ID 4LM3A STANDARD; PRT; 345 AA. DT CONVERTED FROM PDB (SEQRES) 4LM3 DE cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.490 CC R-Factor 0.200 FT #SUB 23 467 ARG A 313 757 ASP B Protein S 1 FT #SUB 23 467 ARG A 316 760 SER B Protein S 2 FT #SUB 32 476 HIS A 323 767 ARG B Protein S 9 FT #SUB 34 478 ASP A 287 731 ASN B Protein S 1 FT #SUB 37 481 PRO A 287 731 ASN B Protein S 2 FT #SUB 37 481 PRO A 291 735 ILE B Protein B 1 FT #SUB 37 481 PRO A 312 756 ARG B Protein B 4 FT #SUB 37 481 PRO A 315 759 LEU B Protein S 2 FT #SUB 38 482 PHE A 312 756 ARG B Protein A 3 FT #SUB 40 484 ASN A 312 756 ARG B Protein S 1 FT #SUB 41 485 MET A 312 756 ARG B Protein S 1 FT #SUB 237 681 LEU A 283 727 LEU B Protein S 1 FT #SUB 238 682 TRP A 280 724 GLN B Protein S 2 FT #SUB 239 683 PRO A 280 724 GLN B Protein S 5 FT #SUB 239 683 PRO A 284 728 GLY B Protein S 2 FT #SUB 243 687 LEU A 287 731 ASN B Protein S 1 FT #SUB 243 687 LEU A 288 732 ALA B Protein S 1 FT #SUB 317 761 GLN A 277 721 GLU B Protein S 3 FT #SUB 317 761 GLN A 280 724 GLN B Protein S 1 FT #SUB 320 764 LYS A 277 721 GLU B Protein S 4 FT #SUB 324 768 GLY A 268 712 PRO B Protein B 2 FT #SUB 325 769 GLU A 268 712 PRO B Protein B 1 FT #SUB 326 770 GLU A 268 712 PRO B Protein B 1 FT #SUB 326 770 GLU A 269 713 MET B Protein B 3 FT #SUB 327 771 THR A 269 713 MET B Protein B 4 FT #SUB 327 771 THR A 277 721 GLU B Protein A 7 FT #SUB 328 772 ALA A 249 693 TYR B Protein S 2 FT #SUB 328 772 ALA A 252 696 PHE B Protein S 2 FT #SUB 328 772 ALA A 269 713 MET B Protein B 1 FT #SUB 330 774 TRP A 248 692 ILE B Protein S 7 FT #SUB 330 774 TRP A 249 693 TYR B Protein S 1 FT #SUB 330 774 TRP A 252 696 PHE B Protein S 1 FT #SUB 330 774 TRP A 281 725 GLY B Protein S 4 FT #SUB 330 774 TRP A 285 729 PHE B Protein S 3 FT #SUB 330 774 TRP A 288 732 ALA B Protein B 2 FT #SUB 331 775 ILE A 195 639 PHE B Protein B 2 FT #SUB 331 775 ILE A 288 732 ALA B Protein B 3 FT #SUB 332 776 SER A 195 639 PHE B Protein B 1 FT #SUB 332 776 SER A 288 732 ALA B Protein A 3 FT #HET 80 524 TYR A 1 801 9ZE A S 1 FT #HET 85 529 HIS A 2 802 NI A S 3 FT #HET 119 563 HIS A 2 802 NI A S 3 FT #HET 120 564 ASP A 2 802 NI A S 3 FT #HET 120 564 ASP A 3 803 NI A S 3 FT #HET 230 674 ASP A 2 802 NI A S 3 FT #HET 233 677 SER A 1 801 9ZE A S 4 FT #HET 242 686 LYS A 5 805 EDO A S 3 FT #HET 245 689 ALA A 1 801 9ZE A B 1 FT #HET 245 689 ALA A 5 805 EDO A A 4 FT #HET 246 690 ASN A 5 805 EDO A A 7 FT #HET 248 692 ILE A 1 801 9ZE A S 3 FT #HET 249 693 TYR A 5 805 EDO A S 1 FT #HET 252 696 PHE A 1 801 9ZE A S 1 FT #HET 253 697 TRP A 5 805 EDO A S 1 FT #HET 269 713 MET A 1 801 9ZE A S 2 FT #HET 272 716 ARG A 4 804 EDO A B 1 FT #HET 273 717 ASP A 4 804 EDO A B 5 FT #HET 274 718 LYS A 4 804 EDO A B 5 FT #HET 275 719 LYS A 4 804 EDO A A 10 FT #HET 276 720 ASP A 4 804 EDO A A 12 FT #HET 278 722 VAL A 5 805 EDO A S 2 FT #HET 282 726 GLN A 1 801 9ZE A S 4 FT #HET 285 729 PHE A 1 801 9ZE A S 10 FT #HET 318 762 TRP A 5 805 EDO A S 1 FT DISORDER 1 1 FT DISORDER 333 345 CC SEQUENCE 331 AA (ATOM); CC AGTSICTSEE WQGLMQFTLP VRLCKEIELF HFDIGPFENM WPGIFVYMVH RSCGTSCFEL CC EKLCRFIMSV KKNYRRVPYH NWKHAVTVAH CMYAILQNNH TLFTDLERKG LLIACLCHDL CC DHRGFSNSYL QKFDHPLAAL YSTSTMEQHH