Het-PDB Navi2 (PDB: 6ZS3)

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Ligands
Code	Name		Style	Show	Link
FX5	2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol				PoSSuM
EDO	1,2-ethanediol				PoSSuM

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Download interaction data: 6ZS3

Code :

6ZS3 PDBj RCSB PDB PDBe

Header :

GENE REGULATION

Title :

Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol

Release Data :

2020-10-07

Compound :

mol_id	molecule	chains	synonym
1	Protein polybromo-1	A,B	hPB1,BRG1-associated factor 180,BAF180,Polybromo-1D

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PBRM1, BAF180, PB1

Authors :

Preuss, F., Joerger, A.C., Wanior, M., Kraemer, A., Knapp, S., Structural Genomics Consortium (SGC)

Keywords :

BROMODOMAIN, COMPLEX, SMALL MOLECULE, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSCRIPTION, GENE REGULATION

Exp. method :

X-RAY DIFFRACTION ( 1.67 Å )

Citation :

Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.

Wanior, M.,Preuss, F.,Ni, X. et al.
(2020) J.Med.Chem. 63 : 14680 - 14699

PDB ID: 6ZS3