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Ligands
Code Name Style Show Link
MET Methionine
Non-standard Residues
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Glycosylation
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Code : 6CML   PDBj   RCSB PDB   PDBe
Header : ligase/ligase inhibitor
Title : Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 2093)
Release Data : 2019-03-13
Compound :
mol_id molecule chains
1 Methionyl-tRNA synthetase A,B
ec: 6.1.1.10
mutation: A309T, K452T, K453A, E454A, A499V, S503N
Source :
mol_id organism_scientific expression_system
1 Trypanosoma brucei brucei  (taxid:185431) Escherichia coli  (taxid:562)
strain: 927/4 GUTat10.1
gene: Tb10.70.6470
Authors : Barros-Alvarez, X., Hol, W.G.J.
Keywords : synthetase, ligase, methionine, inhibitor, Ligase-Ligase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei

Zhang, Z.,Barros-Alvarez, X.,Gillespie, J.R.  et al.
(2020)  Rsc Med Chem  11 : 885 - 895

DOI: 10.1039/D0MD00057D

Chain : A, B
UniProt : Q38C91 (Q38C91_TRYB2)
Reaction : -