ID 1NXKA STANDARD; PRT; 400 AA. DT CONVERTED FROM PDB (SEQRES) 1NXK DE MAP kinase-activated protein kinase 2 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.700 CC R-Factor 0.239 FT #SUB 53 53 GLN A 53 53 GLN B Protein S 1 FT #SUB 56 56 LYS A 50 50 SER B Protein B 4 FT #SUB 56 56 LYS A 51 51 GLY B Protein A 6 FT #SUB 56 56 LYS A 52 52 LEU B Protein S 1 FT #SUB 56 56 LYS A 53 53 GLN B Protein S 7 FT #SUB 57 57 ASN A 50 50 SER B Protein B 2 FT #SUB 58 58 ALA A 50 50 SER B Protein B 3 FT #SUB 60 60 ILE A 45 45 GLN B Protein S 1 FT #SUB 60 60 ILE A 48 48 VAL B Protein S 1 FT #SUB 65 65 VAL A 45 45 GLN B Protein S 6 FT #SUB 94 94 MSE A 45 45 GLN B Protein S 1 FT #SUB 125 125 GLU A 51 51 GLY B Protein B 2 FT #SUB 126 126 ASN A 49 49 LYS B Protein A 4 FT #SUB 126 126 ASN A 50 50 SER B Protein S 1 FT #SUB 126 126 ASN A 51 51 GLY B Protein A 2 FT #SUB 127 127 LEU A 47 47 HIS B Protein B 1 FT #SUB 127 127 LEU A 48 48 VAL B Protein B 2 FT #SUB 127 127 LEU A 49 49 LYS B Protein A 14 FT #SUB 127 127 LEU A 50 50 SER B Protein S 1 FT #SUB 127 127 LEU A 109 109 TRP B Protein S 2 FT #SUB 127 127 LEU A 110 110 ARG B Protein S 2 FT #SUB 128 128 TYR A 45 45 GLN B Protein S 1 FT #SUB 128 128 TYR A 47 47 HIS B Protein A 7 FT #SUB 129 129 ALA A 47 47 HIS B Protein B 5 FT #SUB 130 130 GLY A 110 110 ARG B Protein B 5 FT #SUB 130 130 GLY A 180 180 ILE B Protein B 1 FT #SUB 132 132 LYS A 106 106 GLU B Protein S 4 FT #SUB 42 42 GLN A 67 67 SER C Protein S 3 FT #SUB 43 43 PHE A 65 65 VAL C Protein S 6 FT #SUB 43 43 PHE A 66 66 THR C Protein S 1 FT #SUB 43 43 PHE A 79 79 LEU C Protein S 2 FT #SUB 44 44 PRO A 128 128 TYR C Protein A 6 FT #SUB 45 45 GLN A 60 60 ILE C Protein A 4 FT #SUB 45 45 GLN A 64 64 LYS C Protein S 4 FT #SUB 45 45 GLN A 65 65 VAL C Protein S 4 FT #SUB 47 47 HIS A 127 127 LEU C Protein B 1 FT #SUB 47 47 HIS A 128 128 TYR C Protein A 6 FT #SUB 47 47 HIS A 129 129 ALA C Protein A 4 FT #SUB 48 48 VAL A 60 60 ILE C Protein B 1 FT #SUB 48 48 VAL A 126 126 ASN C Protein S 1 FT #SUB 48 48 VAL A 127 127 LEU C Protein B 2 FT #SUB 48 48 VAL A 128 128 TYR C Protein S 2 FT #SUB 49 49 LYS A 126 126 ASN C Protein B 5 FT #SUB 49 49 LYS A 127 127 LEU C Protein A 11 FT #SUB 50 50 SER A 56 56 LYS C Protein A 5 FT #SUB 50 50 SER A 57 57 ASN C Protein A 3 FT #SUB 50 50 SER A 58 58 ALA C Protein A 7 FT #SUB 50 50 SER A 126 126 ASN C Protein B 1 FT #SUB 51 51 GLY A 56 56 LYS C Protein B 9 FT #SUB 51 51 GLY A 125 125 GLU C Protein B 2 FT #SUB 51 51 GLY A 126 126 ASN C Protein B 2 FT #SUB 52 52 LEU A 56 56 LYS C Protein B 1 FT #SUB 53 53 GLN A 56 56 LYS C Protein A 6 FT #SUB 106 106 GLU A 132 132 LYS C Protein S 5 FT #SUB 109 109 TRP A 127 127 LEU C Protein S 2 FT #SUB 110 110 ARG A 127 127 LEU C Protein S 4 FT #SUB 110 110 ARG A 130 130 GLY C Protein S 3 FT #SUB 176 176 TYR A 130 130 GLY C Protein S 1 FT #SUB 179 179 SER A 131 131 ARG C Protein B 1 FT #SUB 180 180 ILE A 129 129 ALA C Protein S 1 FT #SUB 180 180 ILE A 130 130 GLY C Protein S 1 FT #SUB 180 180 ILE A 131 131 ARG C Protein B 3 FT #SUB 44 44 PRO A 267 267 HIS D Protein S 4 FT #SUB 46 46 PHE A 267 267 HIS D Protein S 2 FT #SUB 46 46 PHE A 268 268 GLY D Protein S 4 FT #SUB 46 46 