Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
PT Platinum (II) ion
SM Samarium (III) ion
Code : 1BIX
Header : DNA REPAIR
Title : THE CRYSTAL STRUCTURE OF THE HUMAN DNA REPAIR ENDONUCLEASE HAP1 SUGGESTS THE RECOGNITION OF EXTRA-HELICAL DEOXYRIBOSE AT DNA ABASIC SITES
Release Data : 1999-06-22
Compound :
mol_id molecule chains
1 AP ENDONUCLEASE 1 A
ec: 4.2.99.18
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21 (DE3)
Authors : Gorman, M.A., Morera, S., Rothwell, D.G., De La Fortelle, E., Mol, C.D., Tainer, J.A., Hickson, I.D., Freemont, P.S.
Keywords : DNA REPAIR, ENDONUCLEASE, HAP1, REF-1, ABASIC SITE RECOGNITION
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.

Gorman, M.A.,Morera, S.,Rothwell, D.G.  et al.
(1997)  EMBO J.  16 : 6548 - 6558

PubMed: 9351835
DOI: 10.1093/emboj/16.21.6548

Crystal Structure of the Human DNA Repair Enzyme Ap Endonuclease 1

Gorman, M.A.
(1998)  Thesis, The Open University 

Chain : A
UniProt : P27695 (APEX1_HUMAN)
Reaction : The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.