Brand  (β version)

PDB ID: 1E8X

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Ligands
Code Name Style Show Link
ATP Adenosine-5'-triphosphate PoSSuM
LU Lutetium (III) ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1E8X   PDBj   RCSB PDB   PDBe
Header : PHOSPHOINOSITIDE 3-KINASE GAMMA
Title : STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING
Release Data : 2000-10-26
Compound :
mol_id molecule chains synonym
1 PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT A PTDINS-3-KINASE P110, PI3K
ec: 2.7.1.137
fragment: PI3-KINASE P110 SUBUNIT GAMMA
mutation: YES
other_details: LUTETIUM DERIVATIVE
Source :
mol_id organism_scientific organism_common expression_system
1 SUS SCROFA  (taxid:9823) WILD BOAR SPODOPTERA FRUGIPERDA  (taxid:7108)
cell: NEUTROPHIL
gene: P120S144C
expression_system_strain: Sf9
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PACHLT-C
expression_system_gene: P120S144C
Authors : Walker, E.H., Perisic, O., Ried, C., Stephens, L., Williams, R.L.
Keywords : PHOSPHOINOSITIDE 3-KINASE GAMMA, SECONDARY MESSENGER GENERATION, PI3K, PI 3K
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine

Walker, E.H.,Pacold, M.E.,Perisic, O.  et al.
(2000)  Mol.Cell  6 : 909

PubMed: 11090628
DOI: 10.1016/S1097-2765(05)00089-4

Structural Insights Into Phosphoinositide 3-Kinase Catalysis and Signalling

Walker, E.H.,Perisic, O.,Ried, C.  et al.
(1999)  Nature  402 : 313

PubMed: 10580505
DOI: 10.1038/46319

Reaction

Chain : A
UniProt : O02697 (PK3CG_PIG)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+) 2.7.1.153 UniProtKB:P48736
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) 2.7.1.137 UniProtKB:P48736
left-to-right
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + ADP + H(+) 2.7.1.154 UniProtKB:P48736
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 UniProtKB:P48736
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