 SER A 4 606 NDP A A 7 FT #HET 78 78 SER A 4 606 NDP A A 2 FT #HET 92 92 ARG A 4 606 NDP A B 3 FT #HET 113 113 CYS A 3 605 F89 A B 2 FT #HET 113 113 CYS A 4 606 NDP A B 2 FT #HET 114 114 GLY A 4 606 NDP A B 2 FT #HET 115 115 GLY A 4 606 NDP A B 13 FT #HET 116 116 GLU A 4 606 NDP A A 6 FT #HET 117 117 SER A 4 606 NDP A A 8 FT #HET 118 118 ILE A 4 606 NDP A A 4 FT #HET 119 119 TYR A 3 605 F89 A S 1 FT #HET 119 119 TYR A 4 606 NDP A S 2 FT #HET 121 121 ASP A 4 606 NDP A S 1 FT #HET 134 134 THR A 3 605 F89 A S 2 FT #HET 145 145 THR A 4 606 NDP A S 5 FT #HET 257 257 ARG A 1 603 UMP A S 11 FT #HET 290 290 SER A 2 604 F89 A S 2 FT #HET 294 294 GLU A 2 604 F89 A S 2 FT #HET 315 315 ILE A 2 604 F89 A S 16 FT #HET 316 316 TRP A 2 604 F89 A S 3 FT #HET 319 319 ASN A 2 604 F89 A S 1 FT #HET 382 382 ARG A 5 607 UMP B S 11 FT #HET 383 383 ARG A 5 607 UMP B S 5 FT #HET 399 399 LEU A 1 603 UMP A S 1 FT #HET 399 399 LEU A 2 604 F89 A S 1 FT #HET 402 402 CYS A 1 603 UMP A S 5 FT #HET 403 403 HIS A 1 603 UMP A S 1 FT #HET 422 422 GLN A 1 603 UMP A S 3 FT #HET 423 423 ARG A 1 603 UMP A S 6 FT #HET 424 424 SER A 1 603 UMP A A 6 FT #HET 425 425 CYS A 1 603 UMP A B 2 FT #HET 426 426 ASP A 1 603 UMP A A 7 FT #HET 426 426 ASP A 2 604 F89 A S 8 FT #HET 429 429 LEU A 2 604 F89 A S 1 FT #HET 430 430 GLY A 2 604 F89 A B 2 FT #HET 433 433 PHE A 2 604 F89 A S 29 FT #HET 434 434 ASN A 1 603 UMP A S 8 FT #HET 464 464 HIS A 1 603 UMP A S 5 FT #HET 466 466 TYR A 1 603 UMP A S 5 FT #HET 466 466 TYR A 2 604 F89 A S 3 FT #HET 519 519 MET A 2 604 F89 A S 6 FT #HET 520 520 ALA A 2 604 F89 A B 2 FT DISORDER 1 2 CC SEQUENCE 519 AA (ATOM); CC EKNVSIVVAA SVLSSGIGIN GQLPWSISED LKFFSKITNN KCDSNKKNAL IMGRKTWDSI CC GRRPLKNRII VVISSSLPQD EADPNVVVFR NLEDSIENLM NDDSIENIFV CGGESIYRDA CC LKDNFVDRIY LTRVALEDIE FDTYFPEIPE TFLPVYMSQT FCTKNISYDF MIFEKQEKKT CC LQNCDPARGQ LKSIDDTVDL LGEIFGIRKM GNRHKFPKEE IYNTPSIRFG REHYEFQYLD CC LLSRVLENGA YRENRTGIST YSIFGQMMRF DMRESFPLLT TKKVAIRSIF EELIWFIKGD CC TNGNHLIEKK VYIWSGNGSK EYLERIGLGH REENDLGPIY GFQWRHYNGE YKTMHDDYTG CC VGVDQLAKLI ETLKNNPKDR RHILTAWNPS ALSQMALPPC HVLSQYYVTN DNCLSCNLYQ CC RSCDLGLGSP FNIASYAILT MMLAQVCGYE PGELAIFIGD AHIYENHLTQ LKEQLSRTPR CC PFPQLKFKRK VENIEDFKWE DIELIGYYPY PTIKMDMAV CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSEKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKN CC ATOM --EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKN CC ************************************************ CC SEQRES ALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIEN CC ATOM ALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIEN CC ************************************************** CC SEQRES LMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEI CC ATOM LMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEI CC ************************************************** CC SEQRES PETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTV CC ATOM PETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTV CC ************************************************** CC SEQRES DLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLEN CC ATOM DLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLEN CC ************************************************** CC SEQRES GAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK CC ATOM GAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK CC ************************************************** CC SEQRES GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYN CC ATOM GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYN CC ************************************************** CC SEQRES GEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALP CC ATOM GEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALP CC ************************************************** CC SEQRES PCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCG CC ATOM PCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCG CC ************************************************** CC SEQRES YEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFK CC ATOM YEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFK CC ************************************************** CC SEQRES WEDIELIGYYPYPTIKMDMAV CC ATOM WEDIELIGYYPYPTIKMDMAV CC ********************* SQ SEQUENCE 521 AA; MW; CN; MSEKNVSIVV AASVLSSGIG INGQLPWSIS EDLKFFSKIT NNKCDSNKKN ALIMGRKTWD SIGRRPLKNR IIVVISSSLP QDEADPNVVV FRNLEDSIEN LMNDDSIENI FVCGGESIYR DALKDNFVDR IYLTRVALED IEFDTYFPEI PETFLPVYMS QTFCTKNISY DFMIFEKQEK KTLQNCDPAR GQLKSIDDTV DLLGEIFGIR KMGNRHKFPK EEIYNTPSIR FGREHYEFQY LDLLSRVLEN GAYRENRTGI STYSIFGQMM RFDMRESFPL LTTKKVAIRS IFEELIWFIK GDTNGNHLIE KKVYIWSGNG SKEYLERIGL GHREENDLGP IYGFQWRHYN GEYKTMHDDY TGVGVDQLAK LIETLKNNPK DRRHILTAWN PSALSQMALP PCHVLSQYYV TNDNCLSCNL YQRSCDLGLG SPFNIASYAI LTMMLAQVCG YEPGELAIFI GDAHIYENHL TQLKEQLSRT PRPFPQLKFK RKVENIEDFK WEDIELIGYY PYPTIKMDMA V // ID 1SEJB STANDARD; PRT; 521 AA. DT CONVERTED FROM PDB (SEQRES) 1SEJ DE bifunctional dihydrofolate reductase-thymidylate synthase OS Cryptosporidium hominis CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.870 CC R-Factor 0.220 FT #SUB 31 31 GLU B 206 206 ILE A Protein A 5 FT #SUB 31 31 GLU B 207 207 PHE A Protein S 4 FT #SUB 31 31 GLU B 210 210 ARG A Protein S 5 FT #SUB 34 34 LYS B 206 206 ILE A Protein A 3 FT #SUB 35 35 PHE B 199 199 THR A Protein S 2 FT #SUB 35 35 PHE B 203 203 LEU A Protein S 2 FT #SUB 35 35 PHE B 206 206 ILE A Protein A 3 FT #SUB 38 38 LYS B 202 202 LEU A Protein A 4 FT #SUB 38 38 LYS B 205 205 GLU A Protein S 4 FT #SUB 38 38 LYS B 206 206 ILE A Protein S 1 FT #SUB 39 39 ILE B 202 202 LEU A Protein A 3 FT #SUB 42 42 ASN B 198 198 ASP A Protein S 3 FT #SUB 44 44 CYS B 194 194 LYS A Protein S 1 FT #SUB 130 130 ARG B 195 195 SER A Protein S 3 FT #SUB 132 132 TYR B 199 199 THR A Protein S 1 FT #SUB 157 157 VAL B 196 196 ILE A Protein B 1 FT #SUB 158 158 TYR B 196 196 ILE A Protein S 3 FT #SUB 158 158 TYR B 200 200 VAL A Protein S 3 FT #SUB 158 158 TYR B 203 203 LEU A Protein S 1 FT #SUB 161 161 GLN B 210 210 ARG A Protein S 1 FT #SUB 161 161 GLN B 211 211 LYS A Protein S 3 FT #SUB 161 161 GLN B 212 212 MET A Protein S 5 FT #SUB 163 163 PHE B 207 207 PHE A Protein S 17 FT #SUB 163 163 PHE B 211 211 LYS A Protein S 3 FT #SUB 164 164 CYS B 210 210 ARG A Protein B 1 FT #SUB 170 170 TYR B 207 207 PHE A Protein S 4 FT #SUB 172 172 PHE B 203 203 LEU A Protein S 10 FT #SUB 172 172 PHE B 207 207 PHE A Protein S 1 FT #SUB 174 174 ILE B 195 195 SER A Protein S 2 FT #SUB 174 174 ILE B 199 199 THR A Protein S 2 FT #SUB 176 176 GLU B 193 193 LEU A Protein S 1 FT #SUB 176 176 GLU B 195 195 SER A Protein S 4 FT #SUB 192 192 GLN B 192 192 GLN A Protein S 4 FT #SUB 192 192 GLN B 231 231 PHE A Protein S 10 FT #SUB 193 193 LEU B 176 176 GLU A Protein S 2 FT #SUB 194 194 LYS B 44 44 CYS A Protein S 1 FT #SUB 195 195 SER B 130 130 ARG A Protein S 3 FT #SUB 195 195 SER B 174 174 ILE A Protein B 2 FT #SUB 195 195 SER B 176 176 GLU A Protein S 4 FT #SUB 196 196 ILE B 157 157 VAL A Protein S 1 FT #SUB 196 196 ILE B 158 