PHE A 269 269 LEU D Protein S 2 FT #SUB 47 47 HIS A 267 267 HIS D Protein S 2 FT #SUB 47 47 HIS A 269 269 LEU D Protein S 5 FT #SUB 47 47 HIS A 270 270 ALA D Protein S 3 FT #SUB 47 47 HIS A 273 273 PRO D Protein S 4 FT #SUB 175 175 GLN A 271 271 ILE D Protein S 1 FT #SUB 175 175 GLN A 281 281 MSE D Protein B 1 FT #SUB 176 176 TYR A 271 271 ILE D Protein S 1 FT #SUB 178 178 HIS A 281 281 MSE D Protein B 4 FT #SUB 179 179 SER A 272 272 SER D Protein S 1 FT #SUB 179 179 SER A 277 277 THR D Protein B 1 FT #SUB 179 179 SER A 281 281 MSE D Protein A 5 FT #SUB 228 228 TYR A 189 189 PRO D Protein S 2 FT #SUB 228 228 TYR A 190 190 GLU D Protein S 5 FT #SUB 228 228 TYR A 255 255 ILE D Protein S 1 FT #SUB 228 228 TYR A 261 261 PRO D Protein S 1 FT #SUB 229 229 TYR A 186 186 ASP D Protein S 1 FT #SUB 229 229 TYR A 188 188 LYS D Protein S 6 FT #SUB 229 229 TYR A 247 247 TRP D Protein B 2 FT #SUB 229 229 TYR A 248 248 SER D Protein B 1 FT #SUB 230 230 VAL A 247 247 TRP D Protein B 2 FT #SUB 230 230 VAL A 279 279 ILE D Protein A 3 FT #SUB 231 231 ALA A 244 244 CYS D Protein S 1 FT #SUB 231 231 ALA A 247 247 TRP D Protein A 9 FT #SUB 232 232 PRO A 247 247 TRP D Protein S 6 FT #SUB 232 232 PRO A 279 279 ILE D Protein B 2 FT #SUB 232 232 PRO A 280 280 ARG D Protein S 1 FT #SUB 232 232 PRO A 308 308 THR D Protein S 3 FT #SUB 233 233 GLU A 244 244 CYS D Protein S 1 FT #SUB 233 233 GLU A 310 310 PRO D Protein S 5 FT #SUB 233 233 GLU A 313 313 ARG D Protein S 5 FT #SUB 235 235 LEU A 280 280 ARG D Protein B 4 FT #SUB 240 240 TYR A 309 309 GLU D Protein S 8 FT #SUB 311 311 THR A 309 309 GLU D Protein S 3 FT #SUB 311 311 THR A 311 311 THR D Protein S 2 FT #SUB 311 311 THR A 312 312 GLN D Protein B 4 FT #SUB 312 312 GLN A 312 312 GLN D Protein B 1 FT #SUB 317 317 THR A 281 281 MSE D Protein S 2 FT #SUB 318 318 GLU A 307 307 LYS D Protein S 1 FT #HET 53 53 GLN A 3 402 SO4 B S 3 FT #HET 70 70 LEU A 1 401 STU A A 12 FT #HET 71 71 GLY A 1 401 STU A B 4 FT #HET 72 72 LEU A 1 401 STU A B 3 FT #HET 73 73 GLY A 1 401 STU A B 2 FT #HET 78 78 VAL A 1 401 STU A S 5 FT #HET 91 91 ALA A 1 401 STU A S 5 FT #HET 118 118 VAL A 1 401 STU A S 1 FT #HET 138 138 MSE A 1 401 STU A S 4 FT #HET 139 139 GLU A 1 401 STU A B 4 FT #HET 140 140 CYS A 1 401 STU A A 3 FT #HET 141 141 LEU A 1 401 STU A A 18 FT #HET 190 190 GLU A 1 401 STU A A 4 FT #HET 191 191 ASN A 1 401 STU A A 3 FT #HET 193 193 LEU A 1 401 STU A S 4 FT #HET 206 206 THR A 1 401 STU A S 3 FT #HET 207 207 ASP A 1 401 STU A A 11 FT DISORDER 1 41 FT DISORDER 154 156 FT DISORDER 216 226 FT DISORDER 346 400 CC SEQUENCE 290 AA (ATOM); CC QFPQFHVKSG LQIKKNAIID DYKVTSQVLG LGINGKVLQI FNKRTQEKFA LKMLQDCPKA CC RREVELHWRA SQCPHIVRIV DVYENLYAGR KCLLIVMECL DGGELFSRIQ DRAFTEREAS CC EIMKSIGEAI QYLHSINIAH RDVKPENLLY TSKRPNAILK LTDFGFAKET TPYYVAPEVL CC GPEKYDKSCD MWSLGVIMYI LLCGYPPFYS NHGLAISPGM KTRIRMGQYE FPNPEWSEVS CC EEVKMLIRNL LKTEPTQRMT ITEFMNHPWI MQSTKVPQTP LHTSRVLKED CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKS CC ATOM -----------------------------------------QFPQFHVKS CC ********* CC SEQRES GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK CC ATOM GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK