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Ligands
Code Name Style Show Link
0Z6 D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide
CA Calcium ion
CAC Cacodylate ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BGC Beta-D-glucopyranose
GAL Beta-D-galactopyranose
FUC Alpha-L-fucopyranose
Modification
Code Name Show
ACE Acetyl group
Code : 1DVA   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal Structure of the Complex Between the Peptide Exosite Inhibitor E-76 and Coagulation Factor VIIA
Release Data : 2000-05-12
Compound :
mol_id molecule chains
1 DES-GLA FACTOR VIIA (HEAVY CHAIN) H,I
ec: 3.4.21.21
mol_id molecule chains
2 DES-GLA FACTOR VIIA (LIGHT CHAIN) L,M
ec: 3.4.21.21
mol_id molecule chains
3 PEPTIDE E-76 X,Y
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
organ: LIVER
expression_system_common: Human
expression_system_cell_line: HUMAN KIDNEY CELL LINE 293
expression_system_plasmid: PCMV5
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
organ: LIVER
expression_system_common: Human
expression_system_cell_line: HUMAN KIDNEY CELL LINE 293
expression_system_plasmid: PCMV5
mol_id organism_scientific
3
synthetic: yes
other_details: Peptide E-76 was synthesized on a solid support, then cleaved and purified
Authors : Eigenbrot, C., Ultsch, M.H.
Keywords : protein-peptide complex, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Peptide exosite inhibitors of factor VIIa as anticoagulants.

Dennis, M.S.,Eigenbrot, C.,Skelton, N.J.  et al.
(2000)  Nature  404 : 465 - 470

PubMed: 10761907
DOI: 10.1038/35006574

Chain : L, M
UniProt : P08709 (FA7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. 3.4.21.21 -
-