158 TYR A Protein S 2 FT #SUB 198 198 ASP B 42 42 ASN A Protein S 3 FT #SUB 199 199 THR B 35 35 PHE A Protein S 2 FT #SUB 199 199 THR B 132 132 TYR A Protein S 2 FT #SUB 199 199 THR B 174 174 ILE A Protein S 2 FT #SUB 200 200 VAL B 158 158 TYR A Protein S 3 FT #SUB 200 200 VAL B 234 234 GLU A Protein S 1 FT #SUB 202 202 LEU B 38 38 LYS A Protein S 4 FT #SUB 202 202 LEU B 39 39 ILE A Protein S 3 FT #SUB 203 203 LEU B 35 35 PHE A Protein S 2 FT #SUB 203 203 LEU B 158 158 TYR A Protein S 1 FT #SUB 203 203 LEU B 172 172 PHE A Protein S 10 FT #SUB 205 205 GLU B 38 38 LYS A Protein S 4 FT #SUB 206 206 ILE B 31 31 GLU A Protein S 5 FT #SUB 206 206 ILE B 34 34 LYS A Protein S 3 FT #SUB 206 206 ILE B 35 35 PHE A Protein S 4 FT #SUB 206 206 ILE B 38 38 LYS A Protein A 2 FT #SUB 207 207 PHE B 31 31 GLU A Protein S 4 FT #SUB 207 207 PHE B 163 163 PHE A Protein S 17 FT #SUB 207 207 PHE B 170 170 TYR A Protein S 4 FT #SUB 207 207 PHE B 172 172 PHE A Protein S 1 FT #SUB 209 209 ILE B 275 275 ARG A Protein S 1 FT #SUB 210 210 ARG B 31 31 GLU A Protein S 5 FT #SUB 210 210 ARG B 161 161 GLN A Protein B 1 FT #SUB 210 210 ARG B 164 164 CYS A Protein S 1 FT #SUB 210 210 ARG B 276 276 GLU A Protein A 12 FT #SUB 211 211 LYS B 161 161 GLN A Protein A 3 FT #SUB 211 211 LYS B 163 163 PHE A Protein A 3 FT #SUB 211 211 LYS B 234 234 GLU A Protein S 4 FT #SUB 212 212 MET B 161 161 GLN A Protein A 5 FT #SUB 212 212 MET B 236 236 TYR A Protein S 8 FT #SUB 212 212 MET B 271 271 ARG A Protein S 1 FT #SUB 212 212 MET B 273 273 ASP A Protein S 3 FT #SUB 212 212 MET B 455 455 GLU A Protein S 6 FT #SUB 215 215 ARG B 273 273 ASP A Protein S 5 FT #SUB 215 215 ARG B 275 275 ARG A Protein S 16 FT #SUB 215 215 ARG B 455 455 GLU A Protein S 5 FT #SUB 216 216 HIS B 271 271 ARG A Protein S 1 FT #SUB 216 216 HIS B 455 455 GLU A Protein S 4 FT #SUB 231 231 PHE B 192 192 GLN A Protein S 12 FT #SUB 234 234 GLU B 200 200 VAL A Protein S 1 FT #SUB 234 234 GLU B 211 211 LYS A Protein S 4 FT #SUB 236 236 TYR B 212 212 MET A Protein S 8 FT #SUB 252 252 ALA B 412 412 ASN A Protein S 1 FT #SUB 253 253 TYR B 412 412 ASN A Protein B 2 FT #SUB 254 254 ARG B 380 380 LYS A Protein S 8 FT #SUB 254 254 ARG B 409 409 TYR A Protein S 12 FT #SUB 254 254 ARG B 410 410 VAL A Protein S 4 FT #SUB 254 254 ARG B 411 411 THR A Protein S 3 FT #SUB 254 254 ARG B 412 412 ASN A Protein S 4 FT #SUB 255 255 GLU B 380 380 LYS A Protein A 2 FT #SUB 256 256 ASN B 382 382 ARG A Protein S 6 FT #SUB 264 264 SER B 409 409 TYR A Protein A 6 FT #SUB 266 266 PHE B 407 407 GLN A Protein S 6 FT #SUB 266 266 PHE B 409 409 TYR A Protein S 18 FT #SUB 266 266 PHE B 417 417 SER A Protein S 1 FT #SUB 266 266 PHE B 418 418 CYS A Protein S 1 FT #SUB 266 266 PHE B 419 419 ASN A Protein S 11 FT #SUB 267 267 GLY B 271 271 ARG A Protein B 3 FT #SUB 267 267 GLY B 419 419 ASN A Protein B 4 FT #SUB 268 268 GLN B 271 271 ARG A Protein S 2 FT #SUB 269 269 MET B 269 269 MET A Protein S 5 FT #SUB 271 271 ARG B 212 212 MET A Protein S 1 FT #SUB 271 271 ARG B 216 216 HIS A Protein S 1 FT #SUB 271 271 ARG B 267 267 GLY A Protein S 3 FT #SUB 271 271 ARG B 268 268 GLN A Protein S 2 FT #SUB 273 273 ASP B 212 212 MET A Protein A 3 FT #SUB 273 273 ASP B 215 215 ARG A Protein S 5 FT #SUB 275 275 ARG B 209 209 ILE A Protein S 2 FT #SUB 275 275 ARG B 215 215 ARG A Protein S 19 FT #SUB 276 276 GLU B 210 210 ARG A Protein S 12 FT #SUB 349 349 TYR B 349 349 TYR A Protein S 5 FT #SUB 349 349 TYR B 391 391 PRO A Protein S 7 FT #SUB 350 350 ASN B 350 350 ASN A Protein S 8 FT #SUB 350 350 ASN B 390 390 ASN A Protein S 1 FT #SUB 350 350 ASN B 392 392 SER A Protein S 4 FT #SUB 365 365 VAL B 392 392 SER A Protein S 1 FT #SUB 367 367 GLN B 391 391 PRO A Protein S 2 FT #SUB 380 380 LYS B 254 254 ARG A Protein A 9 FT #SUB 380 380 LYS B 255 255 GLU A Protein S 2 FT #SUB 382 382 ARG B 256 256 ASN A Protein S 6 FT #SUB 382 382 ARG B 423 423 ARG A Protein A 6 FT #SUB 382 382 ARG B 424 424 SER A Protein S 3 FT #SUB 382 382 ARG B 462 462 ASP A Protein S 4 FT #SUB 382 382 ARG B 464 464 HIS A Protein S 8 FT #SUB 382 382 ARG B 466 466 TYR A Protein S 3 FT #SUB 383 383 ARG B 400 400 PRO A Protein S 7 FT #SUB 383 383 ARG B 423 423 ARG A Protein S 6 FT #SUB 385 385 ILE B 389 389 TRP A Protein S 6 FT #SUB 385 385 ILE B 423 423 ARG A Protein S 3 FT #SUB 387 387 THR B 389 389 TRP A Protein S 1 FT #SUB 387 387 THR B 391 391 PRO A Protein S 1 FT #SUB 389 389 TRP B 385 385 ILE A Protein S 6 FT #SUB 389 389 TRP B 387 387 THR A Protein S 1 FT #SUB 390 390 ASN B 350 350 ASN A Protein S 1 FT #SUB 391 391 PRO B 349 349 TYR A Protein S 7 FT #SUB 391 391 PRO B 367 367 GLN A Protein S 2 FT #SUB 391 391 PRO B 387 387 THR A Protein S 1 FT #SUB 392 392 SER B 350 350 ASN A Protein S 4 FT #SUB 392 392 SER B 365 365 VAL A Protein S 1 FT #SUB 400 400 PRO B 383 383 ARG A Protein S 8 FT #SUB 404 404 VAL B 405 405 LEU A Protein S 1 FT #SUB 405 405 LEU B 404 404 VAL A Protein S 1 FT #SUB 405 405 LEU B 421 421 TYR A Protein S 2 FT #SUB 407 407 GLN B 266 266 PHE A Protein A 7 FT #SUB 407 407 GLN B 421 421 TYR A Protein S 6 FT #SUB 407 407 GLN B 423 423 ARG A Protein S 11 FT #SUB 407 407 GLN B 461 461 GLY A Protein S 1 FT #SUB 409 409 TYR B 254 254 ARG A Protein S 12 FT #SUB 409 409 TYR B 264 264 SER A Protein S 6 FT #SUB 409 409 TYR B 266 266 PHE A Protein S 18 FT #SUB 409 409 TYR B 462 462 ASP A Protein S 2 FT #SUB 410 410 VAL B 254 254 ARG A Protein B 4 FT #SUB 411 411 THR B 254 254 ARG A Protein B 3 FT #SUB 412 412 ASN B 252 252 ALA A Protein S 1 FT #SUB 412 412 ASN B 253 253 TYR A Protein S 2 FT #SUB 412 412 ASN B 254 254 ARG A Protein A 4 FT #SUB 417 417 SER B 266 266 PHE A Protein S 1 FT #SUB 418 418 CYS B 266 266 PHE A Protein B 1 FT #SUB 419 419 ASN B 266 266 PHE A Protein A 11 FT #SUB 419 419 ASN B 267 267 GLY A Protein S 4 FT #SUB 419 419 ASN B 421 421 TYR A Protein S 3 FT #SUB 419 419 ASN B 460 460 ILE A Protein S 1 FT #SUB 419 419 ASN B 461 461 GLY A Protein S 1 FT #SUB 421 421 TYR B 405 405 LEU A Protein S 1 FT #SUB 421 421 TYR B 407 407 GLN A Protein S 5 FT #SUB 421 421 TYR B 419 419 ASN A Protein S 4 FT #SUB 421 421 TYR B 459 459 PHE A Protein S 2 FT #SUB 423 423 ARG B 382 382 ARG A Protein S 6 FT #SUB 423 423 ARG B 383 383 ARG A Protein S 6 FT #SUB 423 423 ARG B 385 385 ILE A Protein S 2 FT #SUB 423 423 ARG B 407 407 GLN A Protein A 11 FT #SUB 424 424 SER B 382 382 ARG A Protein S 3 FT #SUB 455 455 GLU B 212 212 MET A Protein S 6 FT #SUB 455 455 GLU B 215 215 ARG A Protein S 5 FT #SUB 455 455 GLU B 216 216 HIS A Protein S 4 FT #SUB 459 459 PHE B 421 421 TYR A Protein S 2 FT #SUB 459 459 PHE B 459 459 PHE A Protein S 12 FT #SUB 460 460 ILE B 419 419 ASN A Protein B 1 FT #SUB 461 461 GLY B 407 407 GLN A Protein B 1 FT #SUB 461 461 GLY B 419 419 ASN A Protein B 1 FT #SUB 462 462 ASP B 382 382 ARG A Protein S 3 FT #SUB 462 462 ASP B 409 409 TYR A Protein S 2 FT #SUB 464 464 HIS B 382 382 ARG A Protein S 8 FT #SUB 466 466 TYR B 382 382 ARG A Protein S 3 FT #HET 9 9 VAL B 7 609 F89 B A 8 FT #HET 10 10 VAL B 7 609 F89 B B 9 FT #HET 10 10 VAL B 8 610 NDP B A 5 FT #HET 11 11 ALA B 7 609 F89 B A 5 FT #HET 11 11 ALA B 8 610 NDP B A 9 FT #HET 19 19 ILE B 8 610 NDP B A 14 FT #HET 20 20 GLY B 8 610 NDP B B 2 FT #HET 21 21 ILE B 8 610 NDP B B 1 FT #HET 23 23 GLY B 8 610 NDP B B 6 FT #HET 24 24 GLN B 8 610 NDP B B 7 FT #HET 25 25 LEU B 7 609 F89 B S 5 FT #HET 25 25 LEU B 8 610 NDP B A 6 FT #HET 32 32 ASP B 7 609 F89 B S 8 FT #HET 33 33 LEU B 7 609 F89 B A 6 FT #HET 36 36 PHE B 7 609 F89 B S 10 FT #HET 37 37 SER B 7 609 F89 B S 7 FT #HET 55 55 GLY B 8 610 NDP B B 8 FT #HET 56 56 ARG B 8 610 NDP B A 14 FT #HET 57 57 LYS B 8 610 NDP B A 16 FT #HET 58 58 THR B 8 610 NDP B A 10 FT #HET 61 61 SER B 8 610 NDP B S 1 FT #HET 62 62 ILE B 7 609 F89 B A 6 FT #HET 67 67 LEU B 7 609 F89 B S 3 FT #HET 70 70 ARG B 7 609 F89 B S 8 FT #HET 75 75 ILE B 8 610 NDP B A 8 FT #HET 76 76 SER B 8 610 NDP B A 7 FT #HET 77 77 SER B 8 610 NDP B A 6 FT #HET 78 78 SER B 8 610 NDP B A 2 FT #HET 92 92 ARG B 8 610 NDP B B 2 FT #HET 113 113 CYS B 7 609 F89 B B 3 FT #HET 113 113 CYS B 8 610 NDP B B 2 FT #HET 114 114 GLY B 8 610 NDP B B 2 FT #HET 115 115 GLY B 8 610 NDP B B 12 FT #HET 116 116 GLU B 8 610 NDP B A 6 FT #HET 117 117 SER B 8 610 NDP B A 9 FT #HET 118 118 ILE B 8 610 NDP B A 4 FT #HET 119 119 TYR B 7 609 F89 B S 1 FT #HET 119 119 TYR B 8 610 NDP B S 2 FT #HET 121 121 ASP B 8 610 NDP B S 1 FT #HET 134 134 THR B 7 609 F89 B S 2 FT #HET 145 145 THR B 8 610 NDP B S 7 FT #HET 257 257 ARG B 5 607 UMP B S 9 FT #HET 290 290 SER B 6 608 F89 B S 2 FT #HET 294 294 GLU B 6 608 F89 B S 5 FT #HET 315 315 ILE B 6 608 F89 B S 15 FT #HET 316 316 TRP B 6 608 F89 B S 3 FT #HET 319 319 ASN B 6 608 F89 B S 1 FT #HET 382 382 ARG B 1 603 UMP A S 14 FT #HET 383 383 ARG B 1 603 UMP A S 6 FT #HET 399 399 LEU B 5 607 UMP B S 1 FT #HET 399 399 LEU B 6 608 F89 B S 1 FT #HET 402 402 CYS B 5 607 UMP B S 7 FT #HET 403 403 HIS B 5 607 UMP B S 2 FT #HET 422 422 GLN B 5 607 UMP B S 3 FT #HET 423 423 ARG B 5 607 UMP B S 6 FT #HET 424 424 SER B 5 607 UMP B A 6 FT #HET 425 425 CYS B 5 607 UMP B B 2 FT #HET 426 426 ASP B 5 607 UMP B A 4 FT #HET 426 426 ASP B 6 608 F89 B S 5 FT #HET 429 429 LEU B 6 608 F89 B S 1 FT #HET 430 430 GLY B 6 608 F89 B B 2 FT #HET 433 433 PHE B 6 608 F89 B S 36 FT #HET 434 434 ASN B 5 607 UMP B S 10 FT #HET 464 464 HIS B 5 607 UMP B S 3 FT #HET 466 466 TYR B 5 607 UMP B S 4 FT #HET 466 466 TYR B 6 608 F89 B S 2 FT #HET 519 519 MET B 6 608 F89 B S 6 FT #HET 520 520 ALA B 6 608 F89 B B 2 FT DISORDER 1 2 CC SEQUENCE 519 AA (ATOM); CC EKNVSIVVAA SVLSSGIGIN GQLPWSISED LKFFSKITNN KCDSNKKNAL IMGRKTWDSI CC GRRPLKNRII VVISSSLPQD EADPNVVVFR NLEDSIENLM NDDSIENIFV CGGESIYRDA CC LKDNFVDRIY LTRVALEDIE FDTYFPEIPE TFLPVYMSQT FCTKNISYDF MIFEKQEKKT CC LQNCDPARGQ LKSIDDTVDL LGEIFGIRKM GNRHKFPKEE IYNTPSIRFG REHYEFQYLD CC LLSRVLENGA YRENRTGIST YSIFGQMMRF DMRESFPLLT TKKVAIRSIF EELIWFIKGD CC TNGNHLIEKK VYIWSGNGSK EYLERIGLGH REENDLGPIY GFQWRHYNGE YKTMHDDYTG CC VGVDQLAKLI ETLKNNPKDR RHILTAWNPS ALSQMALPPC HVLSQYYVTN DNCLSCNLYQ CC RSCDLGLGSP FNIASYAILT MMLAQVCGYE PGELAIFIGD AHIYENHLTQ LKEQLSRTPR CC PFPQLKFKRK VENIEDFKWE DIELIGYYPY PTIKMDMAV CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSEKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKN CC ATOM --EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKN CC ************************************************ CC SEQRES ALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIEN CC ATOM ALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIEN CC ************************************************** CC SEQRES LMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEI CC ATOM LMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEI CC ************************************************** CC SEQRES PETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTV CC ATOM PETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTV CC ************************************************** CC SEQRES DLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLEN CC ATOM DLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLEN CC ************************************************** CC SEQRES GAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK CC ATOM GAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK CC ************************************************** CC SEQRES GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYN CC ATOM GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYN CC ************************************************** CC SEQRES GEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALP CC ATOM GEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALP CC ************************************************** CC SEQRES PCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCG CC ATOM PCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCG CC ************************************************** CC SEQRES YEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFK CC ATOM YEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFK CC ************************************************** CC SEQRES WEDIELIGYYPYPTIKMDMAV CC ATOM WEDIELIGYYPYPTIKMDMAV CC ********************* SQ SEQUENCE 521 AA; MW; CN; MSEKNVSIVV AASVLSSGIG INGQLPWSIS EDLKFFSKIT NNKCDSNKKN ALIMGRKTWD SIGRRPLKNR IIVVISSSLP QDEADPNVVV FRNLEDSIEN LMNDDSIENI FVCGGESIYR DALKDNFVDR IYLTRVALED IEFDTYFPEI PETFLPVYMS QTFCTKNISY DFMIFEKQEK KTLQNCDPAR GQLKSIDDTV DLLGEIFGIR KMGNRHKFPK EEIYNTPSIR FGREHYEFQY LDLLSRVLEN GAYRENRTGI STYSIFGQMM RFDMRESFPL LTTKKVAIRS IFEELIWFIK GDTNGNHLIE KKVYIWSGNG SKEYLERIGL GHREENDLGP IYGFQWRHYN GEYKTMHDDY TGVGVDQLAK LIETLKNNPK DRRHILTAWN PSALSQMALP PCHVLSQYYV TNDNCLSCNL YQRSCDLGLG SPFNIASYAI LTMMLAQVCG YEPGELAIFI GDAHIYENHL TQLKEQLSRT PRPFPQLKFK RKVENIEDFK WEDIELIGYY PYPTIKMDMA V // ID 1SEJC STANDARD; PRT; 521 AA. DT CONVERTED FROM PDB (SEQRES) 1SEJ DE bifunctional dihydrofolate reductase-thymidylate synthase OS Cryptosporidium hominis CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.870 CC R-Factor 0.220 FT #SUB 31 31 GLU C 206 206 ILE D Protein A 3 FT #SUB 31 31 GLU C 207 207 PHE D Protein S 4 FT #SUB 31 31 GLU C 210 210 ARG D Protein S 4 FT #SUB 34 34 LYS C 206 206 ILE D Protein A 2 FT #SUB 35 35 PHE C 203 203 LEU D Protein S 2 FT #SUB 35 35 PHE C 206 206 ILE D Protein A 4 FT #SUB 38 38 LYS C 202 202 LEU D Protein A 3 FT #SUB 38 38 LYS C 205 205 GLU D Protein S 4 FT #SUB 38 38 LYS C 206 206 ILE D Protein S 1 FT #SUB 39 39 ILE C 202 202 LEU D Protein A 2 FT #SUB 42 42 ASN C 198 198 ASP D Protein S 1 FT #SUB 44 44 CYS C 194 194 LYS D Protein S 1 FT #SUB 130 130 ARG C 195 195 SER D Protein S 2 FT #SUB 132 132 TYR C 199 199 THR D Protein S 1 FT #SUB 157 157 VAL C 196 196 ILE D Protein B 2 FT #SUB 158 158 TYR C 196 196 ILE D Protein S 1 FT #SUB 158 158 TYR C 200 200 VAL D Protein S 3 FT #SUB 158 158 TYR C 203 203 LEU D Protein S 1 FT #SUB 160 160 SER C 203 203 LEU D Protein S 1 FT #SUB 161 161 GLN C 210 210 ARG D Protein S 1 FT #SUB 161 161 GLN C 211 211 LYS D Protein S 3 FT #SUB 161 161 GLN C 212 212 MET D Protein S 5 FT #SUB 163 