CC ************************************************** CC SEQRES ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI CC ATOM ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI CC ************************************************** CC SEQRES QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN CC ATOM QDR---AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN CC *** ******************************************** CC SEQRES AILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG CC ATOM AILKLTDFGFAKETT-----------PYYVAPEVLGPEKYDKSCDMWSLG CC *************** ************************ CC SEQRES VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM CC ATOM VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM CC ************************************************** CC SEQRES LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE CC ATOM LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED----- CC ********************************************* CC SEQRES DVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH CC ATOM -------------------------------------------------- CC CC SEQRES CC ATOM CC SQ SEQUENCE 400 AA; MW; CN; MLSNSQGQSP PVPFPAPAPP PQPPTPALPH PPAQPPPPPP QQFPQFHVKS GLQIKKNAII DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK ARREVELHWR ASQCPHIVRI VDVYENLYAG RKCLLIVMEC LDGGELFSRI QDRGDQAFTE REASEIMKSI GEAIQYLHSI NIAHRDVKPE NLLYTSKRPN AILKLTDFGF AKETTSHNSL TTPCYTPYYV APEVLGPEKY DKSCDMWSLG VIMYILLCGY PPFYSNHGLA ISPGMKTRIR MGQYEFPNPE WSEVSEEVKM LIRNLLKTEP TQRMTITEFM NHPWIMQSTK VPQTPLHTSR VLKEDKERWE DVKEEMTSAL ATMRVDYEQI KIKKIEDASN PLLLKRRKKA RALEAAALAH // ID 1NXKB STANDARD; PRT; 400 AA. DT CONVERTED FROM PDB (SEQRES) 1NXK DE MAP kinase-activated protein kinase 2 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.700 CC R-Factor 0.239 FT #SUB 45 45 GLN B 60 60 ILE A Protein S 1 FT #SUB 45 45 GLN B 65 65 VAL A Protein S 6 FT #SUB 45 45 GLN B 94 94 MSE A Protein S 1 FT #SUB 45 45 GLN B 128 128 TYR A Protein S 1 FT #SUB 47 47 HIS B 127 127 LEU A Protein B 1 FT #SUB 47 47 HIS B 128 128 TYR A Protein A 7 FT #SUB 47 47 HIS B 129 129 ALA A Protein A 5 FT #SUB 48 48 VAL B 60 60 ILE A Protein B 1 FT #SUB 48 48 VAL B 127 127 LEU A Protein B 2 FT #SUB 49 49 LYS B 126 126 ASN A Protein B 4 FT #SUB 49 49 LYS B 127 127 LEU A Protein A 14 FT #SUB 50 50 SER B 56 56 LYS A Protein A 4 FT #SUB 50 50 SER B 57 57 ASN A Protein S 2 FT #SUB 50 50 SER B 58 58 ALA A Protein A 3 FT #SUB 50 50 SER B 126 126 ASN A Protein B 1 FT #SUB 50 50 SER B 127 127 LEU A Protein B 1 FT #SUB 51 51 GLY B 56 56 LYS A Protein B 6 FT #SUB 51 51 GLY B 125 125 GLU A Protein B 2 FT #SUB 51 51 GLY B 126 126 ASN A Protein B 2 FT #SUB 52 52 LEU B 56 56 LYS A Protein B 1 FT #SUB 53 53 GLN B 53 53 GLN A Protein S 1 FT #SUB 53 53 GLN B 56 56 LYS A Protein A 7 FT #SUB 106 106 GLU B 132 132 LYS A Protein S 4 FT #SUB 109 109 TRP B 127 127 LEU A Protein S 2 FT #SUB 110 110 ARG B 127 127 LEU A Protein S 2 FT #SUB 110 110 ARG B 130 130 GLY A Protein S 5 FT #SUB 180 180 ILE B 130 130 GLY A Protein S 1 FT #SUB 56 56 LYS B 50 50 SER C Protein B 5 FT #SUB 56 56 LYS B 51 51 GLY C Protein A 7 FT #SUB 56 56 LYS B 52 52 LEU C Protein S 6 FT #SUB 56 