Het-PDB Navi2 (PDB: 8KME)

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Ligands
Code	Name		Style	Show	Link
NA	Sodium ion				PoSSuM

Non-standard Residues
Code	Name	Show
0BN	4-carbamimidoyl-L-phenylalanine
CHG	Cyclohexyl-glycine
MLY	N-dimethyl-lysine
TYS	O-sulfo-L-tyrosine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group
NH2	Amino group

Download interaction data: 8KME

Code :

8KME PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN INHIBITED WITH SEL2770.

Release Data :

1999-03-24

Compound :

mol_id	molecule	chains
1	THROMBIN	1
	ec: 3.4.21.5 fragment: LIGHT CHAIN

mol_id	molecule	chains
2	THROMBIN	2
	ec: 3.4.21.5 fragment: HEAVY CHAIN

mol_id	molecule	chains
3	N-ACETYLHIRUDIN	3
	other_details: SYNTHETIC

mol_id	molecule	chains
4	SEL2770	4
	other_details: SYNTHETIC

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific
3
	synthetic: yes

mol_id	organism_scientific
4
	synthetic: yes

Authors :

Mochalkin, I., Tulinsky, A.

Keywords :

THROMBIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, SELECTIDE

Exp. method :

X-RAY DIFFRACTION ( 2.1 Å )

Citation :

Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding.

Mochalkin, I.,Tulinsky, A.
(1999) Acta Crystallogr.,Sect.D 55 : 785 - 793

PubMed: 10089309
DOI: 10.1107/S0907444999000359

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

PDB ID: 8KME

Hetero Atom Contents

Structure summary

Reaction