163 PHE C 207 207 PHE D Protein S 21 FT #SUB 163 163 PHE C 211 211 LYS D Protein S 2 FT #SUB 164 164 CYS C 210 210 ARG D Protein B 1 FT #SUB 170 170 TYR C 207 207 PHE D Protein S 3 FT #SUB 172 172 PHE C 203 203 LEU D Protein S 8 FT #SUB 172 172 PHE C 207 207 PHE D Protein S 2 FT #SUB 174 174 ILE C 195 195 SER D Protein S 2 FT #SUB 174 174 ILE C 199 199 THR D Protein S 2 FT #SUB 176 176 GLU C 193 193 LEU D Protein S 1 FT #SUB 176 176 GLU C 195 195 SER D Protein S 4 FT #SUB 192 192 GLN C 192 192 GLN D Protein S 8 FT #SUB 192 192 GLN C 231 231 PHE D Protein S 12 FT #SUB 193 193 LEU C 176 176 GLU D Protein S 1 FT #SUB 194 194 LYS C 44 44 CYS D Protein S 1 FT #SUB 195 195 SER C 130 130 ARG D Protein S 3 FT #SUB 195 195 SER C 174 174 ILE D Protein B 2 FT #SUB 195 195 SER C 176 176 GLU D Protein S 4 FT #SUB 196 196 ILE C 157 157 VAL D Protein S 1 FT #SUB 196 196 ILE C 231 231 PHE D Protein S 1 FT #SUB 198 198 ASP C 42 42 ASN D Protein S 1 FT #SUB 199 199 THR C 132 132 TYR D Protein S 1 FT #SUB 199 199 THR C 174 174 ILE D Protein S 4 FT #SUB 200 200 VAL C 158 158 TYR D Protein S 3 FT #SUB 200 200 VAL C 234 234 GLU D Protein S 1 FT #SUB 202 202 LEU C 38 38 LYS D Protein S 3 FT #SUB 202 202 LEU C 39 39 ILE D Protein S 3 FT #SUB 203 203 LEU C 35 35 PHE D Protein S 2 FT #SUB 203 203 LEU C 158 158 TYR D Protein S 1 FT #SUB 203 203 LEU C 160 160 SER D Protein S 1 FT #SUB 203 203 LEU C 172 172 PHE D Protein S 8 FT #SUB 205 205 GLU C 38 38 LYS D Protein S 4 FT #SUB 206 206 ILE C 31 31 GLU D Protein S 3 FT #SUB 206 206 ILE C 34 34 LYS D Protein S 3 FT #SUB 206 206 ILE C 35 35 PHE D Protein S 4 FT #SUB 206 206 ILE C 38 38 LYS D Protein A 2 FT #SUB 207 207 PHE C 31 31 GLU D Protein S 4 FT #SUB 207 207 PHE C 163 163 PHE D Protein S 21 FT #SUB 207 207 PHE C 170 170 TYR D Protein S 3 FT #SUB 207 207 PHE C 172 172 PHE D Protein S 2 FT #SUB 209 209 ILE C 275 275 ARG D Protein S 1 FT #SUB 210 210 ARG C 31 31 GLU D Protein S 5 FT #SUB 210 210 ARG C 161 161 GLN D Protein B 1 FT #SUB 210 210 ARG C 164 164 CYS D Protein S 1 FT #SUB 210 210 ARG C 276 276 GLU D Protein A 12 FT #SUB 211 211 LYS C 161 161 GLN D Protein A 3 FT #SUB 211 211 LYS C 163 163 PHE D Protein A 2 FT #SUB 211 211 LYS C 234 234 GLU D Protein S 6 FT #SUB 212 212 MET C 161 161 GLN D Protein A 5 FT #SUB 212 212 MET C 236 236 TYR D Protein S 9 FT #SUB 212 212 MET C 271 271 ARG D Protein S 1 FT #SUB 212 212 MET C 273 273 ASP D Protein S 3 FT #SUB 212 212 MET C 455 455 GLU D Protein S 5 FT #SUB 215 215 ARG C 273 273 ASP D Protein S 5 FT #SUB 215 215 ARG C 275 275 ARG D Protein S 9 FT #SUB 215 215 ARG C 455 455 GLU D Protein S 5 FT #SUB 216 216 HIS C 271 271 ARG D Protein S 1 FT #SUB 216 216 HIS C 455 455 GLU D Protein S 4 FT #SUB 231 231 PHE C 192 192 GLN D Protein S 12 FT #SUB 231 231 PHE C 193 193 LEU D Protein S 1 FT #SUB 231 231 PHE C 196 196 ILE D Protein B 3 FT #SUB 234 234 GLU C 200 200 VAL D Protein S 1 FT #SUB 234 234 GLU C 211 211 LYS D Protein S 6 FT #SUB 236 236 TYR C 212 212 MET D Protein S 9 FT #SUB 252 252 ALA C 412 412 ASN D Protein S 1 FT #SUB 253 253 TYR C 412 412 ASN D Protein B 1 FT #SUB 254 254 ARG C 380 380 LYS D Protein S 7 FT #SUB 254 254 ARG C 409 409 TYR D Protein S 13 FT #SUB 254 254 ARG C 410 410 VAL D Protein S 4 FT #SUB 254 254 ARG C 411 411 THR D Protein S 3 FT #SUB 254 254 ARG C 412 412 ASN D Protein S 4 FT #SUB 255 255 GLU C 380 380 LYS D Protein A 2 FT #SUB 256 256 ASN C 382 382 ARG D Protein S 6 FT #SUB 264 264 SER C 409 409 TYR D Protein A 5 FT #SUB 266 266 PHE C 407 407 GLN D Protein S 5 FT #SUB 266 266 PHE C 409 409 TYR D Protein S 13 FT #SUB 266 266 PHE C 417 417 SER D Protein S 1 FT #SUB 266 266 PHE C 418 418 CYS D Protein S 1 FT #SUB 266 266 PHE C 419 419 ASN D Protein S 13 FT #SUB 267 267 GLY C 271 271 ARG D Protein B 3 FT #SUB 267 267 GLY C 419 419 ASN D Protein B 4 FT #SUB 267 267 GLY C 459 459 PHE D Protein B 1 FT #SUB 268 268 GLN C 271 271 ARG D Protein S 2 FT #SUB 269 269 MET C 269 269 MET D Protein S 1 FT #SUB 271 271 ARG C 212 212 MET D Protein S 1 FT #SUB 271 271 ARG C 216 216 HIS D Protein S 1 FT #SUB 271 271 ARG C 267 267 GLY D Protein S 3 FT #SUB 271 271 ARG C 268 268 GLN D Protein S 2 FT #SUB 273 273 ASP C 212 212 MET D Protein A 3 FT #SUB 273 273 ASP C 215 215 ARG D Protein S 5 FT #SUB 275 275 ARG C 209 209 ILE D Protein S 2 FT #SUB 275 275 ARG C 215 215 ARG D Protein S 12 FT #SUB 276 276 GLU C 210 210 ARG D Protein S 12 FT #SUB 349 349 TYR C 349 349 TYR D Protein S 5 FT #SUB 349 349 TYR C 391 391 PRO D Protein S 7 FT #SUB 350 350 ASN C 350 350 ASN D Protein S 6 FT #SUB 350 350 ASN C 390 390 ASN D Protein S 1 FT #SUB 350 350 ASN C 392 392 SER D Protein S 4 FT #SUB 365 365 VAL C 392 392 SER D Protein S 1 FT #SUB 367 367 GLN C 391 391 PRO D Protein S 2 FT #SUB 380 380 LYS C 254 254 ARG D Protein A 8 FT #SUB 380 380 LYS C 255 255 GLU D Protein S 2 FT #SUB 382 382 ARG C 256 256 ASN D Protein S 7 FT #SUB 382 382 ARG C 423 423 ARG D Protein A 5 FT #SUB 382 382 ARG C 424 424 SER D Protein S 2 FT #SUB 382 382 ARG C 462 462 ASP D Protein S 4 FT #SUB 382 382 ARG C 464 464 HIS D Protein S 7 FT #SUB 382 382 ARG C 466 466 TYR D Protein S 3 FT #SUB 383 383 ARG C 400 400 PRO D Protein S 6 FT #SUB 383 383 ARG C 423 423 ARG D Protein S 6 FT #SUB 385 385 ILE C 389 389 TRP D Protein S 5 FT #SUB 385 385 ILE C 423 423 ARG D Protein S 2 FT #SUB 387 387 THR C 389 389 TRP D Protein S 1 FT #SUB 387 387 THR C 391 391 PRO D Protein S 1 FT #SUB 389 389 TRP C 385 385 ILE D Protein S 7 FT #SUB 389 389 TRP C 387 387 THR D Protein S 1 FT #SUB 390 390 ASN C 350 350 ASN D Protein S 1 FT #SUB 391 391 PRO C 349 349 TYR D Protein S 7 FT #SUB 391 391 PRO C 367 367 GLN D Protein S 2 FT #SUB 391 391 PRO C 387 387 THR D Protein S 1 FT #SUB 392 392 SER C 350 350 ASN D Protein S 4 FT #SUB 392 392 SER C 365 365 VAL D Protein S 1 FT #SUB 400 400 PRO C 383 383 ARG D Protein S 7 FT #SUB 404 404 VAL C 405 405 LEU D Protein S 1 FT #SUB 405 405 LEU C 404 404 VAL D Protein S 1 FT #SUB 405 405 LEU C 421 421 TYR D Protein S 1 FT #SUB 407 407 GLN C 266 266 PHE D Protein A 7 FT #SUB 407 407 GLN C 421 421 TYR D Protein S 5 FT #SUB 407 407 GLN C 423 423 ARG D Protein S 11 FT #SUB 407 407 GLN C 461 461 GLY D Protein S 1 FT #SUB 409 409 TYR C 254 254 ARG D Protein S 13 FT #SUB 409 409 TYR C 264 264 SER D Protein S 5 FT #SUB 409 409 TYR C 266 266 PHE D Protein S 14 FT #SUB 409 409 TYR C 462 462 ASP D Protein S 2 FT #SUB 410 410 VAL C 254 254 ARG D Protein B 4 FT #SUB 411 411 THR C 254 254 ARG D Protein B 2 FT #SUB 412 412 ASN C 252 252 ALA D Protein S 1 FT #SUB 412 412 ASN C 253 253 TYR D Protein S 1 FT #SUB 412 412 ASN C 254 254 ARG D Protein A 4 FT #SUB 417 417 SER C 266 266 PHE D Protein S 1 FT #SUB 418 418 CYS C 266 266 PHE D Protein B 1 FT #SUB 419 419 ASN C 266 266 PHE D Protein A 12 FT #SUB 419 419 ASN C 267 267 GLY D Protein S 4 FT #SUB 419 419 ASN C 421 421 TYR D Protein S 3 FT #SUB 419 419 ASN C 460 460 ILE D Protein S 1 FT #SUB 419 419 ASN C 461 461 GLY D Protein S 1 FT #SUB 421 421 TYR C 405 405 LEU D Protein S 1 FT #SUB 421 