Het-PDB Navi2 (PDB: 1AO8)

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Ligands
Code	Name		Style	Show	Link
MTX	Methotrexate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1AO8

Code :

1AO8 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE, NMR, 21 STRUCTURES

Release Data :

1998-02-25

Compound :

mol_id	molecule	chains	synonym
1	DIHYDROFOLATE REDUCTASE	A	DHFR
	ec: 1.5.1.3

Source :

mol_id	organism_scientific	expression_system
1	Lactobacillus casei (taxid:1582)	Escherichia coli (taxid:562)
	strain: METHOTREXATE-RESISTANT expression_system_strain: NF1 expression_system_plasmid: PMT702

Authors :

Gargaro, A.R., Soteriou, A., Frenkiel, T.A., Bauer, C.J., Birdsall, B., Polshakov, V.I., Barsukov, I.L., Roberts, G.C.K., Feeney, J.

Keywords :

OXIDOREDUCTASE, INHIBITOR-ENZYME COMPLEX

Exp. method :

SOLUTION NMR

Citation :

The solution structure of the complex of Lactobacillus casei dihydrofolate reductase with methotrexate.

Gargaro, A.R.,Soteriou, A.,Frenkiel, T.A. et al.
(1998) J.Mol.Biol. 277 : 119 - 134

PubMed: 9514736
DOI: 10.1006/jmbi.1997.1560

Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase Refined at 1.7 A Resolution. I. General Features and Binding of Methotrexate

Bolin, J.T.,Filman, D.J.,Matthews, D.A. et al.
(1982) J.Biol.Chem. 257 : 13650

Chain :

UniProt :

P00381 (DYR_LACCA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH	1.5.1.3	PROSITE- ProRule:PRU00660
	-	PROSITE- ProRule:PRU00660

PDB ID: 1AO8

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