Brand  (β version)

PDB ID: 1NXK

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
STU Staurosporine PoSSuM
Non-standard Residues
Code Name Show
MSE Selenomethionine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1NXK   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of staurosporine bound to MAP KAP kinase 2
Release Data : 2003-10-14
Compound :
mol_id molecule chains synonym
1 MAP kinase-activated protein kinase 2 A,B,C,D MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2
ec: 2.7.1.-
fragment: MK2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: MAPKAPK2
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET16b
Authors : Underwood, K.W., Parris, K.D., Federico, E., Mosyak, L., Czerwinski, R.M., Shane, T., Taylor, M., Svenson, K., Liu, Y., Hsiao, C.L., Wolfrom, S., Malakian, K., Telliez, J.B., Lin, L.L., Kriz, R.W., Seehra, J., Somers, W.S., Stahl, M.L.
Keywords : protein kinase, mk2, phosphorylation, staurosporine, transferase
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme

Underwood, K.W.,Parris, K.D.,Federico, E.  et al.
(2003)  Structure  11 : 627 - 636

PubMed: 12791252
DOI: 10.1016/S0969-2126(03)00092-3

Reaction

Chain : A, B, C, D
UniProt : P49137 (MAPK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12171911, PubMed:8774846
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:12171911, PubMed:8774846
-