Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
08T [[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-tris(fluoranyl)beryllium
ADP Adenosine-5'-diphosphate
MG Magnesium ion
ZN Zinc ion
Code : 6MII   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/DNA
Title : Crystal structure of minichromosome maintenance protein MCM/DNA complex
Release Data : 2019-07-24
Compound :
mol_id molecule chains
1 Minichromosome maintenance protein MCM A,B,C,D,E,F
ec: 3.6.4.12
mutation: UNP residues 2-265, GGSGGS linker, UNP residues 275-612
mol_id molecule chains
2 DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3') X
Source :
mol_id organism_scientific expression_system
1 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)  (taxid:273057) Escherichia coli BL21(DE3)  (taxid:469008)
strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2
gene: MCM, SSO0774
expression_system_strain: BL21(DE3)-RIPL
expression_system_vector_type: plasmid
expression_system_plasmid: pEE078.1
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Enemark, E.J., Meagher, M., Epling, L.B.
Keywords : MCM, DNA, helicase, AAA+, HYDROLASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 3.15 Å )
Citation :

DNA translocation mechanism of the MCM complex and implications for replication initiation.

Meagher, M.,Epling, L.B.,Enemark, E.J.
(2019)  Nat Commun  10 : 3117 - 3117

PubMed: 31308367
DOI: 10.1038/s41467-019-11074-3

Chain : A, B, C, D, E, F
UniProt : Q9UXG1 (MCM_SACS2)
Reaction : Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000269|PubMed:17964268, ECO:0000269|PubMed:19073923};