Brand  (β version)

PDB ID: 7BVC

Hetero Atom Contents

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Ligands
Code Name Style Show Link
95E Ethambutol PoSSuM
CA Calcium ion PoSSuM
CDL Cardiolipin PoSSuM
F8L [(2z,6e,10e,14z,18e,22z,26z)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl] [(2s,3s,4s,5r)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl] hydrogen phosphate PoSSuM
PNS 4'-phosphopantetheine PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 7BVC   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol
Release Data : 2020-04-29
Compound :
mol_id molecule chains synonym
1 Integral membrane indolylacetylinositol arabinosyltransferase EmbA A Probable arabinosyltransferase B
ec: 2.4.2.-
mol_id molecule chains
2 Integral membrane indolylacetylinositol arabinosyltransferase EmbB B
ec: 2.4.2.34
mol_id molecule chains synonym
3 Meromycolate extension acyl carrier protein P ACP
Source :
mol_id organism_scientific expression_system
1 Mycolicibacterium smegmatis MC2 155  (taxid:246196) Mycolicibacterium smegmatis MC2 155  (taxid:246196)
gene: embA
mol_id organism_scientific expression_system
2 Mycolicibacterium smegmatis MC2 155  (taxid:246196) Mycolicibacterium smegmatis MC2 155  (taxid:246196)
gene: embB, MSMEI_6221
mol_id organism_scientific
3 Mycolicibacterium smegmatis MC2 155  (taxid:246196)
Authors : Zhang, L., Zhao, Y., Gao, Y., Wang, Q., Li, J., Besra, G.S., Rao, Z.
Keywords : Mycobacterium smegmatis, cell wall synthesis, drug target, ethambutol, arabinosyltransferase, EmbA, EmbB, EmbC, acyl carrier protein, arabinogalactan, lipoarabinomannan, drug resistance, TRANSFERASE
Exp. method : ELECTRON MICROSCOPY ( 2.90 Å )
Citation :

Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.

Zhang, L.,Zhao, Y.,Gao, Y.  et al.
(2020)  Science  368 : 1211 - 1219

PubMed: 32327601
DOI: 10.1126/science.aba9102

Reaction

Chain : A
UniProt : A0R613 (A0R613_MYCS2)
Reaction : -
Chain : B
UniProt : I7GAQ2 (I7GAQ2_MYCS2)
Reaction : -
Chain : P
UniProt : A0R0B3 (ACPM_MYCS2)
Reaction : -