421 TYR C 407 407 GLN D Protein S 5 FT #SUB 421 421 TYR C 419 419 ASN D Protein S 3 FT #SUB 421 421 TYR C 459 459 PHE D Protein S 2 FT #SUB 423 423 ARG C 382 382 ARG D Protein S 5 FT #SUB 423 423 ARG C 383 383 ARG D Protein S 5 FT #SUB 423 423 ARG C 385 385 ILE D Protein S 2 FT #SUB 423 423 ARG C 407 407 GLN D Protein A 11 FT #SUB 424 424 SER C 382 382 ARG D Protein S 2 FT #SUB 455 455 GLU C 212 212 MET D Protein S 7 FT #SUB 455 455 GLU C 215 215 ARG D Protein S 5 FT #SUB 455 455 GLU C 216 216 HIS D Protein S 4 FT #SUB 459 459 PHE C 267 267 GLY D Protein S 1 FT #SUB 459 459 PHE C 421 421 TYR D Protein S 2 FT #SUB 459 459 PHE C 459 459 PHE D Protein S 10 FT #SUB 460 460 ILE C 419 419 ASN D Protein B 1 FT #SUB 461 461 GLY C 407 407 GLN D Protein B 1 FT #SUB 461 461 GLY C 419 419 ASN D Protein B 1 FT #SUB 462 462 ASP C 382 382 ARG D Protein S 3 FT #SUB 462 462 ASP C 409 409 TYR D Protein S 2 FT #SUB 464 464 HIS C 382 382 ARG D Protein S 5 FT #SUB 466 466 TYR C 382 382 ARG D Protein S 3 FT #HET 9 9 VAL C 11 613 F89 C A 6 FT #HET 10 10 VAL C 11 613 F89 C B 9 FT #HET 10 10 VAL C 12 614 NDP C A 5 FT #HET 11 11 ALA C 11 613 F89 C A 6 FT #HET 11 11 ALA C 12 614 NDP C B 8 FT #HET 19 19 ILE C 12 614 NDP C A 10 FT #HET 20 20 GLY C 12 614 NDP C B 1 FT #HET 21 21 ILE C 12 614 NDP C B 1 FT #HET 23 23 GLY C 12 614 NDP C B 7 FT #HET 24 24 GLN C 12 614 NDP C B 7 FT #HET 25 25 LEU C 11 613 F89 C S 6 FT #HET 25 25 LEU C 12 614 NDP C A 5 FT #HET 32 32 ASP C 11 613 F89 C S 8 FT #HET 33 33 LEU C 11 613 F89 C A 7 FT #HET 36 36 PHE C 11 613 F89 C S 9 FT #HET 37 37 SER C 11 613 F89 C S 5 FT #HET 55 55 GLY C 12 614 NDP C B 10 FT #HET 56 56 ARG C 12 614 NDP C A 18 FT #HET 57 57 LYS C 12 614 NDP C A 17 FT #HET 58 58 THR C 12 614 NDP C A 11 FT #HET 61 61 SER C 12 614 NDP C S 2 FT #HET 62 62 ILE C 11 613 F89 C A 6 FT #HET 67 67 LEU C 11 613 F89 C S 4 FT #HET 70 70 ARG C 11 613 F89 C S 8 FT #HET 75 75 ILE C 12 614 NDP C A 10 FT #HET 76 76 SER C 12 614 NDP C A 10 FT #HET 77 77 SER C 12 614 NDP C A 7 FT #HET 78 78 SER C 12 614 NDP C A 2 FT #HET 92 92 ARG C 12 614 NDP C B 3 FT #HET 113 113 CYS C 11 613 F89 C B 3 FT #HET 113 113 CYS C 12 614 NDP C B 2 FT #HET 114 114 GLY C 12 614 NDP C B 2 FT #HET 115 115 GLY C 12 614 NDP C B 9 FT #HET 116 116 GLU C 12 614 NDP C A 5 FT #HET 117 117 SER C 12 614 NDP C A 7 FT #HET 118 118 ILE C 12 614 NDP C S 3 FT #HET 119 119 TYR C 11 613 F89 C S 1 FT #HET 119 119 TYR C 12 614 NDP C S 2 FT #HET 121 121 ASP C 12 614 NDP C S 1 FT #HET 134 134 THR C 11 613 F89 C S 2 FT #HET 145 145 THR C 12 614 NDP C S 4 FT #HET 257 257 ARG C 9 611 UMP C S 11 FT #HET 290 290 SER C 10 612 F89 C S 2 FT #HET 294 294 GLU C 10 612 F89 C S 5 FT #HET 315 315 ILE C 10 612 F89 C S 16 FT #HET 316 316 TRP C 10 612 F89 C S 3 FT #HET 319 319 ASN C 10 612 F89 C S 1 FT #HET 382 382 ARG C 13 615 UMP D S 12 FT #HET 383 383 ARG C 13 615 UMP D S 5 FT #HET 399 399 LEU C 9 611 UMP C S 1 FT #HET 399 399 LEU C 10 612 F89 C S 1 FT #HET 402 402 CYS C 9 611 UMP C S 7 FT #HET 403 403 HIS C 9 611 UMP C S 2 FT #HET 422 422 GLN C 9 611 UMP C S 3 FT #HET 423 423 ARG C 9 611 UMP C S 6 FT #HET 424 424 SER C 9 611 UMP C A 7 FT #HET 425 425 CYS C 9 611 UMP C B 2 FT #HET 426 426 ASP C 9 611 UMP C A 5 FT #HET 426 426 ASP C 10 612 F89 C S 8 FT #HET 429 429 LEU C 10 612 F89 C S 1 FT #HET 430 430 GLY C 10 612 F89 C B 2 FT #HET 433 433 PHE C 10 612 F89 C S 38 FT #HET 434 434 ASN C 9 611 UMP C S 8 FT #HET 464 464 HIS C 9 611 UMP C S 3 FT #HET 466 466 TYR C 9 611 UMP C S 4 FT #HET 466 466 TYR C 10 612 F89 C S 3 FT #HET 519 519 MET C 10 612 F89 C S 6 FT #HET 520 520 ALA C 10 612 F89 C B 2 FT DISORDER 1 2 CC SEQUENCE 519 AA (ATOM); CC EKNVSIVVAA SVLSSGIGIN GQLPWSISED LKFFSKITNN KCDSNKKNAL IMGRKTWDSI CC GRRPLKNRII VVISSSLPQD EADPNVVVFR NLEDSIENLM NDDSIENIFV CGGESIYRDA CC LKDNFVDRIY LTRVALEDIE FDTYFPEIPE TFLPVYMSQT FCTKNISYDF MIFEKQEKKT CC LQNCDPARGQ LKSIDDTVDL LGEIFGIRKM GNRHKFPKEE IYNTPSIRFG REHYEFQYLD CC LLSRVLENGA YRENRTGIST YSIFGQMMRF DMRESFPLLT TKKVAIRSIF EELIWFIKGD CC TNGNHLIEKK VYIWSGNGSK EYLERIGLGH REENDLGPIY GFQWRHYNGE YKTMHDDYTG CC VGVDQLAKLI ETLKNNPKDR RHILTAWNPS ALSQMALPPC HVLSQYYVTN DNCLSCNLYQ CC RSCDLGLGSP FNIASYAILT MMLAQVCGYE PGELAIFIGD AHIYENHLTQ LKEQLSRTPR CC PFPQLKFKRK VENIEDFKWE DIELIGYYPY PTIKMDMAV CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSEKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKN CC ATOM --EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKN CC ************************************************ CC SEQRES ALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIEN CC ATOM ALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIEN CC ************************************************** CC SEQRES LMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEI CC ATOM LMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEI CC ************************************************** CC SEQRES PETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTV CC ATOM PETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTV CC ************************************************** CC SEQRES DLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLEN CC ATOM DLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLEN CC ************************************************** CC SEQRES GAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK CC ATOM GAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK CC ************************************************** CC SEQRES GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYN CC ATOM GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYN CC ************************************************** CC SEQRES GEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALP CC ATOM GEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALP CC ************************************************** CC SEQRES PCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCG CC ATOM PCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCG CC ************************************************** CC SEQRES YEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFK CC ATOM YEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFK CC ************************************************** CC SEQRES WEDIELIGYYPYPTIKMDMAV CC ATOM WEDIELIGYYPYPTIKMDMAV CC ********************* SQ SEQUENCE 521 AA; MW; CN; MSEKNVSIVV AASVLSSGIG INGQLPWSIS EDLKFFSKIT NNKCDSNKKN ALIMGRKTWD SIGRRPLKNR IIVVISSSLP QDEADPNVVV FRNLEDSIEN LMNDDSIENI FVCGGESIYR DALKDNFVDR IYLTRVALED IEFDTYFPEI PETFLPVYMS QTFCTKNISY DFMIFEKQEK KTLQNCDPAR GQLKSIDDTV DLLGEIFGIR KMGNRHKFPK EEIYNTPSIR FGREHYEFQY LDLLSRVLEN GAYRENRTGI STYSIFGQMM RFDMRESFPL LTTKKVAIRS IFEELIWFIK GDTNGNHLIE KKVYIWSGNG SKEYLERIGL GHREENDLGP IYGFQWRHYN GEYKTMHDDY TGVGVDQLAK LIETLKNNPK DRRHILTAWN PSALSQMALP PCHVLSQYYV TNDNCLSCNL YQRSCDLGLG SPFNIASYAI LTMMLAQVCG YEPGELAIFI GDAHIYENHL TQLKEQLSRT PRPFPQLKFK RKVENIEDFK WEDIELIGYY PYPTIKMDMA V // ID 1SEJD STANDARD; PRT; 521 AA. DT CONVERTED FROM PDB (SEQRES) 1SEJ DE bifunctional dihydrofolate reductase-thymidylate synthase OS Cryptosporidium