56 LYS B 53 53 GLN C Protein S 8 FT #SUB 57 57 ASN B 50 50 SER C Protein B 2 FT #SUB 58 58 ALA B 50 50 SER C Protein A 4 FT #SUB 59 59 ILE B 48 48 VAL C Protein S 1 FT #SUB 60 60 ILE B 45 45 GLN C Protein S 5 FT #SUB 60 60 ILE B 48 48 VAL C Protein S 1 FT #SUB 65 65 VAL B 41 41 GLN C Protein B 2 FT #SUB 65 65 VAL B 45 45 GLN C Protein B 2 FT #SUB 66 66 THR B 41 41 GLN C Protein B 2 FT #SUB 66 66 THR B 42 42 GLN C Protein B 1 FT #SUB 67 67 SER B 42 42 GLN C Protein A 7 FT #SUB 67 67 SER B 43 43 PHE C Protein S 2 FT #SUB 125 125 GLU B 51 51 GLY C Protein B 2 FT #SUB 126 126 ASN B 48 48 VAL C Protein S 1 FT #SUB 126 126 ASN B 49 49 LYS C Protein A 5 FT #SUB 126 126 ASN B 50 50 SER C Protein S 1 FT #SUB 126 126 ASN B 51 51 GLY C Protein S 1 FT #SUB 127 127 LEU B 47 47 HIS C Protein B 1 FT #SUB 127 127 LEU B 48 48 VAL C Protein B 2 FT #SUB 127 127 LEU B 49 49 LYS C Protein A 11 FT #SUB 127 127 LEU B 109 109 TRP C Protein S 2 FT #SUB 127 127 LEU B 110 110 ARG C Protein S 2 FT #SUB 128 128 TYR B 44 44 PRO C Protein S 2 FT #SUB 128 128 TYR B 47 47 HIS C Protein A 6 FT #SUB 128 128 TYR B 48 48 VAL C Protein S 2 FT #SUB 129 129 ALA B 47 47 HIS C Protein B 4 FT #SUB 130 130 GLY B 110 110 ARG C Protein B 6 FT #HET 53 53 GLN B 3 402 SO4 B S 6 FT #HET 56 56 LYS B 3 402 SO4 B S 2 FT #HET 70 70 LEU B 4 403 STU B A 13 FT #HET 71 71 GLY B 4 403 STU B B 4 FT #HET 72 72 LEU B 4 403 STU B B 3 FT #HET 73 73 GLY B 4 403 STU B B 2 FT #HET 78 78 VAL B 4 403 STU B S 4 FT #HET 91 91 ALA B 4 403 STU B S 5 FT #HET 93 93 LYS B 4 403 STU B S 2 FT #HET 138 138 MSE B 4 403 STU B S 4 FT #HET 139 139 GLU B 4 403 STU B B 5 FT #HET 140 140 CYS B 4 403 STU B A 3 FT #HET 141 141 LEU B 4 403 STU B A 14 FT #HET 190 190 GLU B 4 403 STU B B 2 FT #HET 191 191 ASN B 4 403 STU B A 2 FT #HET 193 193 LEU B 4 403 STU B S 5 FT #HET 195 195 THR B 2 401 SO4 B A 5 FT #HET 196 196 SER B 2 401 SO4 B A 8 FT #HET 198 198 ARG B 2 401 SO4 B S 2 FT #HET 206 206 THR B 4 403 STU B S 2 FT #HET 207 207 ASP B 4 403 STU B A 11 FT DISORDER 1 43 FT DISORDER 216 226 FT DISORDER 266 273 FT DISORDER 346 400 CC SEQUENCE 283 AA (ATOM); CC PQFHVKSGLQ IKKNAIIDDY KVTSQVLGLG INGKVLQIFN KRTQEKFALK MLQDCPKARR CC EVELHWRASQ CPHIVRIVDV YENLYAGRKC LLIVMECLDG GELFSRIQDR GDQAFTEREA CC SEIMKSIGEA IQYLHSINIA HRDVKPENLL YTSKRPNAIL KLTDFGFAKE TTPYYVAPEV CC LGPEKYDKSC DMWSLGVIMY ILLCGYPPFY SGMKTRIRMG QYEFPNPEWS EVSEEVKMLI CC RNLLKTEPTQ RMTITEFMNH PWIMQSTKVP QTPLHTSRVL KED CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKS CC ATOM -------------------------------------------PQFHVKS CC ******* CC SEQRES GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK CC ATOM GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK CC ************************************************** CC SEQRES ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI CC ATOM ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI CC ************************************************** CC SEQRES QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN CC ATOM QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN CC ************************************************** CC SEQRES AILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG