ID	1E8XA	STANDARD;	PRT;	961	AA.
DT	CONVERTED FROM PDB (SEQRES) 1E8X
DE	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT
OS	SUS SCROFA
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.200
CC	R-Factor	0.255
FT	#HET	20	 161 	ASP	A	7	3006 	LU	A	S	2
FT	#HET	23	 164 	ASP	A	7	3006 	LU	A	S	3
FT	#HET	663	 804 	MET	A	1	3000 	ATP	A	S	1
FT	#HET	665	 806 	SER	A	1	3000 	ATP	A	S	6
FT	#HET	666	 807 	LYS	A	1	3000 	ATP	A	A	6
FT	#HET	667	 808 	LYS	A	1	3000 	ATP	A	S	1
FT	#HET	669	 810 	PRO	A	1	3000 	ATP	A	S	1
FT	#HET	685	 826 	GLU	A	9	3008 	LU	A	S	1
FT	#HET	690	 831 	ILE	A	1	3000 	ATP	A	S	5
FT	#HET	692	 833 	LYS	A	1	3000 	ATP	A	S	7
FT	#HET	695	 836 	ASP	A	1	3000 	ATP	A	S	1
FT	#HET	695	 836 	ASP	A	6	3005 	LU	A	S	3
FT	#HET	726	 867 	TYR	A	1	3000 	ATP	A	S	6
FT	#HET	738	 879 	ILE	A	1	3000 	ATP	A	S	1
FT	#HET	739	 880 	GLU	A	1	3000 	ATP	A	B	3
FT	#HET	740	 881 	ILE	A	1	3000 	ATP	A	B	2
FT	#HET	741	 882 	VAL	A	1	3000 	ATP	A	A	7
FT	#HET	743	 884 	ASP	A	8	3007 	LU	A	S	3
FT	#HET	743	 884 	ASP	A	10	3009 	LU	A	S	1
FT	#HET	746	 887 	THR	A	1	3000 	ATP	A	S	1
FT	#HET	749	 890 	LYS	A	1	3000 	ATP	A	S	2
FT	#HET	810	 951 	ASN	A	1	3000 	ATP	A	S	3
FT	#HET	810	 951 	ASN	A	2	3001 	LU	A	S	2
FT	#HET	812	 953 	MET	A	1	3000 	ATP	A	S	6
FT	#HET	822	 963 	ILE	A	1	3000 	ATP	A	S	2
FT	#HET	823	 964 	ASP	A	1	3000 	ATP	A	S	19
FT	#HET	823	 964 	ASP	A	2	3001 	LU	A	S	3
FT	#HET	823	 964 	ASP	A	6	3005 	LU	A	S	3
FT	DISORDER	113	124
FT	DISORDER	181	215
FT	DISORDER	295	317
FT	DISORDER	349	355
FT	DISORDER	382	383
FT	DISORDER	389	404
FT	DISORDER	827	841
FT	DISORDER	952	961
CC	SEQUENCE	841 AA (ATOM);
CC	AASEETLAFQ RQLNALIGYD VTDVSNVHDD ELEFTRRRLV TPRMAEVAGR DPKLYAMHPW
CC	VTSKPLPEYL LKKITNNCVF IVIHRSTTSQ TIKVSADDTP GTILQSFFTK MANERDFVLR
CC	VCGRDEYLVG ETPIKNFQWV RQCLKNGEEI HLVLDTPPDP ALDEVRKECD RKFRVKIRGI
CC	DIPVLPRTAD LTVFVEANIQ YGQQVLCQRR TSPKPFTEEV LWNVWLEFSI KIKDLPKGAL
CC	LNLQIYCQLL YYVNLLLIDH RFLLRHGEYV LHMWQLSGFN ADKLTSATNP DKENSMSISI
CC	LLDNHPIALE MPNQLRKQLE AIIATDPLNP LTAEDKELLW HFRYESLKDP KAYPKLFSSV
CC	KWGQQEIVAK TYQLLAKREV WDQSALDVGL TMQLLDCNFS DENVRAIAVQ KLESLEDDDV
CC	LHYLLQLVQA VKFEPYHDSA LARFLLKRGL RNKRIGHFLF WFLRSEIAQS RHYQQRFAVI
CC	LEAYLRGCGT AMLHDFTQQV QVIDMLQKVT IDIKSLSAEK YDVSSQVISQ LKQKLENLQN
CC	LNLPQSFRVP YDPGLKAGAL VIEKCKVMAS KKKPLWLEFK CADPTALSNE TIGIIFKHGD
CC	DLRQDMLILQ ILRIMESIWE TESLDLCLLP YGCISTGDKI GMIEIVKDAT TIAKIQQSTV
CC	GNTGAFKDEV LSHWLKEKCP IEEKFQAAVE RFVYSCAGYC VATFVLGIGD RHNDNIMISE
CC	TGNLFHIDFG HVPFVLTPDF LFVMGTSGKK TSLHFQKFQD VCVKAYLALR HHTNLLIILF
CC	SMMLMTGMPQ LTSKEDIEYI RDALTVGKSE EDAKKYFLDQ IEVCRDKGWT VQFNWFLHLV
CC	L
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES AASEETLAFQRQLNALIGYDVTDVSNVHDDELEFTRRRLVTPRMAEVAGR
CC	ATOM   AASEETLAFQRQLNALIGYDVTDVSNVHDDELEFTRRRLVTPRMAEVAGR
CC	       **************************************************
CC	SEQRES DPKLYAMHPWVTSKPLPEYLLKKITNNCVFIVIHRSTTSQTIKVSADDTP
CC	ATOM   DPKLYAMHPWVTSKPLPEYLLKKITNNCVFIVIHRSTTSQTIKVSADDTP
CC	       **************************************************
CC	SEQRES GTILQSFFTKMAKKKSLMDIPESQNERDFVLRVCGRDEYLVGETPIKNFQ
CC	ATOM   GTILQSFFTKMA------------NERDFVLRVCGRDEYLVGETPIKNFQ
CC	       ************            **************************
CC	SEQRES WVRQCLKNGEEIHLVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTI
CC	ATOM   WVRQCLKNGEEIHLVLDTPPDPALDEVRKE--------------------
CC	       ******************************                    
CC	SEQRES HGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRTADLTVFVEANIQYGQ
CC	ATOM   ---------------CDRKFRVKIRGIDIPVLPRTADLTVFVEANIQYGQ
CC	                      ***********************************
CC	SEQRES QVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPAL
CC	ATOM   QVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYC------
CC	       ********************************************      
