Het-PDB Navi2 (PDB: 1Q8J)

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Ligands
Code	Name	Link
CD	Cadmium ion	PoSSuM
HCS	2-amino-4-mercapto-butyric acid	PoSSuM
C2F	5-methyl-5,6,7,8-tetrahydrofolic acid	PoSSuM

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Download interaction data: 1Q8J

Code :

1Q8J PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima (Cd2+, Hcy, methyltetrahydrofolate complex)

Release Data :

2004-03-23

Compound :

mol_id	molecule	chains
1	5-methyltetrahydrofolate S-homocysteine methyltransferase	A,B
	ec: 2.1.1.13 fragment: MetH_Tm (residues 1-566)

Source :

mol_id	organism_scientific	expression_system
1	Thermotoga maritima (taxid:2336)	Escherichia coli BL21(DE3) (taxid:469008)
	expression_system_strain: BL21-DE3 expression_system_vector_type: plasmid expression_system_plasmid: pET29a

Authors :

Evans, J.C., Huddler, D.P., Hilgers, M.T., Romanchuk, G., Matthews, R.G., Ludwig, M.L.

Keywords :

homocysteine, methionine, folate, cobalamin, vitamin b12, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase.

Evans, J.C.,Huddler, D.P.,Hilgers, M.T. et al.
(2004) Proc.Natl.Acad.Sci.Usa 101 : 3729 - 3736

Chain :

A, B

UniProt :

Q9WYA5 (Q9WYA5_THEMA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine	2.1.1.13	ARBA:ARBA00001700
	-	ARBA:ARBA00001700

PDB ID: 1Q8J