Brand  (β version)

PDB ID: 7JM7

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Ligands
Code Name Style Show Link
0J1 (2r)-3-{[(R)-hydroxy{[(1s,2r,3s,4s,5r,6r)-2,3,4,6-tetrahydroxy-5-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dinonanoate PoSSuM
ATP Adenosine-5'-triphosphate PoSSuM
CL Chloride ion PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 7JM7   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Structure of human CLC-7/OSTM1 complex
Release Data : 2020-09-02
Compound :
mol_id molecule chains synonym
1 Osteopetrosis-associated transmembrane protein 1 B,D Chloride channel 7 beta subunit
mol_id molecule chains synonym
2 H(+)/Cl(-) exchange transporter 7 A,C Chloride channel 7 alpha subunit,Chloride channel protein 7,ClC-7
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: OSTM1, GL, HSPC019, UNQ6098/PRO21201
expression_system_common: Human
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: CLCN7
expression_system_common: Human
Authors : Schrecker, M., Hite, R.
Keywords : Lysosomal, chloride-proton antiporter, chloride transport, ion transport, proton transport, complex, glycosylated, MEMBRANE PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 2.82 Å )
Citation :

Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1.

Schrecker, M.,Korobenko, J.,Hite, R.K.
(2020)  Elife  9

PubMed: 32749217
DOI: 10.7554/eLife.59555

Reaction

Chain : B, D
UniProt : Q86WC4 (OSTM1_HUMAN)
Reaction : -
Chain : A, C
UniProt : P51798 (CLCN7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in) - PubMed:18449189
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