PDB ID: 1DHJ
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Structure summary
Code : | 1DHJ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE | ||||||||||||
Release Data : | 1994-01-31 | ||||||||||||
Compound : |
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Source : |
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Authors : | Brown, K.A., Kraut, J. | ||||||||||||
Keywords : | OXIDOREDUCTASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.8 Å ) | ||||||||||||
Citation : |
Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase.
Brown, K.A.,Howell, E.E.,Kraut, J.
PubMed: 8265622 How Do Mutation at Phenylalanine-153 and Isoleucine-155 Partially Suppress the Effects of the Aspartate-27-> Serine Mutation in Escherichia Coli Dihydrofolate Reductase
Dion, A.,Linn, C.E.,Bradrick, T.D.
et al.
Role of Aspartate 27 of Dihydrofolate Reductase from Escherichia Coli in Interconversion of Active and Inactive Enzyme Conformers and the Binding of Nadph
Appleman, J.R.,Howell, E.E.,Kraut, J.
et al.
A Second-Site Mutation at Phenylalanine-137 that Increases Catalytic Efficiency in the Mutant Aspartate-27-> Serine Escherichia Coli Dihydrofolate Reductase
Howell, E.E.,Booth, C.,Farnum, M.
et al.
Dihydrofolate Reductase from Escherichia Coli: Probing the Role of Aspartate-27 and Phenylalanine-137 in Enzyme Conformation and the Binding of Nadph
Dunn, S.M.,Lanigan, T.M.,Howell, E.E.
Functional Role of Aspartic Acid-27 in Dihydrofolate Reductase Revealed by Mutagenesis
Howell, E.E.,Villafranca, J.E.,Waren, M.S.
et al.
Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase at 1.7 Angstroms Resolution. I. General Features and Binding of Methotrexate
Bolin, J.T.,Filman, D.J.,Matthews, D.A.
et al.
Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase at 1.7 Angstroms Resolution. II. Environment of Bound Nadph and Implications for Catalysis
Filman, D.J.,Bolin, J.T.,Matthews, D.A.
et al.
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Reaction
Chain : | A, B | ||||||||
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UniProt : | P0ABQ4 (DYR_ECOLI) | ||||||||
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