hominis CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.870 CC R-Factor 0.220 FT #SUB 31 31 GLU D 206 206 ILE C Protein A 3 FT #SUB 31 31 GLU D 207 207 PHE C Protein S 4 FT #SUB 31 31 GLU D 210 210 ARG C Protein S 5 FT #SUB 34 34 LYS D 206 206 ILE C Protein A 3 FT #SUB 35 35 PHE D 203 203 LEU C Protein S 2 FT #SUB 35 35 PHE D 206 206 ILE C Protein A 4 FT #SUB 38 38 LYS D 202 202 LEU C Protein A 3 FT #SUB 38 38 LYS D 205 205 GLU C Protein S 4 FT #SUB 38 38 LYS D 206 206 ILE C Protein S 2 FT #SUB 39 39 ILE D 202 202 LEU C Protein A 3 FT #SUB 42 42 ASN D 198 198 ASP C Protein S 1 FT #SUB 44 44 CYS D 194 194 LYS C Protein S 1 FT #SUB 130 130 ARG D 195 195 SER C Protein S 3 FT #SUB 132 132 TYR D 199 199 THR C Protein S 1 FT #SUB 157 157 VAL D 196 196 ILE C Protein B 1 FT #SUB 158 158 TYR D 200 200 VAL C Protein S 3 FT #SUB 158 158 TYR D 203 203 LEU C Protein S 1 FT #SUB 160 160 SER D 203 203 LEU C Protein S 1 FT #SUB 161 161 GLN D 210 210 ARG C Protein S 1 FT #SUB 161 161 GLN D 211 211 LYS C Protein S 3 FT #SUB 161 161 GLN D 212 212 MET C Protein S 5 FT #SUB 163 163 PHE D 207 207 PHE C Protein S 21 FT #SUB 163 163 PHE D 211 211 LYS C Protein S 2 FT #SUB 164 164 CYS D 210 210 ARG C Protein B 1 FT #SUB 170 170 TYR D 207 207 PHE C Protein S 3 FT #SUB 172 172 PHE D 203 203 LEU C Protein S 8 FT #SUB 172 172 PHE D 207 207 PHE C Protein S 2 FT #SUB 174 174 ILE D 195 195 SER C Protein S 2 FT #SUB 174 174 ILE D 199 199 THR C Protein S 4 FT #SUB 176 176 GLU D 193 193 LEU C Protein S 1 FT #SUB 176 176 GLU D 195 195 SER C Protein S 4 FT #SUB 192 192 GLN D 192 192 GLN C Protein S 8 FT #SUB 192 192 GLN D 231 231 PHE C Protein S 12 FT #SUB 193 193 LEU D 176 176 GLU C Protein S 1 FT #SUB 193 193 LEU D 231 231 PHE C Protein S 1 FT #SUB 194 194 LYS D 44 44 CYS C Protein S 1 FT #SUB 195 195 SER D 130 130 ARG C Protein S 2 FT #SUB 195 195 SER D 174 174 ILE C Protein B 2 FT #SUB 195 195 SER D 176 176 GLU C Protein S 4 FT #SUB 196 196 ILE D 157 157 VAL C Protein S 2 FT #SUB 196 196 ILE D 158 158 TYR C Protein S 1 FT #SUB 196 196 ILE D 231 231 PHE C Protein S 3 FT #SUB 198 198 ASP D 42 42 ASN C Protein S 1 FT #SUB 199 199 THR D 132 132 TYR C Protein S 1 FT #SUB 199 199 THR D 174 174 ILE C Protein S 2 FT #SUB 200 200 VAL D 158 158 TYR C Protein S 3 FT #SUB 200 200 VAL D 234 234 GLU C Protein S 1 FT #SUB 202 202 LEU D 38 38 LYS C Protein S 3 FT #SUB 202 202 LEU D 39 39 ILE C Protein S 2 FT #SUB 203 203 LEU D 35 35 PHE C Protein S 2 FT #SUB 203 203 LEU D 158 158 TYR C Protein S 1 FT #SUB 203 203 LEU D 160 160 SER C Protein S 1 FT #SUB 203 203 LEU D 172 172 PHE C Protein S 8 FT #SUB 205 205 GLU D 38 38 LYS C Protein S 4 FT #SUB 206 206 ILE D 31 31 GLU C Protein S 3 FT #SUB 206 206 ILE D 34 34 LYS C Protein S 2 FT #SUB 206 206 ILE D 35 35 PHE C Protein S 4 FT #SUB 206 206 ILE D 38 38 LYS C Protein S 1 FT #SUB 207 207 PHE D 31 31 GLU C Protein S 4 FT #SUB 207 207 PHE D 163 163 PHE C Protein S 21 FT #SUB 207 207 PHE D 170 170 TYR C Protein S 3 FT #SUB 207 207 PHE D 172 172 PHE C Protein S 2 FT #SUB 209 209 ILE D 275 275 ARG C Protein A 2 FT #SUB 210 210 ARG D 31 31 GLU C Protein S 4 FT #SUB 210 210 ARG D 161 161 GLN C Protein B 1 FT #SUB 210 210 ARG D 164 164 CYS C Protein S 1 FT #SUB 210 210 ARG D 276 276 GLU C Protein A 12 FT #SUB 211 211 LYS D 161 161 GLN C Protein A 3 FT #SUB 211 211 LYS D 163 163 PHE C Protein A 2 FT #SUB 211 211 LYS D 234 234 GLU C Protein S 6 FT #SUB 212 212 MET D 161 161 GLN C Protein A 5 FT #SUB 212 212 MET D 236 236 TYR C Protein S 9 FT #SUB 212 212 MET D 271 271 ARG C Protein S 1 FT #SUB 212 212 MET D 273 273 ASP C Protein S 3 FT #SUB 212 212 MET D 455 455 GLU C Protein S 7 FT #SUB 215 215 ARG D 273 273 ASP C Protein S 5 FT #SUB 215 215 ARG D 275 275 ARG C Protein S 12 FT #SUB 215 215 ARG D 455 455 GLU C Protein S 5 FT #SUB 216 216 HIS D 271 271 ARG C Protein S 1 FT #SUB 216 216 HIS D 455 455 GLU C Protein S 4 FT #SUB 231 231 PHE D 192 192 GLN C Protein S 12 FT #SUB 231 231 PHE D 196 196 ILE C Protein B 1 FT #SUB 234 234 GLU D 200 200 VAL C Protein S 1 FT #SUB 234 234 GLU D 211 211 LYS C Protein S 6 FT #SUB 236 236 TYR D 212 212 MET C Protein S 9 FT #SUB 252 252 ALA D 412 412 ASN C Protein S 1 FT #SUB 253 253 TYR D 412 412 ASN C Protein B 1 FT #SUB 254 254 ARG D 380 380 LYS C Protein S 8 FT #SUB 254 254 ARG D 409 409 TYR C Protein S 13 FT #SUB 254 254 ARG D 410 410 VAL C Protein S 4 FT #SUB 254 254 ARG D 411 411 THR C Protein S 2 FT #SUB 254 254 ARG D 412 412 ASN C Protein S 4 FT #SUB 255 255 GLU D 380 380 LYS C Protein A 2 FT #SUB 256 256 ASN D 382 382 ARG C Protein S 7 FT #SUB 264 264 SER D 409 409 TYR C Protein A 5 FT #SUB 266 266 PHE D 407 407 GLN C Protein S 7 FT #SUB 266 266 PHE D 409 409 TYR C Protein S 14 FT #SUB 266 266 PHE D 417 417 SER C Protein S 1 FT #SUB 266 266 PHE D 418 418 CYS C Protein S 1 FT #SUB 266 266 PHE D 419 419 ASN C Protein S 12 FT #SUB 267 267 GLY D 271 271 ARG C Protein B 3 FT #SUB 267 267 GLY D 419 419 ASN C Protein B 4 FT #SUB 267 267 GLY D 459 459 PHE C Protein B 1 FT #SUB 268 268 GLN D 271 271 ARG C Protein S 2 FT #SUB 269 269 MET D 269 269 MET C Protein S 1 FT #SUB 271 271 ARG D 212 212 MET C Protein S 1 FT #SUB 271 271 ARG D 216 216 HIS C Protein S 1 FT #SUB 271 271 ARG D 267 267 GLY C Protein S 3 FT #SUB 271 271 ARG D 268 268 GLN C Protein S 2 FT #SUB 273 273 ASP D 212 212 MET C Protein A 3 FT #SUB 273 273 ASP D 215 215 ARG C Protein S 5 FT #SUB 275 275 ARG D 209 209 ILE C Protein S 1 FT #SUB 275 275 ARG D 215 215 ARG C Protein S 9 FT #SUB 276 276 GLU D 210 210 ARG C Protein S 12 FT #SUB 349 349 TYR D 349 349 TYR C Protein S 5 FT #SUB 349 349 TYR D 391 391 PRO C Protein S 7 FT #SUB 350 350 ASN D 350 350 ASN C Protein S 6 FT #SUB 350 350 ASN D 390 390 ASN C Protein S 1 FT #SUB 350 350 ASN D 392 392 SER C Protein S 4 FT #SUB 365 365 VAL D 392 392 SER C Protein S 1 FT #SUB 367 367 GLN D 391 391 PRO C Protein S 2 FT #SUB 380 380 LYS D 254 254 ARG C Protein A 7 FT #SUB 380 380 LYS D 255 255 GLU C Protein S 2 FT #SUB 382 382 ARG D 256 256 ASN C Protein S 6 FT #SUB 382 382 ARG D 423 423 ARG C Protein A 5 FT #SUB 382 382 ARG D 424 424 SER C Protein S 2 FT #SUB 382 382 ARG D 462 462 ASP C Protein S 3 FT #SUB 382 382 ARG D 464 464 HIS C Protein S 5 FT #SUB 382 382 ARG D 466 466 TYR C Protein S 3 FT #SUB 383 383 ARG D 400 400 PRO C Protein S 7 FT #SUB 383 383 ARG D 423 423 ARG C Protein S 5 FT #SUB 385 385 ILE D 389 389 TRP C Protein S 7 FT #SUB 385 385 ILE D 423 423 ARG C Protein S 2 FT #SUB 387 387 THR D 389 389 TRP C Protein S 1 FT #SUB 387 387 THR D 391 391 PRO C Protein S 1 FT #SUB 389 389 TRP D 385 385 ILE C Protein S 5 FT #SUB 389 389 TRP D 387 387 THR C Protein S 1 FT #SUB 390 390 ASN D 350 350 ASN C Protein S 1 FT #SUB 391 391 PRO D 349 349 TYR C Protein S 7 FT #SUB 391 391 PRO D 367 367 GLN C Protein S 2 FT #SUB 391 391 PRO D 387 387 THR C Protein S 1 FT #SUB 392 392 SER D 350 350 ASN C Protein S 4 FT #SUB 392 392 SER D 365 365 VAL C Protein S 1 FT #SUB 400 400 PRO D 383 383 ARG C Protein S 6 FT #SUB 404 404 VAL D 405 405 LEU C