FSQTVSILQL EGHNIFSTLS SSEYEQVLEI CC IRKAIIATDL ALYFGNRKQL EEMYQTGSLN LNNQSHRDRV IGLMMTACDL CSVTKLWPVT CC KLTANDIYAE FWAEGDEMKK LGIQPIPMMD RDKKDEVPQG QLGFYNAVAI PCYTTLTQIL CC PPTEPLLKAC RDNLSQWEKV IRGEETATWI S CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GAGTSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMV CC ATOM -AGTSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMV CC ************************************************* CC SEQRES HRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNN CC ATOM HRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNN CC ************************************************** CC SEQRES HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQH CC ATOM HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQH CC ************************************************** CC SEQRES HFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQ CC ATOM HFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQ CC ************************************************** CC SEQRES LEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA CC ATOM LEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA CC ************************************************** CC SEQRES EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI CC ATOM EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI CC ************************************************** CC SEQRES LPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED CC ATOM LPPTEPLLKACRDNLSQWEKVIRGEETATWIS------------- CC ******************************** SQ SEQUENCE 345 AA; MW; CN; GAGTSICTSE EWQGLMQFTL PVRLCKEIEL FHFDIGPFEN MWPGIFVYMV HRSCGTSCFE LEKLCRFIMS VKKNYRRVPY HNWKHAVTVA HCMYAILQNN HTLFTDLERK GLLIACLCHD LDHRGFSNSY LQKFDHPLAA LYSTSTMEQH HFSQTVSILQ LEGHNIFSTL SSSEYEQVLE IIRKAIIATD LALYFGNRKQ LEEMYQTGSL NLNNQSHRDR VIGLMMTACD LCSVTKLWPV TKLTANDIYA EFWAEGDEMK KLGIQPIPMM DRDKKDEVPQ GQLGFYNAVA IPCYTTLTQI LPPTEPLLKA CRDNLSQWEK VIRGEETATW ISSPSVAQKA AASED // ID 4LM3B STANDARD; PRT; 345 AA. DT CONVERTED FROM PDB (SEQRES) 4LM3 DE cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.490 CC R-Factor 0.200 FT #SUB 195 639 PHE B 331 775 ILE A Protein S 2 FT #SUB 195 639 PHE B 332 776 SER A Protein S 1 FT #SUB 248 692 ILE B 330 774 TRP A Protein A 7 FT #SUB 249 693 TYR B 328 772 ALA A Protein S 2 FT #SUB 249 693 TYR B 330 774 TRP A Protein S 1 FT #SUB 252 696 PHE B 328 772 ALA A Protein S 2 FT #SUB 252 696 PHE B 330 774 TRP A Protein S 1 FT #SUB 268 712 PRO B 324 768 GLY A Protein S 2 FT #SUB 268 712 PRO B 325 769 GLU A Protein S 1 FT #SUB 268 712 PRO B 326 770 GLU A Protein S 1 FT #SUB 269 713 MET B 326 770 GLU A Protein A 3 FT #SUB 269 713 MET B 327 771 THR A Protein A 4 FT #SUB 269 713 MET B 328 772 ALA A Protein S 1 FT #SUB 277 721 GLU B 317 761 GLN A Protein S 3 FT #SUB 277 721 GLU B 320 764 LYS A Protein S 4 FT #SUB 277 721 GLU B 327 771 THR A Protein S 7 FT #SUB 280 724 GLN B 238 682 TRP A Protein S 2 FT #SUB 280 724 GLN B 239 683 PRO A Protein A 5 FT #SUB 280 724 GLN B 317 761 GLN A Protein S 1 FT #SUB 281 725 GLY B 330 774 TRP A Protein B 4 FT #SUB 283 727 LEU B 237 681 LEU A Protein S 1 FT #SUB 284 728 GLY B 239 683 PRO A Protein B 2 FT #SUB 285 729 PHE B 330 774 TRP A Protein