CC	SEQRES SGKTSAEMPSPESKGKAQLLYYVNLLLIDHRFLLRHGEYVLHMWQLSGKG
CC	ATOM   -----------------QLLYYVNLLLIDHRFLLRHGEYVLHMWQLSG--
CC	                        *******************************  
CC	SEQRES EDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHRPTPDPEGD
CC	ATOM   -----FNADKLTSATNPDKENSMSISILLDN--HPIAL------------
CC	            **************************  *****            
CC	SEQRES RVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKDPKAYPK
CC	ATOM   ----EMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKDPKAYPK
CC	           **********************************************
CC	SEQRES LFSSVKWGQQEIVAKTYQLLAKREVWDQSALDVGLTMQLLDCNFSDENVR
CC	ATOM   LFSSVKWGQQEIVAKTYQLLAKREVWDQSALDVGLTMQLLDCNFSDENVR
CC	       **************************************************
CC	SEQRES AIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRI
CC	ATOM   AIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRI
CC	       **************************************************
CC	SEQRES GHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIDM
CC	ATOM   GHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIDM
CC	       **************************************************
CC	SEQRES LQKVTIDIKSLSAEKYDVSSQVISQLKQKLENLQNLNLPQSFRVPYDPGL
CC	ATOM   LQKVTIDIKSLSAEKYDVSSQVISQLKQKLENLQNLNLPQSFRVPYDPGL
CC	       **************************************************
CC	SEQRES KAGALVIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQD
CC	ATOM   KAGALVIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQD
CC	       **************************************************
CC	SEQRES MLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKI
CC	ATOM   MLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKI
CC	       **************************************************
CC	SEQRES QQSTVGNTGAFKDEVLSHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFV
CC	ATOM   QQSTVGNTGAFKDEVLSHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFV
CC	       **************************************************
CC	SEQRES LGIGDRHNDNIMISETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDF
CC	ATOM   LGIGDRHNDNIMISETGNLFHIDFGH---------------VPFVLTPDF
CC	       **************************               *********
CC	SEQRES LFVMGTSGKKTSLHFQKFQDVCVKAYLALRHHTNLLIILFSMMLMTGMPQ
CC	ATOM   LFVMGTSGKKTSLHFQKFQDVCVKAYLALRHHTNLLIILFSMMLMTGMPQ
CC	       **************************************************
CC	SEQRES LTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLV
CC	ATOM   LTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLV
CC	       **************************************************
CC	SEQRES LGIKQGEKHSA
CC	ATOM   L----------
CC	       *          
SQ	SEQUENCE	961 AA;      MW;         CN;
	AASEETLAFQ RQLNALIGYD VTDVSNVHDD ELEFTRRRLV TPRMAEVAGR DPKLYAMHPW
	VTSKPLPEYL LKKITNNCVF IVIHRSTTSQ TIKVSADDTP GTILQSFFTK MAKKKSLMDI
	PESQNERDFV LRVCGRDEYL VGETPIKNFQ WVRQCLKNGE EIHLVLDTPP DPALDEVRKE
	EWPLVDDCTG VTGYHEQLTI HGKDHESVFT VSLWDCDRKF RVKIRGIDIP VLPRTADLTV
	FVEANIQYGQ QVLCQRRTSP KPFTEEVLWN VWLEFSIKIK DLPKGALLNL QIYCGKAPAL
	SGKTSAEMPS PESKGKAQLL YYVNLLLIDH RFLLRHGEYV LHMWQLSGKG EDQGSFNADK
	LTSATNPDKE NSMSISILLD NYCHPIALPK HRPTPDPEGD RVRAEMPNQL RKQLEAIIAT
	DPLNPLTAED KELLWHFRYE SLKDPKAYPK LFSSVKWGQQ EIVAKTYQLL AKREVWDQSA
	LDVGLTMQLL DCNFSDENVR AIAVQKLESL EDDDVLHYLL QLVQAVKFEP YHDSALARFL
	LKRGLRNKRI GHFLFWFLRS EIAQSRHYQQ RFAVILEAYL RGCGTAMLHD FTQQVQVIDM
	LQKVTIDIKS LSAEKYDVSS QVISQLKQKL ENLQNLNLPQ SFRVPYDPGL KAGALVIEKC
	KVMASKKKPL WLEFKCADPT ALSNETIGII FKHGDDLRQD MLILQILRIM ESIWETESLD
	LCLLPYGCIS TGDKIGMIEI VKDATTIAKI QQSTVGNTGA FKDEVLSHWL KEKCPIEEKF
	QAAVERFVYS CAGYCVATFV LGIGDRHNDN IMISETGNLF HIDFGHILGN YKSFLGINKE
	RVPFVLTPDF LFVMGTSGKK TSLHFQKFQD VCVKAYLALR HHTNLLIILF SMMLMTGMPQ
	LTSKEDIEYI RDALTVGKSE EDAKKYFLDQ IEVCRDKGWT VQFNWFLHLV LGIKQGEKHS
	A
//