Protein S 1 FT #SUB 405 405 LEU D 404 404 VAL C Protein S 1 FT #SUB 405 405 LEU D 421 421 TYR C Protein S 1 FT #SUB 407 407 GLN D 266 266 PHE C Protein A 5 FT #SUB 407 407 GLN D 421 421 TYR C Protein S 5 FT #SUB 407 407 GLN D 423 423 ARG C Protein S 11 FT #SUB 407 407 GLN D 461 461 GLY C Protein S 1 FT #SUB 409 409 TYR D 254 254 ARG C Protein S 13 FT #SUB 409 409 TYR D 264 264 SER C Protein S 5 FT #SUB 409 409 TYR D 266 266 PHE C Protein S 13 FT #SUB 409 409 TYR D 462 462 ASP C Protein S 2 FT #SUB 410 410 VAL D 254 254 ARG C Protein B 4 FT #SUB 411 411 THR D 254 254 ARG C Protein B 3 FT #SUB 412 412 ASN D 252 252 ALA C Protein S 1 FT #SUB 412 412 ASN D 253 253 TYR C Protein S 1 FT #SUB 412 412 ASN D 254 254 ARG C Protein A 4 FT #SUB 417 417 SER D 266 266 PHE C Protein S 1 FT #SUB 418 418 CYS D 266 266 PHE C Protein B 1 FT #SUB 419 419 ASN D 266 266 PHE C Protein A 13 FT #SUB 419 419 ASN D 267 267 GLY C Protein S 4 FT #SUB 419 419 ASN D 421 421 TYR C Protein S 3 FT #SUB 419 419 ASN D 460 460 ILE C Protein S 1 FT #SUB 419 419 ASN D 461 461 GLY C Protein S 1 FT #SUB 421 421 TYR D 405 405 LEU C Protein S 1 FT #SUB 421 421 TYR D 407 407 GLN C Protein S 5 FT #SUB 421 421 TYR D 419 419 ASN C Protein S 3 FT #SUB 421 421 TYR D 459 459 PHE C Protein S 2 FT #SUB 423 423 ARG D 382 382 ARG C Protein S 5 FT #SUB 423 423 ARG D 383 383 ARG C Protein S 6 FT #SUB 423 423 ARG D 385 385 ILE C Protein S 2 FT #SUB 423 423 ARG D 407 407 GLN C Protein A 11 FT #SUB 424 424 SER D 382 382 ARG C Protein S 2 FT #SUB 455 455 GLU D 212 212 MET C Protein S 5 FT #SUB 455 455 GLU D 215 215 ARG C Protein S 5 FT #SUB 455 455 GLU D 216 216 HIS C Protein S 4 FT #SUB 459 459 PHE D 267 267 GLY C Protein S 1 FT #SUB 459 459 PHE D 421 421 TYR C Protein S 2 FT #SUB 459 459 PHE D 459 459 PHE C Protein S 10 FT #SUB 460 460 ILE D 419 419 ASN C Protein B 1 FT #SUB 461 461 GLY D 407 407 GLN C Protein B 1 FT #SUB 461 461 GLY D 419 419 ASN C Protein B 1 FT #SUB 462 462 ASP D 382 382 ARG C Protein S 4 FT #SUB 462 462 ASP D 409 409 TYR C Protein S 2 FT #SUB 464 464 HIS D 382 382 ARG C Protein S 7 FT #SUB 466 466 TYR D 382 382 ARG C Protein S 3 FT #HET 9 9 VAL D 15 617 F89 D A 7 FT #HET 10 10 VAL D 15 617 F89 D B 10 FT #HET 10 10 VAL D 16 618 NDP D A 5 FT #HET 11 11 ALA D 15 617 F89 D A 6 FT #HET 11 11 ALA D 16 618 NDP D A 9 FT #HET 19 19 ILE D 16 618 NDP D A 12 FT #HET 20 20 GLY D 16 618 NDP D B 1 FT #HET 21 21 ILE D 16 618 NDP D B 1 FT #HET 23 23 GLY D 16 618 NDP D B 7 FT #HET 24 24 GLN D 16 618 NDP D B 7 FT #HET 25 25 LEU D 15 617 F89 D S 6 FT #HET 25 25 LEU D 16 618 NDP D A 5 FT #HET 32 32 ASP D 15 617 F89 D S 8 FT #HET 33 33 LEU D 15 617 F89 D A 8 FT #HET 36 36 PHE D 15 617 F89 D S 10 FT #HET 37 37 SER D 15 617 F89 D S 7 FT #HET 55 55 GLY D 16 618 NDP D B 10 FT #HET 56 56 ARG D 16 618 NDP D A 16 FT #HET 57 57 LYS D 16 618 NDP D A 16 FT #HET 58 58 THR D 16 618 NDP D A 11 FT #HET 61 61 SER D 16 618 NDP D S 1 FT #HET 62 62 ILE D 15 617 F89 D S 5 FT #HET 67 67 LEU D 15 617 F89 D S 3 FT #HET 70 70 ARG D 15 617 F89 D S 8 FT #HET 75 75 ILE D 16 618 NDP D A 9 FT #HET 76 76 SER D 16 618 NDP D A 9 FT #HET 77 77 SER D 16 618 NDP D A 7 FT #HET 78 78 SER D 16 618 NDP D A 2 FT #HET 92 92 ARG D 16 618 NDP D B 3 FT #HET 113 113 CYS D 15 617 F89 D B 3 FT #HET 113 113 CYS D 16 618 NDP D B 2 FT #HET 114 114 GLY D 16 618 NDP D B 2 FT #HET 115 115 GLY D 16 618 NDP D B 11 FT #HET 116 116 GLU D 16 618 NDP D A 6 FT #HET 117 117 SER D 16 618 NDP D A 8 FT #HET 118 118 ILE D 16 618 NDP D A 4 FT #HET 119 119 TYR D 15 617 F89 D S 1 FT #HET 119 119 TYR D 16 618 NDP D S 2 FT #HET 121 121 ASP D 16 618 NDP D S 1 FT #HET 134 134 THR D 15 617 F89 D S 2 FT #HET 145 145 THR D 16 618 NDP D S 4 FT #HET 257 257 ARG D 13 615 UMP D S 10 FT #HET 290 290 SER D 14 616 F89 D S 3 FT #HET 294 294 GLU D 14 616 F89 D S 4 FT #HET 315 315 ILE D 14 616 F89 D S 17 FT #HET 316 316 TRP D 14 616 F89 D S 3 FT #HET 319 319 ASN D 14 616 F89 D S 1 FT #HET 382 382 ARG D 9 611 UMP C S 9 FT #HET 383 383 ARG D 9 611 UMP C S 5 FT #HET 399 399 LEU D 13 615 UMP D S 1 FT #HET 402 402 CYS D 13 615 UMP D S 5 FT #HET 403 403 HIS D 13 615 UMP D S 2 FT #HET 422 422 GLN D 13 615 UMP D S 3 FT #HET 423 423 ARG D 13 615 UMP D S 6 FT #HET 424 424 SER D 13 615 UMP D A 6 FT #HET 425 425 CYS D 13 615 UMP D B 2 FT #HET 426 426 ASP D 13 615 UMP D A 6 FT #HET 426 426 ASP D 14 616 F89 D S 8 FT #HET 429 429 LEU D 14 616 F89 D S 1 FT #HET 430 430 GLY D 14 616 F89 D B 2 FT #HET 433 433 PHE D 14 616 F89 D S 32 FT #HET 434 434 ASN D 13 615 UMP D S 8 FT #HET 464 464 HIS D 13 615 UMP D S 5 FT #HET 466 466 TYR D 13 615 UMP D S 5 FT #HET 466 466 TYR D 14 616 F89 D S 3 FT #HET 519 519 MET D 14 616 F89 D S 6 FT #HET 520 520 ALA D 14 616 F89 D B 1 FT DISORDER 1 2 CC SEQUENCE 519 AA (ATOM); CC EKNVSIVVAA SVLSSGIGIN GQLPWSISED LKFFSKITNN KCDSNKKNAL IMGRKTWDSI CC GRRPLKNRII VVISSSLPQD EADPNVVVFR NLEDSIENLM NDDSIENIFV CGGESIYRDA CC LKDNFVDRIY LTRVALEDIE FDTYFPEIPE TFLPVYMSQT FCTKNISYDF MIFEKQEKKT CC LQNCDPARGQ LKSIDDTVDL LGEIFGIRKM GNRHKFPKEE IYNTPSIRFG REHYEFQYLD CC LLSRVLENGA YRENRTGIST YSIFGQMMRF DMRESFPLLT TKKVAIRSIF EELIWFIKGD CC TNGNHLIEKK VYIWSGNGSK EYLERIGLGH REENDLGPIY GFQWRHYNGE YKTMHDDYTG CC VGVDQLAKLI ETLKNNPKDR RHILTAWNPS ALSQMALPPC HVLSQYYVTN DNCLSCNLYQ CC RSCDLGLGSP FNIASYAILT MMLAQVCGYE PGELAIFIGD AHIYENHLTQ LKEQLSRTPR CC PFPQLKFKRK VENIEDFKWE DIELIGYYPY PTIKMDMAV CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSEKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKN CC ATOM --EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKN CC ************************************************ CC SEQRES ALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIEN CC ATOM ALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIEN CC ************************************************** CC SEQRES LMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEI CC ATOM LMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEI CC ************************************************** CC SEQRES PETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTV CC ATOM PETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTV CC ************************************************** CC SEQRES DLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLEN CC ATOM DLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLEN CC ************************************************** CC SEQRES GAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK CC ATOM GAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK CC ************************************************** CC SEQRES GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYN CC ATOM GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYN CC ************************************************** CC SEQRES GEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALP CC ATOM GEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALP CC ************************************************** CC SEQRES PCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCG CC ATOM PCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCG