Brand  (β version)

PDB ID: 7BVF

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Ligands
Code Name Style Show Link
95E Ethambutol PoSSuM
CA Calcium ion PoSSuM
CDL Cardiolipin PoSSuM
DSL Mono-trans, octa-cis decaprenyl-phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 7BVF   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Cryo-EM structure of Mycobacterium tuberculosis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol
Release Data : 2020-04-29
Compound :
mol_id molecule chains
1 Probable arabinosyltransferase B B
ec: 2.4.2.-
mol_id molecule chains
2 Probable arabinosyltransferase A A
ec: 2.4.2.-
mol_id molecule chains synonym
3 Meromycolate extension acyl carrier protein P ACP
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis H37Rv  (taxid:83332) Mycolicibacterium smegmatis MC2 155  (taxid:246196)
gene: embB, Rv3795, MTCY13D12.29
mol_id organism_scientific expression_system
2 Mycobacterium tuberculosis H37Rv  (taxid:83332) Mycolicibacterium smegmatis MC2 155  (taxid:246196)
gene: embA, Rv3794, MTCY13D12.28
mol_id organism_scientific
3 Mycolicibacterium smegmatis MC2 155  (taxid:246196)
Authors : Zhang, L., Zhao, Y., Gao, Y., Wang, Q., Li, J., Besra, G.S., Rao, Z.
Keywords : Mycobacterium tuberculosis, cell wall synthesis, drug target, ethambutol, arabinosyltransferase, EmbA, EmbB, EmbC, acyl carrier protein, arabinogalactan, lipoarabinomannan, drug resistance, TRANSFERASE
Exp. method : ELECTRON MICROSCOPY ( 2.97 Å )
Citation :

Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.

Zhang, L.,Zhao, Y.,Gao, Y.  et al.
(2020)  Science  368 : 1211 - 1219

PubMed: 32327601
DOI: 10.1126/science.aba9102

Reaction

Chain : B
UniProt : P9WNL7 (EMBB_MYCTU)
Reaction : -
Chain : A
UniProt : P9WNL9 (EMBA_MYCTU)
Reaction : -
Chain : P
UniProt : A0R0B3 (ACPM_MYCS2)
Reaction : -