CC ATOM AILKLTDFGFAKETT-----------PYYVAPEVLGPEKYDKSCDMWSLG CC *************** ************************ CC SEQRES VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM CC ATOM VIMYILLCGYPPFYS--------GMKTRIRMGQYEFPNPEWSEVSEEVKM CC *************** *************************** CC SEQRES LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE CC ATOM LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED----- CC ********************************************* CC SEQRES DVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH CC ATOM -------------------------------------------------- CC CC SEQRES CC ATOM CC SQ SEQUENCE 400 AA; MW; CN; MLSNSQGQSP PVPFPAPAPP PQPPTPALPH PPAQPPPPPP QQFPQFHVKS GLQIKKNAII DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK ARREVELHWR ASQCPHIVRI VDVYENLYAG RKCLLIVMEC LDGGELFSRI QDRGDQAFTE REASEIMKSI GEAIQYLHSI NIAHRDVKPE NLLYTSKRPN AILKLTDFGF AKETTSHNSL TTPCYTPYYV APEVLGPEKY DKSCDMWSLG VIMYILLCGY PPFYSNHGLA ISPGMKTRIR MGQYEFPNPE WSEVSEEVKM LIRNLLKTEP TQRMTITEFM NHPWIMQSTK VPQTPLHTSR VLKEDKERWE DVKEEMTSAL ATMRVDYEQI KIKKIEDASN PLLLKRRKKA RALEAAALAH // ID 1NXKC STANDARD; PRT; 400 AA. DT CONVERTED FROM PDB (SEQRES) 1NXK DE MAP kinase-activated protein kinase 2 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.700 CC R-Factor 0.239 FT #SUB 56 56 LYS C 50 50 SER A Protein B 5 FT #SUB 56 56 LYS C 51 51 GLY A Protein A 9 FT #SUB 56 56 LYS C 52 52 LEU A Protein S 1 FT #SUB 56 56 LYS C 53 53 GLN A Protein S 6 FT #SUB 57 57 ASN C 50 50 SER A Protein B 3 FT #SUB 58 58 ALA C 50 50 SER A Protein A 7 FT #SUB 60 60 ILE C 45 45 GLN A Protein S 4 FT #SUB 60 60 ILE C 48 48 VAL A Protein S 1 FT #SUB 64 64 LYS C 45 45 GLN A Protein A 4 FT #SUB 65 65 VAL C 43 43 PHE A Protein A 6 FT #SUB 65 65 VAL C 45 45 GLN A Protein B 4 FT #SUB 66 66 THR C 43 43 PHE A Protein B 1 FT #SUB 67 67 SER C 42 42 GLN A Protein S 3 FT #SUB 79 79 LEU C 43 43 PHE A Protein S 2 FT #SUB 125 125 GLU C 51 51 GLY A Protein B 2 FT #SUB 126 126 ASN C 48 48 VAL A Protein S 1 FT #SUB 126 126 ASN C 49 49 LYS A Protein A 5 FT #SUB 126 126 ASN C 50 50 SER A Protein S 1 FT #SUB 126 126 ASN C 51 51 GLY A Protein A 2 FT #SUB 127 127 LEU C 47 47 HIS A Protein B 1 FT #SUB 127 127 LEU C 48 48 VAL A Protein B 2 FT #SUB 127 127 LEU C 49 49 LYS A Protein A 11 FT #SUB 127 127 LEU C 109 109 TRP A Protein S 2 FT #SUB 127 127 LEU C 110 110 ARG A Protein S 4 FT #SUB 128 128 TYR C 44 44 PRO A Protein S 6 FT #SUB 128 128 TYR C 47 47 HIS A Protein A 6 FT #SUB 128 128 TYR C 48 48 VAL A Protein S 2 FT #SUB 129 129 ALA C 47 47 HIS A Protein B 4 FT #SUB 129 129 ALA C 180 180 ILE A Protein B 1 FT #SUB 130 130 GLY C 110 110 ARG A Protein B 3 FT #SUB 130 130 GLY C 176 176 TYR A Protein B 1 FT #SUB 130 130 GLY C 180 180 ILE A Protein B 1 FT #SUB 131 131 ARG C 179 179 SER A Protein S 1 FT #SUB 131 131 ARG C 180 180 ILE A Protein S 3 FT #SUB 132 132 LYS C 106 106 GLU A Protein S 5 FT #SUB 41 41 GLN C 65 65 VAL B Protein B 2 FT #SUB 41 41 GLN C 66 66 THR B Protein B 2 FT #SUB 42 42 GLN C 66 66 THR B Protein S 1 FT #SUB 42 42 GLN C 67 67 SER B Protein A 7 FT #SUB 43 43 PHE C 67 67 SER B Protein S 2 FT #SUB 44 44 PRO C 128 128 TYR B Protein A 2 FT #SUB 45 45 GLN