Het-PDB Navi2 (PDB: 6TNF)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
DN	Unknown 2'-deoxynucleotide

Glycosylation
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Download interaction data: 6TNF

Code :

6TNF PDBj RCSB PDB PDBe

Header :

DNA BINDING PROTEIN

Title :

Structure of monoubiquitinated FANCD2 in complex with FANCI and DNA

Release Data :

2020-02-19

Compound :

mol_id	molecule	chains
1	FANCD2	A

mol_id	molecule	chains
2	Fanconi anemia complementation group I	B

mol_id	molecule	chains
3	Polyubiquitin-C	C

mol_id	molecule	chains
4	DNA (33-MER)	D,E
	other_details: An idealized dsDNA of 33 bp of arbitrary sequence was placed and refined into the EM density but the following DNA sequences were used in the sample preparation by annealing oligonucleotides X1, X2, X3, X4, X5, X6: X1: GCGCACCAAGAGATACGCGGTCGAATGCCGAGTAGCCATCAGCG X2: ACCATGCAGCTACTCGGCATTCGACCGCGTATCTGGCGACTACG X3: TATCTCTTGGTGCGC X4: CGCTGATGGCTACTC X5: CGTAGTCGCCAGATA X6: GAGTAGCTGCATGGT

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Gallus gallus (taxid:9031)	Chicken	Spodoptera frugiperda (taxid:7108)
	gene: FANCD2 expression_system_common: Fall armyworm

mol_id	organism_scientific	organism_common	expression_system
2	Gallus gallus (taxid:9031)	Chicken	Spodoptera frugiperda (taxid:7108)
	gene: FANCI expression_system_common: Fall armyworm

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: UBC

mol_id	organism_scientific
4	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Alcon, P., Shakeel, S., Passmore, L.A.

Keywords :

Fanconi anaemia, ubiquitin, DNA repair, DNA damage, inter-strand crosslink, DNA BINDING PROTEIN

Exp. method :

ELECTRON MICROSCOPY ( 3.8 Å )

Citation :

FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.

Alcon, P.,Shakeel, S.,Chen, Z.A. et al.
(2020) Nat.Struct.Mol.Biol. 27 : 240 - 248

PDB ID: 6TNF