S 3 FT #SUB 287 731 ASN B 34 478 ASP A Protein S 1 FT #SUB 287 731 ASN B 37 481 PRO A Protein S 2 FT #SUB 287 731 ASN B 243 687 LEU A Protein S 1 FT #SUB 288 732 ALA B 243 687 LEU A Protein S 1 FT #SUB 288 732 ALA B 330 774 TRP A Protein S 2 FT #SUB 288 732 ALA B 331 775 ILE A Protein S 3 FT #SUB 288 732 ALA B 332 776 SER A Protein A 3 FT #SUB 291 735 ILE B 37 481 PRO A Protein S 1 FT #SUB 312 756 ARG B 37 481 PRO A Protein S 4 FT #SUB 312 756 ARG B 38 482 PHE A Protein S 3 FT #SUB 312 756 ARG B 40 484 ASN A Protein S 1 FT #SUB 312 756 ARG B 41 485 MET A Protein S 1 FT #SUB 313 757 ASP B 23 467 ARG A Protein S 1 FT #SUB 315 759 LEU B 37 481 PRO A Protein S 2 FT #SUB 316 760 SER B 23 467 ARG A Protein S 2 FT #SUB 323 767 ARG B 32 476 HIS A Protein S 9 FT #HET 85 529 HIS B 7 802 NI B S 3 FT #HET 119 563 HIS B 7 802 NI B S 3 FT #HET 120 564 ASP B 7 802 NI B S 3 FT #HET 120 564 ASP B 8 803 NI B S 3 FT #HET 230 674 ASP B 7 802 NI B S 3 FT #HET 265 709 GLN B 6 801 EDO B A 4 FT #HET 266 710 PRO B 6 801 EDO B B 2 FT DISORDER 1 3 FT DISORDER 331 345 CC SEQUENCE 327 AA (ATOM); CC TSICTSEEWQ GLMQFTLPVR LCKEIELFHF DIGPFENMWP GIFVYMVHRS CGTSCFELEK CC LCRFIMSVKK NYRRVPYHNW KHAVTVAHCM YAILQNNHTL FTDLERKGLL IACLCHDLDH CC RGFSNSYLQK FDHPLAALYS TSTMEQHHFS QTVSILQLEG HNIFSTLSSS EYEQVLEIIR CC KAIIATDLAL YFGNRKQLEE MYQTGSLNLN NQSHRDRVIG LMMTACDLCS VTKLWPVTKL CC TANDIYAEFW AEGDEMKKLG IQPIPMMDRD KKDEVPQGQL GFYNAVAIPC YTTLTQILPP CC TEPLLKACRD NLSQWEKVIR GEETATW CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GAGTSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMV CC ATOM ---TSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMV CC *********************************************** CC SEQRES HRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNN CC ATOM HRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNN CC ************************************************** CC SEQRES HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQH CC ATOM HTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQH CC ************************************************** CC SEQRES HFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQ CC ATOM HFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQ CC ************************************************** CC SEQRES LEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA CC ATOM LEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA CC ************************************************** CC SEQRES EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI CC ATOM EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI CC ************************************************** CC SEQRES LPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED CC ATOM LPPTEPLLKACRDNLSQWEKVIRGEETATW--------------- CC ****************************** SQ SEQUENCE 345 AA; MW; CN; GAGTSICTSE EWQGLMQFTL PVRLCKEIEL FHFDIGPFEN MWPGIFVYMV HRSCGTSCFE LEKLCRFIMS VKKNYRRVPY HNWKHAVTVA HCMYAILQNN HTLFTDLERK GLLIACLCHD LDHRGFSNSY LQKFDHPLAA LYSTSTMEQH HFSQTVSILQ LEGHNIFSTL SSSEYEQVLE IIRKAIIATD LALYFGNRKQ LEEMYQTGSL NLNNQSHRDR VIGLMMTACD LCSVTKLWPV TKLTANDIYA EFWAEGDEMK KLGIQPIPMM DRDKKDEVPQ GQLGFYNAVA IPCYTTLTQI LPPTEPLLKA CRDNLSQWEK VIRGEETATW ISSPSVAQKA AASED //