C 60 60 ILE B Protein A 5 FT #SUB 45 45 GLN C 65 65 VAL B Protein S 2 FT #SUB 47 47 HIS C 127 127 LEU B Protein B 1 FT #SUB 47 47 HIS C 128 128 TYR B Protein A 6 FT #SUB 47 47 HIS C 129 129 ALA B Protein A 4 FT #SUB 48 48 VAL C 59 59 ILE B Protein S 1 FT #SUB 48 48 VAL C 60 60 ILE B Protein B 1 FT #SUB 48 48 VAL C 126 126 ASN B Protein S 1 FT #SUB 48 48 VAL C 127 127 LEU B Protein B 2 FT #SUB 48 48 VAL C 128 128 TYR B Protein S 2 FT #SUB 49 49 LYS C 126 126 ASN B Protein B 5 FT #SUB 49 49 LYS C 127 127 LEU B Protein A 11 FT #SUB 50 50 SER C 56 56 LYS B Protein A 5 FT #SUB 50 50 SER C 57 57 ASN B Protein S 2 FT #SUB 50 50 SER C 58 58 ALA B Protein A 4 FT #SUB 50 50 SER C 126 126 ASN B Protein B 1 FT #SUB 51 51 GLY C 56 56 LYS B Protein B 7 FT #SUB 51 51 GLY C 125 125 GLU B Protein B 2 FT #SUB 51 51 GLY C 126 126 ASN B Protein B 1 FT #SUB 52 52 LEU C 56 56 LYS B Protein B 6 FT #SUB 53 53 GLN C 56 56 LYS B Protein A 8 FT #SUB 109 109 TRP C 127 127 LEU B Protein S 2 FT #SUB 110 110 ARG C 127 127 LEU B Protein A 2 FT #SUB 110 110 ARG C 130 130 GLY B Protein S 6 FT #SUB 128 128 TYR C 267 267 HIS D Protein S 5 FT #SUB 131 131 ARG C 277 277 THR D Protein S 1 FT #SUB 267 267 HIS C 128 128 TYR D Protein S 4 FT #SUB 357 357 THR C 72 72 LEU D Protein S 3 FT #HET 53 53 GLN C 3 402 SO4 B S 5 FT #HET 70 70 LEU C 5 401 STU C A 7 FT #HET 71 71 GLY C 5 401 STU C B 5 FT #HET 72 72 LEU C 5 401 STU C B 3 FT #HET 73 73 GLY C 5 401 STU C B 3 FT #HET 78 78 VAL C 5 401 STU C S 4 FT #HET 91 91 ALA C 5 401 STU C S 3 FT #HET 118 118 VAL C 5 401 STU C S 1 FT #HET 138 138 MSE C 5 401 STU C S 4 FT #HET 139 139 GLU C 5 401 STU C B 5 FT #HET 140 140 CYS C 5 401 STU C A 6 FT #HET 141 141 LEU C 5 401 STU C A 8 FT #HET 145 145 GLU C 5 401 STU C S 1 FT #HET 190 190 GLU C 5 401 STU C A 5 FT #HET 191 191 ASN C 5 401 STU C A 2 FT #HET 193 193 LEU C 5 401 STU C S 6 FT #HET 206 206 THR C 5 401 STU C S 2 FT #HET 207 207 ASP C 5 401 STU C A 10 FT DISORDER 1 40 FT DISORDER 216 226 FT DISORDER 358 400 CC SEQUENCE 306 AA (ATOM); CC QQFPQFHVKS GLQIKKNAII DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK CC ARREVELHWR ASQCPHIVRI VDVYENLYAG RKCLLIVMEC LDGGELFSRI QDRGDQAFTE CC REASEIMKSI GEAIQYLHSI NIAHRDVKPE NLLYTSKRPN AILKLTDFGF AKETTPYYVA CC PEVLGPEKYD KSCDMWSLGV IMYILLCGYP PFYSNHGLAI SPGMKTRIRM GQYEFPNPEW CC SEVSEEVKML IRNLLKTEPT QRMTITEFMN HPWIMQSTKV PQTPLHTSRV LKEDKERWED CC VKEEMT CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKS CC ATOM ----------------------------------------QQFPQFHVKS CC ********** CC SEQRES GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK CC ATOM GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK CC ************************************************** CC SEQRES ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI CC ATOM ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI CC ************************************************** CC SEQRES QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN CC ATOM QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN CC ************************************************** CC SEQRES AILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG CC ATOM AILKLTDFGFAKETT-----------PYYVAPEVLGPEKYDKSCDMWSLG