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Ligands
Code Name Style Show Link
AKR Acrylic acid
MA4 Cyclohexyl-hexyl-beta-D-maltoside
TAZ Tazobactam
TBE Tazobactam intermediate
Non-standard Residues
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Glycosylation
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Code : 1VM1   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM
Release Data : 2004-09-07
Compound :
mol_id molecule chains
1 BETA-LACTAMASE SHV-1 A
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli str. K-12 substr. DH10B  (taxid:316385)
gene: BLA
expression_system_strain: DH10B
expression_system_vector_type: PLASMID
expression_system_plasmid: PBCSK
Authors : Kuzin, A.P., Nukaga, M., Nukaga, Y., Hujer, A., Bonomo, R.A., Knox, J.R.
Keywords : Beta-LACTAMASE, BETA-LACTAM HYDROLASE, PENICILLINASE, DETERGENT Binding, Inhibitor design, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.02 Å )
Citation :

Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam.

Kuzin, A.P.,Nukaga, M.,Nukaga, Y.  et al.
(2001)  Biochemistry  40 : 1861 - 1866

PubMed: 11327849
DOI: 10.1021/bi0022745

Structure of the SHV-1 Beta-Lactamase

Kuzin, A.P.,Nukaga, M.,Nukaga, Y.  et al.
(1999)  Biochemistry  38 : 5720 - 5727

Chain : A
UniProt : Q9F643 (Q9F643_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 ARBA:ARBA00001526, RuleBase:RU361140
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