Brand  (β version)

PDB ID: 1DF7

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
MTX Methotrexate PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
SO4 Sulfate ion PoSSuM
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Structure summary

Code : 1DF7   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE
Release Data : 2000-03-09
Compound :
mol_id molecule chains synonym
1 DIHYDROFOLATE REDUCTASE A DHFR
ec: 1.5.1.3
Source :
mol_id organism_scientific
1 Mycobacterium tuberculosis  (taxid:1773)
Authors : Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.
Keywords : DIHYDROFOLATE REDUCTASE, STRUCTURE-BASED INHIBITOR DESIGN, FOLATEANALOGS, ROSSMANN FOLD, NICOTINAMIDE ADENINE DINUCLEOTIDE, METHOTREXATE, TUBERCULOSIS, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.7 Å )
Citation :

Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.

Li, R.,Sirawaraporn, R.,Chitnumsub, P.  et al.
(2000)  J.Mol.Biol.  295 : 307 - 323

PubMed: 10623528
DOI: 10.1006/jmbi.1999.3328

Comparison of Two Independent Crystal Structures of Human Dihydrofolate Reductase Ternary Complexes Reduced with Nicotinamide Adenine Dinucleotide Phosphate and the Very Tight-Binding Inhibitor PT523

Cody, V.,Galitsky, N.,Luft, J.R.  et al.
(1997)  Biochemistry  36 : 13897 - 13903

DOI: 10.1021/bi971711l

Reaction

Chain : A
UniProt : P0A546 (multiple entry names are found)
Reaction : -