Het-PDB Navi2 (PDB: 1AXS)

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Ligands
Code	Name		Style	Show	Link
CD	Cadmium ion				PoSSuM
HOP	(1s,2s,5s)2-(4-glutaridylbenzyl)-5-phenyl-1-cyclohexanol				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1AXS

Code :

1AXS PDBj RCSB PDB PDBe

Header :

CATALYTIC ANTIBODY

Title :

MATURE OXY-COPE CATALYTIC ANTIBODY WITH HAPTEN

Release Data :

1998-02-04

Compound :

mol_id	molecule	chains
1	OXY-COPE CATALYTIC ANTIBODY	L,A
	fragment: FAB FRAGMENT other_details: CHIMERIC FAB FRAGMENT

mol_id	molecule	chains
2	OXY-COPE CATALYTIC ANTIBODY	H,B
	fragment: FAB FRAGMENT other_details: CHIMERIC FAB FRAGMENT

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	fragment: CHAIN L, A, 108 - 211, CHAIN H, B, 114 - 214 strain: SWISS WEBSTER cell_line: AZ-28 HYBRIDOMA organ: SPLEEN cell: B LYMPHOCYTE expression_system_strain: 25F2 expression_system_cellular_location: PERIPLASM expression_system_vector_type: PLASMID expression_system_vector: PAZ-28 expression_system_plasmid: PAZ-28 other_details: THE PROTEIN WAS PRODUCED AS CHIMERIC FAB FRAGMENT. THE CONSTANT DOMAINS ARE HUMAN, THE VARIABLE DOMAINS ARE MURINE. PRODUCTION BY EXPRESSION FROM PHOA PROMOTER

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	fragment: CHAIN L, A, 108 - 211, CHAIN H, B, 114 - 214 strain: SWISS WEBSTER cell_line: AZ-28 HYBRIDOMA organ: SPLEEN cell: B LYMPHOCYTE expression_system_strain: 25F2 expression_system_cellular_location: PERIPLASM expression_system_vector_type: PLASMID expression_system_vector: PAZ-28 expression_system_plasmid: PAZ-28 other_details: THE PROTEIN WAS PRODUCED AS CHIMERIC FAB FRAGMENT. THE CONSTANT DOMAINS ARE HUMAN, THE VARIABLE DOMAINS ARE MURINE. PRODUCTION BY EXPRESSION FROM PHOA PROMOTER

Authors :

Mundorff, E.C., Ulrich, H.D., Stevens, R.C.

Keywords :

OXY-COPE, CATALYTIC ANTIBODY, FAB FRAGMENT

Exp. method :

X-RAY DIFFRACTION ( 2.6 Å )

Citation :

The interplay between binding energy and catalysis in the evolution of a catalytic antibody.

Ulrich, H.D.,Mundorff, E.,Santarsiero, B.D. et al.
(1997) Nature 389 : 271 - 275

PDB ID: 1AXS