CC ************************************************** CC SEQRES YEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFK CC ATOM YEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFK CC ************************************************** CC SEQRES WEDIELIGYYPYPTIKMDMAV CC ATOM WEDIELIGYYPYPTIKMDMAV CC ********************* SQ SEQUENCE 521 AA; MW; CN; MSEKNVSIVV AASVLSSGIG INGQLPWSIS EDLKFFSKIT NNKCDSNKKN ALIMGRKTWD SIGRRPLKNR IIVVISSSLP QDEADPNVVV FRNLEDSIEN LMNDDSIENI FVCGGESIYR DALKDNFVDR IYLTRVALED IEFDTYFPEI PETFLPVYMS QTFCTKNISY DFMIFEKQEK KTLQNCDPAR GQLKSIDDTV DLLGEIFGIR KMGNRHKFPK EEIYNTPSIR FGREHYEFQY LDLLSRVLEN GAYRENRTGI STYSIFGQMM RFDMRESFPL LTTKKVAIRS IFEELIWFIK GDTNGNHLIE KKVYIWSGNG SKEYLERIGL GHREENDLGP IYGFQWRHYN GEYKTMHDDY TGVGVDQLAK LIETLKNNPK DRRHILTAWN PSALSQMALP PCHVLSQYYV TNDNCLSCNL YQRSCDLGLG SPFNIASYAI LTMMLAQVCG YEPGELAIFI GDAHIYENHL TQLKEQLSRT PRPFPQLKFK RKVENIEDFK WEDIELIGYY PYPTIKMDMA V // ID 1SEJE STANDARD; PRT; 521 AA. DT CONVERTED FROM PDB (SEQRES) 1SEJ DE bifunctional dihydrofolate reductase-thymidylate synthase OS Cryptosporidium hominis CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.870 CC R-Factor 0.220 FT #HET 9 9 VAL E 19 621 F89 E A 4 FT #HET 10 10 VAL E 19 621 F89 E B 6 FT #HET 10 10 VAL E 20 622 NDP E A 5 FT #HET 11 11 ALA E 19 621 F89 E A 6 FT #HET 11 11 ALA E 20 622 NDP E B 8 FT #HET 19 19 ILE E 20 622 NDP E A 13 FT #HET 20 20 GLY E 20 622 NDP E B 2 FT #HET 21 21 ILE E 20 622 NDP E B 1 FT #HET 23 23 GLY E 20 622 NDP E B 7 FT #HET 24 24 GLN E 20 622 NDP E B 6 FT #HET 25 25 LEU E 19 621 F89 E S 6 FT #HET 25 25 LEU E 20 622 NDP E A 5 FT #HET 32 32 ASP E 19 621 F89 E S 9 FT #HET 33 33 LEU E 19 621 F89 E A 6 FT #HET 36 36 PHE E 19 621 F89 E S 9 FT #HET 37 37 SER E 19 621 F89 E S 6 FT #HET 55 55 GLY E 20 622 NDP E B 10 FT #HET 56 56 ARG E 20 622 NDP E A 18 FT #HET 57 57 LYS E 20 622 NDP E A 15 FT #HET 58 58 THR E 20 622 NDP E A 11 FT #HET 61 61 SER E 20 622 NDP E S 1 FT #HET 62 62 ILE E 19 621 F89 E A 7 FT #HET 67 67 LEU E 19 621 F89 E S 3 FT #HET 70 70 ARG E 19 621 F89 E S 8 FT #HET 75 75 ILE E 20 622 NDP E A 14 FT #HET 76 76 SER E 20 622 NDP E A 12 FT #HET 77 77 SER E 20 622 NDP E A 7 FT #HET 78 78 SER E 20 622 NDP E A 2 FT #HET 92 92 ARG E 20 622 NDP E B 4 FT #HET 113 113 CYS E 19 621 F89 E B 2 FT #HET 113 113 CYS E 20 622 NDP E B 2 FT #HET 114 114 GLY E 20 622 NDP E B 2 FT #HET 115 115 GLY E 20 622 NDP E B 9 FT #HET 116 116 GLU E 20 622 NDP E A 5 FT #HET 117 117 SER E 20 622 NDP E A 7 FT #HET 118 118 ILE E 20 622 NDP E S 3 FT #HET 119 119 TYR E 20 622 NDP E S 2 FT #HET 121 121 ASP E 20 622 NDP E S 1 FT #HET 134 134 THR E 19 621 F89 E S 2 FT #HET 145 145 THR E 20 622 NDP E S 5 FT #HET 257 257 ARG E 17 619 UMP E S 9 FT #HET 290 290 SER E 18 620 F89 E S 1 FT #HET 294 294 GLU E 18 620 F89 E S 2 FT #HET 314 314 TYR E 18 620 F89 E B 2 FT #HET 315 315 ILE E 18 620 F89 E A 17 FT #HET 316 316 TRP E 18 620 F89 E S 2 FT #HET 319 319 ASN E 18 620 F89 E S 1 FT #HET 399 399 LEU E 17 619 UMP E S 1 FT #HET 399 399 LEU E 18 620 F89 E S 1 FT #HET 402 402 CYS E 17 619 UMP E S 8 FT #HET 403 403 HIS E 17 619 UMP E S 2 FT #HET 422 422 GLN E 17 619 UMP E S 3 FT #HET 423 423 ARG E 17 619 UMP E S 6 FT #HET 424 424 SER E 17 619 UMP E A 8 FT #HET 425 425 CYS E 17 619 UMP E B 2 FT #HET 426 426 ASP E 17 619 UMP E A 5 FT #HET 426 426 ASP E 18 620 F89 E S 4 FT #HET 429 429 LEU E 18 620 F89 E S 1 FT #HET 430 430 GLY E 18 620 F89 E B 5 FT #HET 433 433 PHE E 18 620 F89 E S 20 FT #HET 434 434 ASN E 17 619 UMP E S 8 FT #HET 464 464 HIS E 17 619 UMP E S 4 FT #HET 466 466 TYR E 17 619 UMP E S 4 FT #HET 466 466 TYR E 18 620 F89 E S 1 FT #HET 517 517 MET E 18 620 F89 E B 1 FT #HET 519 519 MET E 18 620 F89 E S 3 FT #HET 520 520 ALA E 18 620 F89 E B 1 FT DISORDER 1 2 CC SEQUENCE 519 AA (ATOM); CC EKNVSIVVAA SVLSSGIGIN GQLPWSISED LKFFSKITNN KCDSNKKNAL IMGRKTWDSI CC GRRPLKNRII VVISSSLPQD EADPNVVVFR NLEDSIENLM NDDSIENIFV CGGESIYRDA CC LKDNFVDRIY LTRVALEDIE FDTYFPEIPE TFLPVYMSQT FCTKNISYDF MIFEKQEKKT CC LQNCDPARGQ LKSIDDTVDL LGEIFGIRKM GNRHKFPKEE IYNTPSIRFG REHYEFQYLD CC LLSRVLENGA YRENRTGIST YSIFGQMMRF DMRESFPLLT TKKVAIRSIF EELIWFIKGD CC TNGNHLIEKK VYIWSGNGSK EYLERIGLGH REENDLGPIY GFQWRHYNGE YKTMHDDYTG CC VGVDQLAKLI ETLKNNPKDR RHILTAWNPS ALSQMALPPC HVLSQYYVTN DNCLSCNLYQ CC RSCDLGLGSP FNIASYAILT MMLAQVCGYE PGELAIFIGD AHIYENHLTQ LKEQLSRTPR CC PFPQLKFKRK VENIEDFKWE DIELIGYYPY PTIKMDMAV CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSEKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKN CC ATOM --EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKN CC ************************************************ CC SEQRES ALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIEN CC ATOM ALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIEN CC ************************************************** CC SEQRES LMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEI CC ATOM LMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEI CC ************************************************** CC SEQRES PETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTV CC ATOM PETFLPVYMSQTFCTKNISYDFMIFEKQEKKTLQNCDPARGQLKSIDDTV CC ************************************************** CC SEQRES DLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLEN CC ATOM DLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLEN CC ************************************************** CC SEQRES GAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK CC ATOM GAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK CC ************************************************** CC SEQRES GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYN CC ATOM GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYN CC ************************************************** CC SEQRES GEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALP CC ATOM GEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALP CC ************************************************** CC SEQRES PCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCG CC ATOM PCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCG CC ************************************************** CC SEQRES YEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFK CC ATOM YEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFK CC ************************************************** CC SEQRES WEDIELIGYYPYPTIKMDMAV CC ATOM WEDIELIGYYPYPTIKMDMAV CC ********************* SQ SEQUENCE 521 AA; MW; CN; MSEKNVSIVV AASVLSSGIG INGQLPWSIS EDLKFFSKIT NNKCDSNKKN ALIMGRKTWD SIGRRPLKNR IIVVISSSLP QDEADPNVVV FRNLEDSIEN LMNDDSIENI FVCGGESIYR DALKDNFVDR IYLTRVALED IEFDTYFPEI PETFLPVYMS QTFCTKNISY DFMIFEKQEK KTLQNCDPAR GQLKSIDDTV DLLGEIFGIR KMGNRHKFPK EEIYNTPSIR FGREHYEFQY LDLLSRVLEN GAYRENRTGI STYSIFGQMM RFDMRESFPL LTTKKVAIRS IFEELIWFIK GDTNGNHLIE KKVYIWSGNG SKEYLERIGL GHREENDLGP IYGFQWRHYN GEYKTMHDDY TGVGVDQLAK LIETLKNNPK DRRHILTAWN PSALSQMALP PCHVLSQYYV TNDNCLSCNL YQRSCDLGLG SPFNIASYAI LTMMLAQVCG YEPGELAIFI GDAHIYENHL TQLKEQLSRT PRPFPQLKFK RKVENIEDFK WEDIELIGYY PYPTIKMDMA V //