CC *************** ************************ CC SEQRES VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM CC ATOM VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM CC ************************************************** CC SEQRES LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE CC ATOM LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE CC ************************************************** CC SEQRES DVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH CC ATOM DVKEEMT------------------------------------------- CC ******* CC SEQRES CC ATOM CC SQ SEQUENCE 400 AA; MW; CN; MLSNSQGQSP PVPFPAPAPP PQPPTPALPH PPAQPPPPPP QQFPQFHVKS GLQIKKNAII DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK ARREVELHWR ASQCPHIVRI VDVYENLYAG RKCLLIVMEC LDGGELFSRI QDRGDQAFTE REASEIMKSI GEAIQYLHSI NIAHRDVKPE NLLYTSKRPN AILKLTDFGF AKETTSHNSL TTPCYTPYYV APEVLGPEKY DKSCDMWSLG VIMYILLCGY PPFYSNHGLA ISPGMKTRIR MGQYEFPNPE WSEVSEEVKM LIRNLLKTEP TQRMTITEFM NHPWIMQSTK VPQTPLHTSR VLKEDKERWE DVKEEMTSAL ATMRVDYEQI KIKKIEDASN PLLLKRRKKA RALEAAALAH // ID 1NXKD STANDARD; PRT; 400 AA. DT CONVERTED FROM PDB (SEQRES) 1NXK DE MAP kinase-activated protein kinase 2 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.700 CC R-Factor 0.239 FT #SUB 186 186 ASP D 229 229 TYR A Protein S 1 FT #SUB 188 188 LYS D 229 229 TYR A Protein S 6 FT #SUB 189 189 PRO D 228 228 TYR A Protein S 2 FT #SUB 190 190 GLU D 228 228 TYR A Protein S 5 FT #SUB 244 244 CYS D 231 231 ALA A Protein S 1 FT #SUB 244 244 CYS D 233 233 GLU A Protein S 1 FT #SUB 247 247 TRP D 229 229 TYR A Protein S 2 FT #SUB 247 247 TRP D 230 230 VAL A Protein S 2 FT #SUB 247 247 TRP D 231 231 ALA A Protein S 9 FT #SUB 247 247 TRP D 232 232 PRO A Protein S 6 FT #SUB 248 248 SER D 229 229 TYR A Protein S 1 FT #SUB 255 255 ILE D 228 228 TYR A Protein S 1 FT #SUB 261 261 PRO D 228 228 TYR A Protein S 1 FT #SUB 267 267 HIS D 44 44 PRO A Protein A 4 FT #SUB 267 267 HIS D 46 46 PHE A Protein B 2 FT #SUB 267 267 HIS D 47 47 HIS A Protein B 2 FT #SUB 268 268 GLY D 46 46 PHE A Protein B 4 FT #SUB 269 269 LEU D 46 46 PHE A Protein B 2 FT #SUB 269 269 LEU D 47 47 HIS A Protein B 5 FT #SUB 270 270 ALA D 47 47 HIS A Protein B 3 FT #SUB 271 271 ILE D 175 175 GLN A Protein S 1 FT #SUB 271 271 ILE D 176 176 TYR A Protein S 1 FT #SUB 272 272 SER D 179 179 SER A Protein S 1 FT #SUB 273 273 PRO D 47 47 HIS A Protein S 4 FT #SUB 277 277 THR D 179 179 SER A Protein S 1 FT #SUB 279 279 ILE D 230 230 VAL A Protein S 3 FT #SUB 279 279 ILE D 232 232 PRO A Protein S 2 FT #SUB 280 280 ARG D 232 232 PRO A Protein B 1 FT #SUB 280 280 ARG D 235 235 LEU A Protein S 4 FT #SUB 281 281 MSE D 175 175 GLN A Protein S 1 FT #SUB 281 281 MSE D 178 178 HIS A Protein S 4 FT #SUB 281 281 MSE D 179 179 SER A Protein S 5 FT #SUB 281 281 MSE D 317 317 THR A Protein B 2 FT #SUB 307 307 LYS D 318 318 GLU A Protein S 1 FT #SUB 308 308 THR D 232 232 PRO A Protein A 3 FT #SUB 309 309 GLU D 240 240 TYR A Protein S 8 FT #SUB 309 309 GLU D 311 311 THR A Protein S 3 FT #SUB 310 310 PRO D 233 233 GLU A Protein S 5 FT #SUB 311 311 THR D 311 311 THR A Protein S 2 FT #SUB 312 312 GLN D 311 311 THR A Protein S 4 FT #SUB 312 312 GLN D 312 312 GLN A Protein S 1 FT #SUB 313 313 ARG D 233 233 GLU A Protein S 5 FT #SUB 72 72 LEU D 357 357 THR C Protein S 3 FT #SUB 128 128 TYR D 267 267 HIS C Protein S 4 FT #SUB 267 267 HIS D 128 128 TYR C Protein S 5 FT #SUB 277 277 THR D 131 131 ARG C Protein S 1 FT #HET 70 70 LEU D 6 401 STU D A 23 FT #HET 71 71 GLY D 6 401 STU D B 7 FT #HET 72 72 LEU D 6 401 STU D B 5 FT #HET 73 73 GLY D 6 401 STU D B 2 FT #HET 78 78 VAL D 6 401 STU D S 12 FT #HET 91 91 ALA D 6 401 STU D S 5 FT #HET 93 93 LYS D 6 401 STU D S 1 FT #HET 138 138 MSE D 6 401 STU D S 5 FT #HET 139 139 GLU D 6 401 STU D B 4 FT #HET 140 140 CYS D 6 401 STU D A 6 FT #HET 141 141 LEU D 6 401 STU D A 9 FT #HET 190 190 GLU D 6 401 STU D B 2 FT #HET 191 191 ASN D 6 401 STU D S 1 FT #HET 193 193 LEU D 6 401 STU D S 2 FT #HET 206 206 THR D 6 401 STU D S 1 FT #HET 207 207 ASP D 6 401 STU D A 5 FT DISORDER 1 42 FT DISORDER 154 157 FT DISORDER 216 223 FT DISORDER 343 400 CC SEQUENCE 288 AA (ATOM); CC FPQFHVKSGL QIKKNAIIDD YKVTSQVLGL GINGKVLQIF NKRTQEKFAL KMLQDCPKAR CC REVELHWRAS QCPHIVRIVD VYENLYAGRK CLLIVMECLD GGELFSRIQD RFTEREASEI CC MKSIGEAIQY LHSINIAHRD VKPENLLYTS KRPNAILKLT DFGFAKETTC YTPYYVAPEV CC LGPEKYDKSC DMWSLGVIMY ILLCGYPPFY SNHGLAISPG MKTRIRMGQY EFPNPEWSEV CC SEEVKMLIRN LLKTEPTQRM TITEFMNHPW IMQSTKVPQT PLHTSRVL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKS CC ATOM ------------------------------------------FPQFHVKS CC ******** CC SEQRES GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK CC ATOM GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK CC ************************************************** CC SEQRES ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI CC ATOM ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI CC ************************************************** CC SEQRES QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN CC ATOM QDR----FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN CC *** ******************************************* CC SEQRES AILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG CC ATOM AILKLTDFGFAKETT--------CYTPYYVAPEVLGPEKYDKSCDMWSLG CC *************** *************************** CC SEQRES VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM CC ATOM VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM CC ************************************************** CC SEQRES LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE CC ATOM LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL-------- CC ****************************************** CC SEQRES DVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH CC ATOM -------------------------------------------------- CC CC SEQRES CC ATOM CC SQ SEQUENCE 400 AA; MW; CN; MLSNSQGQSP PVPFPAPAPP PQPPTPALPH PPAQPPPPPP QQFPQFHVKS GLQIKKNAII DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK ARREVELHWR ASQCPHIVRI VDVYENLYAG RKCLLIVMEC LDGGELFSRI QDRGDQAFTE REASEIMKSI GEAIQYLHSI NIAHRDVKPE NLLYTSKRPN AILKLTDFGF AKETTSHNSL TTPCYTPYYV APEVLGPEKY DKSCDMWSLG VIMYILLCGY PPFYSNHGLA ISPGMKTRIR MGQYEFPNPE WSEVSEEVKM LIRNLLKTEP TQRMTITEFM NHPWIMQSTK VPQTPLHTSR VLKEDKERWE DVKEEMTSAL ATMRVDYEQI KIKKIEDASN PLLLKRRKKA RALEAAALAH //