1	M1R	1-{4-[2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4-yl]piperazin-1-yl}propan-1-one	1.000
2	QH4	{(2s)-4-[2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4-yl]-1-propanoylpiperazin-2-yl}acetonitrile	0.927
3	A1B7W	Adagrasib	0.884
4	A1B8E	[(2s)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile	0.884
5	M1X	{(2s)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4-yl]-1-[(2s)-2-fluoropropanoyl]piperazin-2-yl}acetonitrile	0.884
6	05C	7-(8-methylnaphthalen-1-yl)-4-[(2~{R})-2-methylpiperazin-1-yl]-2-[[(2~{S})-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5~{H}-pyrido[3,4-D]pyrimidine	0.850
7	05F	4-[(1~{R},5~{S})-3,8-diazabicyclo[3.2.1]octan-8-yl]-7-(8-methylnaphthalen-1-yl)-2-[[(2~{S})-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5~{H}-pyrido[3,4-D]pyrimidine	0.829
8	05I	4-[(1~{S},5~{R})-3,8-diazabicyclo[3.2.1]octan-3-yl]-7-(8-methylnaphthalen-1-yl)-2-[[(2~{S})-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5~{H}-pyrido[3,4-D]pyrimidine	0.829
9	K9M	1-{4-[7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4-yl]piperazin-1-yl}propan-1-one	0.789
10	A1B7P	{(2s)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4-yl]-1-[(3r)-3-fluoro-3-(pyridin-2-yl)propanoyl]piperazin-2-yl}acetonitrile	0.776
11	I6T	(3r,4r)-1-[7-(8-chloronaphthalen-1-yl)-2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4-yl]-3-hydroxypiperidine-4-carbaldehyde	0.767
12	K9J	1-{4-[2-{[(2r)-1-(dimethylamino)propan-2-yl]oxy}-7-(3-hydroxynaphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4-yl]piperazin-1-yl}propan-1-one	0.727